Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3Article Published on 2020-05-312022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Amino acid Analysis antagonistic antiviral response cause Cell component coronavirus correlated Critical degrade dependent on disease downregulated endoribonuclease epidemic diarrhea facilitate Host IFN IFN response IFN signaling pathway IFN-I Infection inhibit innate immune innate response interferon regulatory factor interferon signaling involved IRF3 ISGs Nsp15 other coronaviruses pathogenic mechanism pathway PEDV Protein reduction Replication residue RNA RNA degradation SARS-CoV screened stimulated suppress TBK1 type I interferon virus virus infection [DOI] 10.3390/v12060599 PMC 바로가기 [Article Type] Article
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2Review Article Published on 2020-05-292022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 신약개발, 임상, 치료제, [키워드] “cytokine storm” adaptive adaptive immune system approved biological processe cascade change chemokine Clinical management COVID-19 COVID-19 patients cytokine Cytokine storm Defense develop drugs dysregulation effective drug help highlight Host immune defense immune dysregulation immune response immune signaling pathway immune system immunopathology implicated Infectious diseases Inflammation Inflammatory innate response mechanism Mild molecular pathway pharmacological Prevent reflect SARS-CoV-2 SARS-COV-2 infection Severe case signaling pathway Spread stages standard care Supportive treatments systemic level therapeutic tissue damage treat Treatment triggered urgent investigation Vaccine viral infection virus virus entry widespread [DOI] 10.1038/s41392-020-0191-1 PMC 바로가기 [Article Type] Review Article
Microarray analysis of infectious bronchitis virus infection of chicken primary dendritic cellsResearch Article Published on 2019-07-082022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Actin activate activated Analysis Antigen binding block Cell cellular change DCs dendritic cell dendritic cells disease-causing down-regulated ENhance explain functional Gene Expression Gene ontology Host IBV immune immune function inactivated indicated induce Infection Infectious Bronchitis Virus innate response Interaction leukocyte lncRNA long non-coding RNA Lymphocytes MAPK maturation mechanism Microarray microRNA miRNA miRNAs mRNA mRNAs neutralising non-coding RNA oxidative phosphorylation pathogenic mechanism pathway Pathway analysis performed presenting Protein provide recent regulate Research respond responsible Result significantly suggested supplementary material T cells target gene transcription factor transendothelial migration up-regulated viruses [DOI] 10.1186/s12864-019-5940-6 PMC 바로가기 [Article Type] Research Article
A comparison of interferon gene expression induced by influenza A virus infection of human airway epithelial cells from two different donorsComparative Study Published on 2019-04-152023-06-23 Journal: Virus research [Category] 신종인플루엔자, [키워드] Human airway epithelium Influenza virus innate response Interferons and interferon-stimulated genes. [DOI] 10.1016/j.virusres.2019.02.002 PMC 바로가기 [Article Type] Comparative Study
Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humansClinical Trial Published on 2019-03-282023-06-15 Journal: Vaccine [Category] B형 간염, [키워드] Association with systemic symptoms HBsAg-AS01B adjuvanted vaccine IFNγ signals IL-6 signals innate response Reactogenicity. [DOI] 10.1016/j.vaccine.2019.02.015 PMC 바로가기 [Article Type] Clinical Trial
Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesResearch Article Published on 2016-10-262022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Accessory accessory protein activate Activation acute respiratory syndrome antagonistic Antiviral antiviral host response antiviral host responses antiviral response antiviral signaling binding cause cellular conditions coronavirus coronavirus coronavirus protein curtail Defense described disease dsRNA eIF2α evade expressing expression high mortality rate Host Human IFN-α/β increasingly independent Infection innate response interfere life-threatening Ligand mechanisms MERS-CoV Middle East mild respiratory molecular mechanism motif p4a pathway Pathways phosphorylate PKR platform Prevent Protein protein 4a receptor reported reservoirs respiratory respiratory syndrome coronavirus response SARS-CoV sequestering severe respiratory infection Spread Stress stress granule suppress suppressed therapeutic intervention translation type I interferon viral dsRNA Viral protein virus virus infection viruses [DOI] 10.1371/journal.ppat.1005982 PMC 바로가기 [Article Type] Research Article