A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood코로나19에 감염된 말초혈액에서 차등적인 circRNA와 lncRNA 발현에 관한 연구Article Published on 2021-04-122022-09-10 Journal: Scientific Reports [Category] MERS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] activities Apoptosis Biomarkers carried cell cycle Clinical genetics conducted COVID-19 COVID-19 infection COVID-19 patient COVID-19 virus database diagnostic differentially expressed Diseases enrichment analysis Exosome Exosomes expression Gene Expression genetic interaction healthy host cell immune immune tolerance infection mechanism Inflammation information involved KEGG life lncRNA mRNA outbreak pathway Peripheral blood Perspective recurrence Regulation reported sequenced Sequencing signaling pathway therapeutic Transmission Treatment [DOI] 10.1038/s41598-021-86134-0 PMC 바로가기 [Article Type] Article
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signalinglncRNA Snhg1-Vps13D 소포 트래피킹 시스템은 IL-7 신호 전달의 이중 효과 조절을 통해 메모리 CD8 T 세포 확립을 촉진합니다Article Published on 2021-03-242022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 진단, [키워드] acute viral infection Adaptive immunity Blimp1 CD8 CD8 T cell CD8 T cells Cell Cell Biology conserved convalescent COVID-19 patients differentiation Effect expression expression pattern Human IL-7 IL7R indicated Infection lncRNA mechanism membrane memory memory formation mice Non-coding RNAs pandemic pathogen pathogen-specific PBMC performed persistence promote Protein recent regulated Reinfection RNA Signaling Snhg1 STAT3 subset survival T cell T cells TCF7 transcriptional vaccination Vesicle viral infection Vps13D [DOI] 10.1038/s41392-021-00492-9 PMC 바로가기 [Article Type] Article
Risk stratification by long non‐coding RNAs profiling in COVID‐19 patientsCOVID-19 환자의 긴 비코딩 RNA 프로파일링에 의한 위험 계층화Original Article Published on 2021-03-232022-09-10 Journal: Journal of Cellular and Molecular Medicine [Category] 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm Analysis caused coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 disease enrolled Frame function functions global pandemic Health healthy control healthy controls heterogeneous immune individuals information lack lncRNA Long mononuclear cell mononuclear cells nucleotide nucleotides Open reading frame operator Patient Peripheral blood Peripheral blood mononuclear cells pulmonary injury reported respiratory risk RNA RNA sequencing RNA‐seq SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus Stratification subclass subtype Transcriptome valuable resource [DOI] 10.1111/jcmm.16444 PMC 바로가기 [Article Type] Original Article
mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 InfectionmRNA-lncRNA 공동 발현 네트워크 분석, 심각한 SARS-CoV-2 감염 시 면역 기능 장애에서 lncRNA의 역할 밝혀Article Published on 2021-03-032022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] Activation addition affected analyzed anti-viral response anti-viral responses BALF Bronchoalveolar lavage fluid Clinical features co-expression network co-expression network analysis correlated COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients critical COVID-19 patients cytokine cytokine signaling Cytokine storm Cytokine storms Cytokines differentially expressed epithelial cell epithelial cell line expression Factor global public health Host human lung human lung epithelial cell lines hyper-inflammatory response Hyper-inflammatory responses immune response immune responses Infection involved lncRNA long non-coding RNA Lungs molecular interaction molecular mechanism network neutrophilia non-coding RNA pathway Patient patients plasma pro-inflammatory cytokine pro-inflammatory cytokines required respiratory respiratory disorder responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 virus Sepsis Sequencing severe SARS severe SARS-CoV-2 specimen the cytokine storm Transcriptome transcriptome sequencing with COVID-19 [DOI] 10.3390/v13030402 PMC 바로가기 [Article Type] Article
A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorderReview Published on 2021-03-012023-07-13 Journal: Life sciences [Category] SARS, [키워드] CFTR co-morbidities lncRNA miRNA mucins Nano-formulations [DOI] 10.1016/j.lfs.2020.118959 [Article Type] Review
MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2Article Published on 2021-02-182022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] affected bind binding candidate COVID-19 Diseases distribution drug effective Gene Expression H19 human miRNAs in viral Infection inflammatory complications inhibiting leader sequence lncRNA Long long non-coding RNA microRNA motif non-coding RNA Non-coding RNAs nucleotide oligosequences Potential promote promoted pulmonary arterial hypertension Respiratory system RNA SARS-CoV-2 SARS-CoV-2 genome selective sequence Specific spike target target therapy the SARS-CoV-2 genome therapy transcript Vaccine viral genome viral infections Viral RNA viral-induced [DOI] 10.3390/ncrna7010014 PMC 바로가기 [Article Type] Article
Identification and analysis of long non-coding RNAs and mRNAs in chicken macrophages infected with avian infectious bronchitis coronavirusResearch Article Published on 2021-01-202022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] addition Affect amino acid metabolism Analysis bronchitis cells cellular chicken competing coronavirus cultured cell differentially expressed down-regulated expression profile Factor Gga-miR-30d HD11 Host IBV IBV infection identification indicated Infectious Bronchitis Virus Innate immunity involved lncRNA Long long non-coding RNA Macrophage miR-146a-5p mRNA mRNAs non-coding RNA nucleic acid metabolism nucleotides Ontology Pathogenesis pathway enrichment provided Result RNA Sequencing subset supplementary material uninfected cells up-regulated viral infections [DOI] 10.1186/s12864-020-07359-3 PMC 바로가기 [Article Type] Research Article
Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19Bioengineering and Biotechnology Published on 2021-01-152022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] activated acute respiratory distress Alpha Alter Analysis ARDS Betacoronavirus candidate caused cellular processes conserved COVID-19 COVID-19 cytokine storm cytokine Cytokine storm Cytokines disease DNA damage FIVE functions Gene Expression Genes Genetic humans identify in vitro in vivo infect inflammatory immune response lncRNA Long marker markers MERS-CoV new strain non-coding RNA NorAD outbreak overexpressed Regulation regulatory element RNA SARS-CoV SARS-CoV-2 storm syndrome targets the disease virus Wuhan, China [DOI] 10.3389/fbioe.2020.582953 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infectionResearch Article Published on 2020-10-272022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] Alter Analysis analyzed Cell cellular COVID-19 deregulated determine differentially expressed Differentially expressed genes disease expressed Gene Expression host response identify immune response in viral infections involved lncRNA long noncoding RNA lung epithelial cell material miRNA outcome proliferation protein-coding genes Regulation RNA-seq dataset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins survival viral infection viral pathogenesis viral proliferation [DOI] 10.2217/fvl-2020-0188 PMC 바로가기 [Article Type] Research Article