Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) CoronavirusReview Published on 2020-10-292022-10-30 Journal: Marine Drugs [Category] COVID-19, MERS, SARS, [키워드] N-acetylgalactosamine-specific lectins N-glycosylation O-glycosylation antiviral activity antiviral agent blocker Cell complex Coronaviruses COVID-19 events glycan glycan probes glycoprotein gp120 griffithsin high-mannose high-mannose glycans HIV-1 Host in vitro Influenza virus lectin mannose-specific lectins probe receptor red algae Replication SARS-CoV-2 seaweed seaweed lectins specificity spike subsequent T/Tn-specific lectins the SARS-CoV-2 Trigger turn viral genome virus [DOI] 10.3390/md18110543 PMC 바로가기 [Article Type] Review
Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human LectinsResearch Article Published on 2020-10-222022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] COVID-19, SARS, [키워드] 3D model affected analysed analyses Analysis characterization characterized complexes epitope evaluated Evidence experiment expressed glycan glycoprotein HEK293F cell Human identify infection process Interaction lectin molecular recognition NMR NMR spectroscopy organ Perspective Receptor binding domain reported responsible SARS-CoV2 SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‑CoV2 spike glycoprotein Structure the RBD tissue [DOI] 10.1002/anie.202011015 PMC 바로가기 [Article Type] Research Article
The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory SystemImmunology Published on 2020-10-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation affecting association cause collectin complement Complement activation complexes concerning contribute COVID-19 disease exacerbate Factor ficolin Infection influence lectin lectin pathway mannose-binding lectin MASP MASP-2 MBL morbidity and mortality Neonatal Pneumonia Prevent respiratory respiratory infection respiratory infections Respiratory system serine protease Side effects System tissue damage Tuberculosis variety [DOI] 10.3389/fimmu.2020.585243 PMC 바로가기 [Article Type] Immunology
Unique immunological profile in patients with COVID-19COVID-19 환자의 독특한 면역 프로필Clinical Trial Published on 2020-10-152022-08-13 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 바이오마커, 임상, 치료제, [키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptive Analysis CD56 CD57 CD69 CD8 Cell contraction Coronavirus-2 COVID-19 COVID-19 patient Cytokines Deceased disease distribution driven by effective expansion expression FcεRIγ Frequency healthy subject healthy subjects help host immunity IL-1β IL-6 IL-8 IL6 immature immune response immune responses Immunoglobulin immunological profile Increased Infection Inflammatory cytokine Inflammatory cytokines interferon Interleukins lectin Lymphocytes monocyte Monocytes Monocytes and macrophages mucin natural killer NK cell NK cells NKG2D outcome overexpressed Patient patients with COVID-19 PD-1 performed Peripheral blood peripheral blood lymphocytes positive cell positive cells programmed cell death programmed cell death protein proportion Protein reduced respiratory restoration SARS-CoV-2 SARS-COV-2 infection secrete secreted secretion Serum level Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severe SARS severe SARS-CoV-2 sialic acid Survivors T cell T cells T-cell TIM-3 Treatment unique viral infection with COVID-19 [DOI] 10.1038/s41423-020-00557-9 PMC 바로가기 [Article Type] Clinical Trial
The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic reviewReview Published on 2020-09-092022-10-04 Journal: Virus research [Category] SARS, 유전자 메커니즘, [키워드] accompanied addition C-lectin pathways candidate gene Case report caused CCR1 CCR9 coronavirus coronavirus endoribonuclease COVID-19 COVID-19 case COVID-19 GWAS COVID-19 pathogenesis Cytokine storm DC-SIGN DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin DC-SIGNDendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin deficiency Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin disease double-strand RNA dsRNA, double-strand RNA dsRNAdouble-strand RNA dysregulated endoU, coronavirus endoribonuclease endoUcoronavirus endoribonuclease Evidence explain expression genetic study Genetic variant genome wide association studies GWAS GWAS, genome wide association studies GWASgenome wide association studies Herpes Simplex Virus 1 herpses simplex encephalitis Host host genetics Host immune defenses HSE, herpses simplex encephalitis HSEherpses simplex encephalitis HSV-1, Herpes Simplex Virus 1 HSV-1Herpes Simplex Virus 1 Human