Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA COVID-19 vaccineBNT162b2 mRNA COVID-19 백신에 대한 신속한 반응과 관련된 혈소판 및 면역 신호Article Published on 2022-04-012022-09-12 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), SARS, 진단, [키워드] aggregates B cells Biomarker BNT162b2 BNT162b2 mRNA CD31 circulating platelet COVID-19 COVID-19 vaccine Critical cytokine response dose effective Efficacy elevated enrolled eosinophils expressed feature females first dose healthy volunteer humoral identify immune response immune signature immune system Immunity inhibitory leukocyte median motif mounted mRNA-based COVID-19 vaccine mRNA-based vaccine neutralizing antibody non-classical monocyte of BNT162b2 participant Platelet platelet activation Platelet count rapid immune response rapid response reactive receptor responders second dose stability stimulate the vaccine Vaccine Vaccines Vascular [DOI] 10.1111/jth.15648 PMC 바로가기 [Article Type] Article
An in-silico analysis of ivermectin interaction with potential SARS-CoV-2 targets and host nuclear importin α잠재적인 SARS-CoV-2 표적 및 숙주 핵 임포틴 α와의 이버멕틴 상호작용에 대한 인-실리코 분석Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] accounted Analysis antiparasitic Antiviral agents assist AutoDock AutoDock vina binding binding energy complex complexes COVID-19 deviation docked docking drug target drugs exhibited fluctuation Host in vitro in-silico inhibitory interacting residue Interaction Ivermectin mechanism of action moderate molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics NLS non-structural protein Nsp9 nuclear nuclear localization signal Protein protein-ligand root SARS-CoV-2 SARS-CoV-2 replication surface area target targets trajectory viral infections with COVID-19 [DOI] 10.1080/07391102.2020.1841028 PMC 바로가기 [Article Type] Article
SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications Research Published on 2022-03-312022-10-05 Journal: Scientific Data [Category] 유전자 메커니즘, [키워드] Activation Analysis article Biology condition curated database dataset described disease driving effective experiment groups Inconclusive information inhibitor inhibitory inhibitory compound inhibitory compounds Potential treatment progression Protein provide Research researchers STAT Transcription [DOI] 10.1038/s41597-022-01243-3 [Article Type] Research
Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature’s toolbox of bioactive compoundsReview article Published on 2022-03-142022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, [키워드] approved drug assays binding affinity candidate clinical trials Compound compounds consequence coronavirus Coronaviruses drug effective Enzyme inhibition Extracts in silico in vitro in vivo Infection inhibiting inhibition inhibitor inhibitors inhibitory involved main protease MPro mutations natural compounds Outbreaks pandemic protease protease active site Repurposed drugs Research respiratory SARS-CoV-2 shown vaccination viral life cycle viral replication virus [DOI] 10.1016/j.csbj.2022.03.009 [Article Type] Review article
The vital role of animal, marine, and microbial natural products against COVID-19Covid-19에 대한 동물, 해양 및 미생물 천연 제품의 중요한 역할Review Published on 2022-03-022022-09-10 Journal: Pharmaceutical Biology [Category] 신약개발, 치료제, [키워드] 3CLpro animal Anti-inflammatory Antiviral approach Bromelain carrageenan clinical trial clinical trials Combination combination treatment Context COVID-19 COVID-19 therapy COVID19 database derivative Direct Drug development Effect Efficacy evaluated flavonoids hACE2 highlighting host proteins immunomodulatory properties in silico inhibitory less management mechanism microbial microbial products microorganisms MOST nasal Nasal spray NF-κB objective omega-3 omega-3 supplementation organism outbreak pandemic Pathogenesis peptide peptides pharmacological plants PLPro Prevent profile quercetin raw data researcher Result SARS-CoV-2 SARS-CoV-2coronavirus Science Science Direct searched synergistic synergistic effects tannins target tested therapy these compound these compounds Treatment Viral viral entry Vitamin C Zinc [DOI] 10.1080/13880209.2022.2039215 PMC 바로가기 [Article Type] Review
