Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion
423
[키워드] 40S
5′ UTR
Antisense oligonucleotide
antiviral immunity
block
bypassing
C-terminal domain
circumvent
Concentration
conserved
COVID-19
COVID-19 pandemic
Critical
drug resistance
effective therapy
evade
expressing
Health
highly pathogenic
Host
host protein
human ACE2
infected cell
inhibit
interfere
maintain
mechanism
Messenger RNA
mRNA
mRNA stability
nonstructural protein 1
nucleic acid
pathogenicity
presenting
PROTECT
protein trafficking
Replication
SARS-CoV-2
SARS-CoV-2 pathogenesis
SARS-CoV-2–infected mice
sequence
Significance
suppress
susceptible
targeting
the SARS-CoV-2
therapeutic
therapeutic target
transgenic mice
translation
translational
unique
Vaccines
variants
variants of SARS-CoV-2
Viral protein
viral replication
virulence
virus
[DOI] 10.1073/pnas.2117198119 PMC 바로가기 [Article Type] 423
[DOI] 10.1073/pnas.2117198119 PMC 바로가기 [Article Type] 423