Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19Aspartate transferase-to-platelet ratio index-plus: COVID-19 환자의 사망 위험을 예측하기 위한 새로운 단순화 모델Multicenter Study Published on 2022-04-282022-09-11 Journal: World journal of gastroenterology [Category] 바이오마커, [키워드] Admission age all consecutive adult patients All-cause in-hospital mortality an area analyses analyzed aspartate Aspartate transferase Aspartate transferase-to-platelet ratio index association Biomarker category clinically conducted confounders coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality COVID-19 patients develop died ferritin Hospital mortality Hospital stay In-hospital in-hospital mortality include inclusion criteria independent independent of intensive care intensive care unit liver Liver injury Logistic regression Logistic regression analyses lung male median age medical record medical records Mortality multicenter cohort study on admission Patient patient cohort patients with COVID-19 performance Platelet Platelets Predictive predictor predictors presenting regression analysis retrieved retrospective risk SARS-CoV-2 Serum ferritin significantly Spectrum syndrome university [DOI] 10.3748/wjg.v28.i16.1671 PMC 바로가기 [Article Type] Multicenter Study
Liver Injury in COVID-19 Patients with Drugs as Causatives: A Systematic Review of 996 DILI Cases Published 2020/2021 Based on RUCAM as Causality Assessment Method약물을 원인으로 하는 COVID-19 환자의 간 손상: 인과 평가 방법으로 RUCAM을 기반으로 2020/2021 게시된 996개의 DILI 사례에 대한 체계적인 검토Review Published on 2022-04-272022-09-11 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] Abnormalities abnormality Alanine alanine aminotransferase Algorithm ALT ALT/AST antiviral drug antiviral drugs aspartate Aspartate aminotransferase assessment AST Causality caused Characteristics China Clinical characteristics clinical feature Clinical features confounders confounding variable coronavirus disease country COVID-19 COVID-19 case COVID-19 patient COVID-19 patients defined Diagnosis diagnostic DILI drug drug treatment Drug-induced liver injury drug-induced liver injury. Established diagnosis feature female hepatocellular injury India Japan Liver disease liver diseases Liver injury liver test Liver tests male median age Montenegro Most patients outcome patients patients treated provided ranged reported review robust Roussel Uclaf Causality Assessment Method RUCAM searched Spain systematic review the mean therapeutic efficacy Treatment Undetermined virus [DOI] 10.3390/ijms23094828 PMC 바로가기 [Article Type] Review
Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant [DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article
Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach공동 모델링 접근법을 사용하는 COVID-19 입원 환자의 염증 바이오마커와 간 손상의 종단 관계Article Published on 2022-04-012022-09-11 Journal: Scientific Reports [Category] 바이오마커, 치료법, 치료제, [키워드] age Alanine Alanine transaminase alkaline phosphatase ALT approach aspartate Aspartate transaminase AST Biomarker blood lymphocyte count C-reactive protein change consecutive patient correlated correlation COVID-19 COVID-19 infection CRP D-dimer decrease died evaluate Generalized hospital Hospitalization hospitalized patient Inflammation inflammation marker inflammation markers interleukin interleukin-6 joint Liver damage Liver disease Liver injury longitudinal lymphocyte Lymphocyte count marker mechanism negative correlation Patient patients with COVID-19 phosphatase plasma positive serum serum C-reactive protein Sex Spain statistical survival Survivors systemic inflammation the patient therapy was used were used [DOI] 10.1038/s41598-022-09290-x PMC 바로가기 [Article Type] Article
Post-COVID-19 Unusual Inflammatory Syndromes Detected on 18F-FDG PET/CT Scan18F-FDG PET/CT 스캔에서 코로나19 이후 비정상적인 염증 증후군 발견Case Reports Published on 2022-04-012022-09-11 Journal: Clinical nuclear medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute coronary syndromes COVID-19 pandemic disorders FDG Features gastrointestinal symptoms Inflammatory kidney Liver injury manifestation Musculoskeletal Myocardial dysfunction myositis neurological panniculitis PET/CT respiratory symptoms SARS-CoV-2 thromboembolic [DOI] 10.1097/RLU.0000000000004088 PMC 바로가기 [Article Type] Case Reports
Management of hepatitis B virus reactivation due to treatment of COVID-19코로나19 치료로 인한 B형 간염 바이러스 재활성화 관리Review Published on 2022-04-012022-09-11 Journal: Hepatology international [Category] B형 간염, 치료제, [키워드] Antiviral Baricitinib Corticosteroids COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients current dysregulated Evidence Future HBV HBV infection Hepatitis hepatitis B Hepatitis B virus High-dose Immunosuppression immunosuppressive immunosuppressive therapies immunosuppressive therapy increased risk Infection Inflammatory response inhibitor inhibitors janus Janus kinase Liver function test Liver injury management monoclonal antibody other diseases pandemic Patient potentially life-threatening Prophylaxis Reactivation receiving risk sarilumab SARS-CoV-2 severe disease the patient Therapies Tocilizumab Tofacitinib Treatment treatments for COVID-19 treatments of COVID-19 [DOI] 10.1007/s12072-022-10306-x PMC 바로가기 [Article Type] Review