Inhibition of receptor-binding domain-ACE2 interaction after two doses of Sinovac’s CoronaVac or AstraZeneca/Oxford’s AZD1222 SARS-CoV-2 vaccinesSinovac의 CoronaVac 또는 AstraZeneca/Oxford의 AZD1222 SARS-CoV-2 백신 2회 투여 후 수용체 결합 도메인-ACE2 상호작용 억제Article Published on 2022-03-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome angiotensin-converting enzyme-2 antibodies antibody Antibody Response assays association AZD1222 binding CoronaVac coronavirus COVID-19 decrease domain dose Efficacy elicited enzyme evaluate evaluated facilitate identify incidence individuals inhibit inhibition inhibitory Interaction interquartile range IQR Laboratory median natural infection Population postvaccination prevaccination RBD reactivity receptor Receptor-binding domain robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose serological Sinovac subjects trials Vaccine vaccinees viral neutralization [DOI] 10.1002/jmv.27396 PMC 바로가기 [Article Type] Article
Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach류마티스학에서의 Janus kinase-targeting therapy: 메커니즘 기반 접근Review Published on 2022-03-012022-09-12 Journal: Nature reviews. Rheumatology [Category] MERS, SARS, 진단, [키워드] activate Activation adaptive addition allergic approach atopic dermatitis Autoimmune Autoimmune disease autoreactive T cell B cells cytokine Cytokine storm development Diseases disorders downstream effective glucocorticoid immune Immune-mediated inflammatory diseases Immunity Immunosuppressant implicated Inflammatory bowel disease Inflammatory diseases inhibitory Innate immunity involved Jak JAK inhibitor jak inhibitors JAK-STAT pathway janus Janus kinase multiple cytokine non-specific outcome pathology positive profiles Protein receptors rheumatoid arthritis selective Seven Signal transduction spondyloarthritis STAT suppress systemic lupus erythematosus therapy Transcription transcription factor Treatment [DOI] 10.1038/s41584-021-00726-8 PMC 바로가기 [Article Type] Review
Ligand-based quantitative structural assessments of SARS-CoV-2 3CLpro inhibitors: An analysis in light of structure-based multi-molecular modeling evidencesResearch article Published on 2022-03-012022-10-05 Journal: Journal of Molecular Structure [Category] 신약개발, [키워드] 3CLpro accelerate Analysis ANN applied assessment binding energy binding mode conducted COVID-19 drug candidate Drug discovery effective Evidence functions group HQSAR hydroxy identify inhibitors inhibitory linear molecular molecular docking parameter physicochemical predict QSAR Quantitative Remdesivir Repurposed drug Repurposed drugs required researchers ribavirin SARS-CoV-2 SARS-CoV-2 3CLpro SVM Treatment [DOI] 10.1016/j.molstruc.2021.132041 [Article Type] Research article
Soluble Immune Checkpoints Are Dysregulated in COVID-19 and Heavy Alcohol Users With HIV Infection가용성 면역 체크포인트는 COVID-19 및 HIV 감염이 있는 과음 알코올 사용자의 조절이 잘 안 됩니다.Review Published on 2022-02-232022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] alcohol alcohol consumption alcohol-associated liver disease (ALD) antibacterial immunity antibodies Antiretroviral therapy ART balance binding biological function Biological functions biological significance Biomarker Biomarkers blockade blocking antibodies bloodstream Cancer circulating competition COVID-19 COVID-19 patient COVID-19 patients disease Diseases dysregulated dysregulation Effect Efficacy elevated Evidence exacerbate focus form Health healthy heavy alcohol user HIV HIV infection ICP Imbalance immune Immune cell immune cells immune checkpoint immune defense immune microenvironment immune regulation immune responses in vitro in vivo Infectious diseases Inflammation inhibitory Interaction malignant cell malignant cells membrane membrane-bound mRNA occur Pandemics pathophysiological condition pathophysiological conditions peripheral circulation plasma Plasma levels PLHIV protease public health reducing regulate Regulation Regulatory secretion self-tolerance severity of COVID-19 significantly soluble immune checkpoint stimulatory storm Surveillance Therapies Tumor user with HIV [DOI] 10.3389/fimmu.2022.833310 PMC 바로가기 [Article Type] Review
Discovery of SARS-CoV-2 3CL Pro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand InteractionsArticle Published on 2022-02-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 3CL accumulating acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays binding energy breakthrough infections catalytic dyad cellular conserved coronavirus coronavirus disease covalent inhibitor drug candidate drug design dyad Efficacy effort etiological agent examined exhibited FIVE High-resolution histidine inhibitor inhibitors inhibitory Medicines molecular dynamics simulations molecule design Pro protease residue SARS-CoV-2 significantly structures Vaccine development Viral load viral replications [DOI] 10.3390/ijms23042392 PMC 바로가기 [Article Type] Article