Role of Nutraceuticals in COVID-19 Mediated Liver DysfunctionCOVID-19 매개 간 기능 장애에서 기능 식품의 역할Review Published on 2020-12-132022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] ACE2 an area Antiviral antiviral therapy benefit co-morbidities co-morbidity coronavirus COVID-19 epidemiological studies Health health benefits hepatic dysfunctions hepatoprotective agents hepatotoxicity immunomodulatory increased risk information Injury juncture liver dysfunction management Mediated mitigate morbidities nutraceutical nutraceuticals Pandemics planet provide reported Research role SARS-CoV-2 Spread therapy virus with COVID-19 [DOI] 10.3390/molecules25245905 PMC 바로가기 [Article Type] Review
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다Review Published on 2020-12-062022-09-12 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 진단, [키워드] α2-AP, α2-antiplasmin ACE2 ACE2, angiotensin-converting enzyme 2 activate addition Affect causative agent cause caused cell tropism circulating clinical observations Concentration contribute coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 infection COVID-19 pandemic death determine effective Exclusive or explain expression Factor HAI-1/SPINT1 heart host cells Infection infection rate information inhibitor inhibitors kidney kidney damage kidneys liver liver dysfunction Lungs MASPs, membrane-associated serine proteinases membrane fusion membrane-associated serine proteinases (MASPs) membrane-bound MERS, Middle East respiratory syndrome much higher myocardial injury Neurological complications organ other organ other organs PAI-1, plasminogen activator inhibitor 1 PCI, protein C inhibitor positive predominant proteinase QM/MD, quantum mechanical/molecular dynamics receptor relative SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS, Severe acute respiratory syndrome Sepsis Serine serine proteinase serpins significantly higher similarity spike (S) protein Spike protein SPINT1 SPINT2 structure–function relationship synergy term the disease the patient the SARS-CoV-2 thrombotic TMPRSS2 transmembrane transmission rate Treatment uPA, urokinase-type plasminogen activator Vaccine viral fusion viral spike protein viral spike proteins [DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France장기간 ACE 억제제/ARB 사용은 중증 COVID-19 환자의 중증 신장 기능 장애 및 급성 신장 손상과 관련이 있습니다: 프랑스 북동부의 추천 센터 코호트 결과Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] 95% CI 95% confidence interval ACE ACEi ACEi/ARB acute kidney Acute kidney injury Acute respiratory failure Analysis angiotensin angiotensin receptor blocker Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB association biochemical Biomarker center characteristic consecutive patient consecutive patients converting enzyme inhibitor coronavirus disease Coronavirus disease 2019 COVID-19 creatinine daily dose diagnosed disease Enzyme inhibitor evaluated France heart increase in increased risk independent predictors inflammatory reaction influence kidney Lisinopril liver dysfunction liver dysfunctions Logistic regression analysis longitudinal cohort study lung marker multivariable nitrogen Occurrence Odds ratio outcomes Patient patients performed phosphorus predict predictor receiver operating characteristic receptor receptor blocker Referral repeated measures Respiratory failure Result retrospective risk SARS-CoV-2 severe coronavirus disease severe COVID-19 severity treated urea urea nitrogen were assessed [DOI] 10.1093/cid/ciaa677 PMC 바로가기 [Article Type] Article
A meta-analysis of the impact of COVID-19 on liver dysfunctionResearch Published on 2020-11-042022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, SARS, [키워드] 95% CI acute respiratory symptoms acute respiratory syndrome addition Analysis association AST calculate caused Clinical severity Combination connection coronavirus COVID-19 COVID-19 patient COVID-19 patients elevated heterogeneity liver liver dysfunction Liver injury management Meta-analysis Mortality non-survivor novel coronavirus disease Patient patients with COVID-19 performed Pneumonia Result review SARS-CoV-2 sensitivity analysis serum severe COVID-19 patient severity of COVID-19 shown significant difference significantly survivor was used Web of Science worldwide pandemic [DOI] 10.1186/s40001-020-00454-x PMC 바로가기 [Article Type] Research
Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patientsArticle Published on 2020-11-012023-07-11 Journal: Diabetes & metabolic syndrome [Category] SARS, [키워드] clinical profile COVID-19 liver dysfunction SARS-CoV-2 [DOI] 10.1016/j.dsx.2020.10.001 PMC 바로가기
Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases혈청 알부민 수치 감소는 COVID-19 환자의 나쁜 예후를 나타냅니다: 2,623명의 입원 사례에서 간 손상 분석Article Published on 2020-11-012022-09-11 Journal: Science China. Life sciences [Category] SARS, 유전자 메커니즘, [키워드] activated Admission adult COVID-19 patient albumin Analysis aPTT cause caused Chinese cholesterol clinical Clinical outcome clinically Coagulopathy Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death death group Decreased diagnosed disease-associated elevated enrolled Exacerbation global pandemic groups guideline HDL HDL-C hepatic injury hepatic injury. hepatotoxicity high-density High-density lipoproteins hospital Hospitalization Hospitalized Hypoalbuminemia hypoproteinemia indicate Inflammatory cytokine Inflammatory cytokines inflammatory factors Inflammatory response Inflammatory responses interquartile range investigated IQR LDL LDL-C leads lipoprotein liver dysfunction low-density Low-density lipoprotein low-density lipoproteins median age occurred on admission partial thromboplastin time Patient poor prognosis progression reflected Retrospective study serum serum albumin significantly lower survivor the disease the patient three groups THROMBOPLASTIN Tongji Hospital were measured Wuhan, China [DOI] 10.1007/s11427-020-1733-4 PMC 바로가기 [Article Type] Article
COVID-19 and the liver: What do we know after six months of the pandemic?Discussion Published on 2020-11-012022-10-05 Journal: Annals of hepatology [Category] SARS, 유전자 메커니즘, [키워드] abnormality acute respiratory syndrome Affect Comorbidity coronavirus COVID-19 COVID-19 comorbidities COVID-19 symptoms Critical described Follow-up Hospitalization host genetics Improved liver Liver damage Liver disease liver dysfunction Liver injury pandemic virus Patient SARS SARS-CoV-2 viral disease virus infection [DOI] 10.1016/j.aohep.2020.09.001 [Article Type] Discussion
Extrapulmonary manifestations of COVID-19: Radiologic and clinical overviewReview Published on 2020-10-012023-07-06 Journal: Clinical imaging [Category] SARS, [키워드] COVID-19 Extrapulmonary manifestation gastrointestinal complications liver dysfunction Lymphadenopathy neurological manifestations pericardial effusion renal dysfunction SARS-CoV-2 [DOI] 10.1016/j.clinimag.2020.05.013 PMC 바로가기 [Article Type] Review
Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective StudyMedicine Published on 2020-09-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus 28-day mortality Acute cardiac injury Acute kidney injury Acute liver injury ARDS Blood urea nitrogen cardiac chest CT scan clinical Clinical characteristics Confirmed COVID-19 infection consolidation COVID-19 COVID-19 infection Critical Critically ill develop diastolic died disease dysfunction early stage echocardiography ECMO enrolled extracorporeal membrane oxygenation GGO Ground glass opacity hospital Hospitalization increased cardiac output Infection Invasive mechanical ventilation less liver dysfunction lung involvement Manifestations men Mortality Most patient non-invasive ventilation novel Older organ dysfunction outcome Patient Platelet positive Prone position renal replacement therapy retrospective cohort study RT-PCR Severe case severe patients severity suffered treated Ventilation [DOI] 10.3389/fmed.2020.552002 PMC 바로가기 [Article Type] Medicine
Hepatic consequences of COVID-19 infection. Lapping or biting?Review article Published on 2020-07-012022-10-05 Journal: European journal of internal medicine [Category] SARS, 치료제, [키워드] activities Affect antiviral drugs appear Aspartate aminotransferase Asymptomatic China complex condition consequence coronavirus disease COVID-19 COVID-19 infection COVID-19 infections develop distress dysfunction elevated greater hepatic Hospital stay hypoxia impair include Infection information Ischemia-reperfusion damage liver Liver damage liver diseases liver dysfunction Liver injury manifestation mechanism men Mild multiple organ dysfunction Nonalcoholic Fatty Liver Disease Older outbreak Patient patients Prevalence problems Prognosis required SARS-CoV-2 Sepsis serum systemic inflammatory response therapeutic option Toll-like receptors women [DOI] 10.1016/j.ejim.2020.05.035 [Article Type] Review article