Right Atrial Thrombus in a COVID-19 Child Treated Through Cardiac SurgeryCardiovascular Medicine Published on 2020-11-122022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] cardiac Cardiac surgery Child COVID-19 COVID-19 infection COVID-19 virus diagnosis of COVID-19 Fever HRCT inflammatory condition intracardiac mechanism pediatric right RT-PCR SARS-COV-2 infection surgery Thrombus thrombus—echocardiography transthoracic echocardiography treated [DOI] 10.3389/fcvm.2020.579522 PMC 바로가기 [Article Type] Cardiovascular Medicine
Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19✰,✰✰,★,★★Research article Published on 2020-11-012022-10-05 Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids [Category] SARS, 유전자 메커니즘, [키워드] Affect allele arachidonic acid biosynthesis pathway chromosome 11 circulating coding COVID-19 COVID-19 symptom Cytokine storm death Desaturation eicosanoid Europeans expression Fads gene cluster FADS1 fatty Fatty acid functional gene cluster Genetic genetics Haplotype healthy High dose higher risk Highly unsaturated fatty acids implication INDEL induce Inflammation inflammatory condition insertion Major modulation omega-3 pathological response physiological response polymorphism Population predict prothrombotic reduced Regulatory response Rs66698963 SARS-CoV SARS-CoV-2 selective Signaling thrombosis thrombotic tissue unsaturated Variability well [DOI] 10.1016/j.plefa.2020.102183 [Article Type] Research article
Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?고압산소가 COVID-19의 항염증 치료제로 안전하게 사용될 수 있습니까?Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 비임상, [키워드] activate acute respiratory distress acute respiratory distress syndrome Affect Anecdote anti-inflammatory treatment ARDS attenuation breath Can Case report change chemokines Clinical practice compassionate use consequence COVID-19 CT-scan cytokine Cytokines evaluated HBO Hypothesis hypoxia Inflammatory inflammatory cascade inflammatory condition inflammatory conditions Inflammatory response innate immune response innate immune system lung Mild symptom mild symptoms Organ failure oxygen Patient Pneumonitis Prevent Prospective clinical trial pulmonary CT randomized clinical trial reduce reduce mortality respiratory distress safe and reduce SARS-CoV-2 syndrome Tolerance treat Viral [DOI] 10.1016/j.mehy.2020.110224 PMC 바로가기 [Article Type] Article
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory DisordersReview Published on 2020-10-222022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] Activation Brain cause commensal bacteria COVID-19 COVID-19 disease Critical disease Diseases disorders disturbance gut microbiota Gut-brain axis gut-lung axis homeostasis Host host immune system illnesses immune dysfunction immune system Immunity immunomodulation induce Infection Inflammation inflammatory condition Influenza virus influenza virus infection intestine lung maintain Mental mental health modulating multiple sclerosis Neuroinflammation Neurological disorder non-infectious other organ Probiotics PROTECT public health crisis Research respiratory respiratory infection Support tissue damage Treatment viral respiratory infections [DOI] 10.3390/molecules25214891 PMC 바로가기 [Article Type] Review
Outlook of IL-6 signaling blockade for COVID-19 pneumoniaReview Published on 2020-10-052022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] blockade Combination COVID-19 COVID-19 pneumonia Cytokine release syndrome disease Efficacy function Hospitalized hospitalized patient IL-6 IL-6 signaling implication inflammatory condition inhibitor inhibitors interleukin-6 physiological placebo-controlled study pleiotropic Pneumonia Population Randomized real-world data sarilumab Severe COVID-19 pneumonia siltuximab Standard of care therapeutic option Tocilizumab treat Treatment treatment for COVID-19 Trial unmet need [DOI] 10.1186/s41232-020-00134-7 PMC 바로가기 [Article Type] Review
SARS-CoV-2: From Structure to Pathology, Host Immune Response and Therapeutic ManagementReview Published on 2020-09-242022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] advanced age aerosol approach Autoimmune disease bats coronavirus COVID-19 COVID-19 pandemic COVID-19 pathology current diabetes diagnostics different disease Diseases Factors form genetic variability homology Host immune response Human immune response infecting Infection Inflammation Inflammatory inflammatory condition inflammatory process Last molecular mechanism obesity other coronavirus Pathogens physical pro-inflammatory prolonged exposure response Risk factors risk of COVID-19 RNA genome SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection sensitivity sequence homology shown single-stranded Spread Structure syndrome the SARS-CoV-2 the SARS-CoV-2 virus Vaccine development viral respiratory virus [DOI] 10.3390/microorganisms8101468 PMC 바로가기 [Article Type] Review
Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender ImplicationsReview Paper Published on 2020-09-012022-10-31 Journal: Clinical Reviews in Bone and Mineral Metabolism [Category] COVID-19, [키워드] adverse effect available data bone consequence COVID-19 COVID-19 disease COVID-19 patients deficiency Denosumab disease effective effort Fracture risk Gender IL-1 IL-6 immune system implication Infection inflammatory condition Inflammatory cytokines inflammatory disease marker metabolism molecular mechanism Osteoporosis outbreak Patient Prevent risk Safe SARS-CoV SARS-CoV-2 SARS-COV-2 infection stimulate subsequent survival targeting therapeutic strategy therapeutic target TNF-α Vitamin D [DOI] 10.1007/s12018-020-09274-3 PMC 바로가기 [Article Type] Review Paper
Bioactive Lipids as Mediators of the Beneficial Action(s) of Mesenchymal Stem Cells in COVID-19Opinion Published on 2020-07-232022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] acute respiratory disease Anti-inflammatory arachidonic acid ARDS BAL bioactive lipids COVID-19 Cytokine storm Cytokines DGLA disease ENhance GLA IL-6 immune immune check point inhibitory therapy IMPROVE Inflammation inflammatory condition inflammatory disease inhibit inhibitory Lipid management mediator Mesenchymal stem cells MSC MSCs observation PGE2 physiological action precursor pro-inflammatory reported secrete Sepsis STEM stem cell supported Therapeutic approach Therapeutic benefit therapy TNF-α treat virus [DOI] 10.14336/AD.2020.0521 PMC 바로가기 [Article Type] Opinion
IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophilsResearch Published on 2012-05-292022-10-30 Journal: Journal of Neuroinflammation [Category] Coronavirus, [키워드] affecting Autoimmune blockade CD4 CD4+ T cells Central nervous system clinical consequence CNS compared complex coronavirus cytokine Demyelination detrimental disease downstream effector molecule Encephalomyelitis expression Factor feedback loops GM-CSF IFN-γ IFN-γ IL-17 independent Infected inflammatory condition inflammatory disease Interaction mechanism memory mice morbidity Mortality murine Neurotropic coronavirus neutrophil neutrophil infiltration Neutrophils not express pathogenic positive PROTECT provided recipient reduced reducing relative contribution rescued response Result survival T cell T cells Th1 Th17 Th17 cell tissue damage Transcription transcriptional regulation transfer upregulation virus was used wild-type [DOI] 10.1186/1742-2094-9-104 PMC 바로가기 [Article Type] Research