hypothese IL-18 IL-18 binding protein IL-18BP, IL-18 binding protein IL-18BPIL-18 binding protein immune immune response gene immune system implicated inborn errors of immunity Inclusion Inflammasome inflammasome activation Interaction interferon Interleukins International Union of Immunological Societies IUIS, International Union of Immunological Societies IUISInternational Union of Immunological Societies lactate dehydrogenase latency LDH, lactate dehydrogenase LDHlactate dehydrogenase lectin manifestation medical subject heading MeSH, medical subject heading MeSHmedical subject heading Meta-analysis minor allele frequency NLRP1 objective OMIM, Online Mendelian Inheritance in Man (OMIM) OMIMOnline Mendelian Inheritance in Man (OMIM) Online Mendelian Inheritance in Man (OMIM) Pathogenesis pathway Pathways PBMCs, peripheral blood mononuclear cells PBMCsperipheral blood mononuclear cells Peripheral blood mononuclear cells Protein reported Result SARS Coronavirus SARS coronavirus 2 SARS-coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2, SARS Coronavirus 2 SARS-CoV-2SARS Coronavirus 2 SARS-CoV, SARS Coronavirus SARS-CoVSARS Coronavirus severe COVID-19 Study design susceptibility systematic review therapeutic targets TLR pathway TLR pathways treatment for COVID-19 variant viral disease viral infection Viral susceptibility [DOI] 10.1016/j.virusres.2020.198163 PMC 바로가기 [Article Type] Review
An Off-the-Shelf Approach for the Production of Fc Fusion Proteins by Protein Trans -Splicing towards Generating a Lectibody In VitroArticle Published on 2020-06-032022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] antibodies antibody fragment approach binding binding domain binding site demonstrated domain domains Escherichia coli expression Fc functions fused fusion fusions Genetic HIV IgG Immunoglobulin G in vitro Infectious disease inhibit lectibody lectin N-terminus Organisms potential therapeutic agent produced producing Production Protein protein trans-splicing protein ligation SARS Coronavirus scytovirin segmental isotopic labeling split intein therapeutic Tran virus entry [DOI] 10.3390/ijms21114011 PMC 바로가기 [Article Type] Article
Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by LectinsArticle Published on 2020-05-132023-06-14 Journal: Cell Host & Microbe [Category] Fulltext, 신종인플루엔자, [키워드] antigenicity glycoprotemics glycosylation hemagglutinin Influenza virus lectin N-glycan neutralization oligomannose universal labeling. [DOI] 10.1016/j.chom.2020.03.009 PMC 바로가기
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivoArticle Published on 2020-01-282023-06-14 Journal: Proceedings of the National Academy of Sciences of [Category] Fulltext, 신종인플루엔자, [키워드] Antiviral hemagglutinin Influenza virus lectin membrane fusion [DOI] 10.1073/pnas.1915152117 PMC 바로가기
The genetic architecture of helminth-specific immune responses in a wild population of Soay sheep ( Ovis aries )Soay 양의 야생 개체군에서 기생충 특이적 면역 반응의 유전적 구조( Ovis aries )Research Article Published on 2019-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Adults Affect antibody antibody level antibody levels blood plasma chromosome CIITA class CLEC16A collected complex condition conditions Containing contribute driver Drivers ecological Effect Evidence evidence of Genetic genetic architecture genetic control Genetic variation genomic region heritable variation histocompatibility Host hosts humans identify IgA IgA level IgA levels IgE IgG IgG antibodies IgG antibody IgG level IgG levels IGH immune Immune profile immune response immune responses Immunity Immunoglobulin immunological Infection influence investigated knowledge Laboratory lectin loci maintain Major major histocompatibility complex MHC natural populations natural selection nematodes offer Organisms Ovis parasite parasites Population prevalent provide response sheep significantly the major histocompatibility traits understanding Variation while [DOI] 10.1371/journal.pgen.1008461 PMC 바로가기 [Article Type] Research Article
Antigen Sampling CSF1R -Expressing Epithelial Cells Are the Functional Equivalents of Mammalian M Cells in the Avian Follicle-Associated Epithelium항원 샘플링 CSF1R 발현 상피세포는 조류 여포 관련 상피에서 포유류 M 세포의 기능적 동등체이다.Original Research Published on 2019-10-222024-07-29 Journal: Frontiers in immunology [Category] 살모넬라증, [키워드] antigen uptake Avian CSF1R lectin M cell mucosa-associated lymphoid tissue Salmonella transgenic reporter chicken [DOI] 10.3389/fimmu.2019.02495 PMC 바로가기 [Article Type] Original Research