Integrated hepatic single-cell RNA sequencing and untargeted metabolomics reveals the immune and metabolic modulation of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumonia통합 된 간 단일 세포 RNA 시퀀싱 및 표적화되지 않은 대사체는 코로나 바이러스-유도 폐렴과 마우스에서 Qing-Fei-Pai-Du 달인의 면역 및 대사 조절을 보여준다.Article Published on 2022-03-012022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 유전자 메커니즘, 치료제, [키워드] alteration Analysis attenuate B cells BALB/c mice best CD4 CD8 clinically Cold Cold-damp environment Combination Control control group coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 patients Cytokines damp environment disease disease-associated exposure to Gene Expression HCoV HCoV-229E human coronavirus IFN-γ IL-6 immune immune function Immunity immunological IMPROVE indicated infecting Infection Inflammation Inflammatory cytokine Inflammatory cytokines knowledge Liver injury liver tissue Lymphocytes mechanism mechanism of action metabolic function metabolism metabolomics mice Model modulate modulation mouse model Mouse models performed Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia profile purine Qing-Fei-Pai-Du decoction reduce regulated Regulatory reveal RNA RNA sequencing significantly significantly increased Single-cell RNA sequencing status T cells TCM therapy TNF-α transcriptional treat treated Treatment Untargeted metabolomics [DOI] 10.1016/j.phymed.2021.153922 PMC 바로가기 [Article Type] Article
Molecular consequences of SARS-CoV-2 liver tropismSARS-CoV-2 간 친화성의 분자적 결과Article Published on 2022-03-012022-09-11 Journal: Nature metabolism [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Analysis Autopsy Clinical outcome clinical outcomes cohorts of patient consequence coronavirus COVID-19 Evidence Extrapulmonary Frequency heart histopathological Hospitalization human liver identify increase independent indicated Isolation kidney liver liver function tests Liver injury liver tissue manifestation molecular organ-specific organs patient cohort pharmacological potential long-term sequelae profile proteomic respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 similarities similarity specimens targets Transcription transcription factor tropism tropism of SARS-CoV-2 Viral viral infection viral infections Viral RNA viral RNA detection with COVID-19 [DOI] 10.1038/s42255-022-00552-6 PMC 바로가기 [Article Type] Article
Moxibustion for anorexia in COVID-19 A protocol for systematic review and meta-analysisCOVID-19에서 식욕 부진에 대한 moxibustion 체계적인 검토 및 메타 분석을위한 프로토콜3800 Published on 2022-02-252022-08-31 Journal: Medicine [Category] COVID-19, COVID19(2023년), MERS, meta-analysis, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anorexia assessment tool carried caused China Chinese Cochrane Library controlled trials corona virus disease 2019 coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 digestive Efficacy and safety evaluate evaluated Evidence exclusion criteria Health Organization Inclusion inclusion and exclusion criteria Infrastructure international public health journal language Liver injury Markov chain Markov chain Monte Carlo method Meta-analysis Monte Carlo method moxibustion network Network meta-analysis outbreak patients with COVID-19 performed protocol Randomized controlled trial Randomized controlled trials registration number reported respiratory respiratory symptoms risk SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus Spread Stata Symptom systematic review the disease therapy Traditional Chinese medicine treat Treatment Trial Registration Number typical respiratory symptom typical respiratory symptoms used to evaluate World Health Organization [DOI] 10.1097/MD.0000000000028894 PMC 바로가기 [Article Type] 3800
Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patientsObservational Study Published on 2022-02-072022-10-04 Journal: World journal of gastroenterology [Category] 임상, [키워드] abnormality acute respiratory syndrome adjusted Admission alanine aminotransferase albumin level alkaline phosphatase ALP ALT Asian Aspartate aminotransferase association AST Baltimore Bilirubin bilirubin. can be used Clinical characteristics Clinical outcome collected coronavirus COVID-19 COVID-19 patient COVID-19 severity Cox regression Cox regression analysis demographic disease severity drugs elevated Factor highest Hospital admission Hospitalization Hospitalized hospitalized patient in-hospital mortality Johns Hopkin Laboratory liver Liver injury Liver tests Measures mechanical ventilation mortality risk obesity Older age Other outcome Patient patients patients with COVID-19 predict Prevalence prevalent Prognosis retrospective risk serum severe acute respiratory syndrome coronavirus 2 severity severity and prognosis severity of COVID-19 System the patient therapy total bilirubin Treatment United States variable was used with COVID-19 [DOI] 10.3748/wjg.v28.i5.570 PMC 바로가기 [Article Type] Observational Study