Interference – Page 5 – Communicable Diseases Research

Integrative web-based analysis of omics data for study of drugs against SARS-CoV-2

SARS-CoV-2에 대한 약물 연구를 위한 omics 데이터의 통합 웹 기반 분석

Article

Published on 2021-05-242022-09-01
Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 진단, 치료제,

The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer

암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭

Review

Published on 2021-05-022022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses
[DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review

Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19

TLR 신호 전달에 대한 하이드록시클로로퀸 효과: 노출 부족이지만 COVID-19에서 무시할 수 없음

Review

Published on 2021-03-092022-09-10
Journal: Journal of Immunology Research [Category] SARS, 치료제,

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

코로나바이러스 엔도리보뉴클레아제 nsp15에 의한 항바이러스 스트레스 과립 형성 억제로 효율적인 바이러스 복제 보장

Research Article

Published on 2021-02-262022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, 치료법,

[키워드] accumulation Activation affected aggregation Analysis antagonist antagonists Anti-viral Antiviral array cells conserved coronavirus Coronavirus infection Coronaviruses Critical Crosstalk decrease demonstrated Depletion dsRNA eIF2α ENCODE endoribonuclease Evidence Factors function Heat shock Host host antiviral response host cell host response IBV IBV infection IFN response IFN-β immune response immunofluorescence analysis include increase infected cells Infection Infectious Bronchitis Virus inhibiting inhibition innate immune interfere Interference intrinsic IRF3 knowledge mechanism mRNAs NaCl Nsp15 overcome overexpressed Pattern recognition pattern recognition receptor Pattern recognition receptors PEDV Phosphorylation PKR prevalent Prevent Protein protein synthesis provided PRRs Recognition recruitment reducing Replication reported responsible RNA viruses SARS-CoV SARS-CoV-2 scaffold proteins shown Signaling sodium sodium arsenite Stress stress granule stress response suppression TGEV Transcription translation Trigger triggered turn Viral viral dsRNA virus virus replication viruses wild type
[DOI] 10.1371/journal.ppat.1008690 PMC 바로가기 [Article Type] Research Article

The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection

Pharmacology

Published on 2021-02-232022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

Tipiracil은 우리딘 부위에 결합하여 SARS-CoV-2의 Nsp15 엔도리보뉴클레아제 NendoU를 억제합니다.

Article

Published on 2021-02-092022-09-10
Journal: Communications Biology [Category] MERS, 치료제,

[키워드] active site addition approved assays bind binding pocket binding site biochemical C-terminal catalytic catalytic domain cleave Colorectal cancer complex conserved Coronaviruses crystal structure crystal structures Crystallography drugs endoribonuclease EndoU enzyme Evidence FDA inhibit innate immune response Interaction Interference ions knowledge manganese mechanism mechanisms Molecular biology Nsp15 nucleotide nucleotides recognize responsible RNAs SARS-CoV-2 SARS-CoV-2 Nsp15 sequence specificity structural biology Structure therapeutic intervention tipiracil transition Treatment uracil uridine
[DOI] 10.1038/s42003-021-01735-9 PMC 바로가기 [Article Type] Article

Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach

고 처리량 컴퓨터 스크리닝 및 구조 역학 접근을 통한 SARS-COV2의 NSP15에 대한 약물 설계

Article

Published on 2021-02-052022-09-11
Journal: European journal of pharmacology [Category] SARS, 신약개발, 치료제,

[키워드] (lopinavir (ritonavir) addition approach best binding binding affinity butanamide complement Compound computational analysis contribute COVID-19 Critical dataset dihydrofuran-2(3H)-one drug drug candidate effective endonuclease ethyl explicit Favipiravir feature generate High Throughput Screening host immune system identify Interference lead Lopinavir molecular dynamics molecular dynamics simulations Nsp15 oseltamivir outbreak pandemic pharmacophore potential therapeutic target Protein pyrazine Replication Ritonavir rule SARS-CoV2 screened selected selective small molecule therapeutic training set Treatment unique virulence was selected
[DOI] 10.1016/j.ejphar.2020.173779 PMC 바로가기 [Article Type] Article

Self-reported impact of respirator use on health care worker ability to perform patient care

Article

Published on 2020-12-012023-07-13
Journal: American journal of infection control [Category] SARS,

[키워드] Facial mask Interference Patient interaction Personal protective equipment respirators
[DOI] 10.1016/j.ajic.2020.06.005 PMC 바로가기

Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study

라이노바이러스와 인플루엔자 A 바이러스의 간섭: 임상 데이터 분석 및 실험적 감염 연구

Article

Published on 2020-10-092022-09-10
Journal: The Lancet. Microbe [Category] MERS, 신종인플루엔자, 치료기술,

[키워드] 95% CI Affect airway Analysis Antiviral blocking Cell culture cell cultures Clinical data co-occurrence Course COVID-19 pandemic Culture decrease Department Epidemic Epidemics epithelial Europe European country examination expected expression finding fluorescent Frame funding GFP green fluorescent protein H1N1 H1N1pdm09 host cell IAV idea inclusion criteria indicated Infection Influenza influenza A influenza A virus inhibit inoculated Interference interferon interferon response interferon-stimulated gene interferon-stimulated genes Intervention ISG ISGs medical record Medical Sciences Medicine Microscopy mock infection MOI mRNA mucosa Multiplex PCR multiplicity multiplicity of infection Odds ratio pandemic positive Post-infection primary human airway Protein quantitative PCR Replication reporter respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory virus restored resulting reverse transcription Reverse transcription quantitative PCR rhinovirus RNA Seasonal influenza significantly lower Spread Stimulation subsequent System tested the interferon Time frame USA Viral Viral RNA virus was used
[DOI] 10.1016/s2666-5247(20)30114-2 PMC 바로가기 [Article Type] Article

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

Review

Published on 2020-08-252022-10-04
Journal: EBioMedicine [Category] MERS, SARS, 치료법,

[키워드] addition AKI, acute kidney injury Anticoagulant ARDS, acute respiratory distress syndrome chemokines clinical study COVID-19 COVID-19 patient COVID-19 patients COVID-19, coronavirus disease-2019 endothelial evaluate explained Extracellular functional GAGs, glycosaminoglycans Heparanase heparin Histones HPSE, heparanase HS, heparan sulphate ICU, Intensive care unit Inflammation Inflammatory Inflammatory diseases inhibition Interference IU, international unit kidney leukocyte LMWH LMWH, low molecular weight heparin low molecular weight heparin lung mechanism MERS-CoV, Middle East respiratory syndrome coronavirus molecular weight Mortality NETs, neutrophil extracellular traps pathogenic mechanism Patient report responsible SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus sequence severe inflammation SGP, spike glycoprotein therapeutic dose therapeutic potential Treatment viral cellular entry
[DOI] 10.1016/j.ebiom.2020.102969 PMC 바로가기 [Article Type] Review