log-rank test – Page 5 – Communicable Diseases Research

Bilirubin Levels as Potential Indicators of Disease Severity in Coronavirus Disease Patients: A Retrospective Cohort Study

Medicine

Published on 2020-11-092022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study

Research article

Published on 2020-11-052022-10-05
Journal: EClinicalMedicine [Category] 바이오마커, 치료법,

[키워드] acute respiratory distress syndrome acute respiratory illness approach arterial oxygen tension Bacteremia benefit Biomarker Biomarkers Blood urea nitrogen C5 inhibitor caused changes in clinical laboratory complement Complement pathway conjugated bilirubin coronavirus COVID-19 Cytokines decrease eculizumab Efficacy and safety finding fraction funding Hemolysis hemorrhage hypoxia IMPROVE Inflammation inhibitor intensive care Laboratory Lactate log-rank test nonrandomized oxygen pathway Patient patients treated Platelet Pneumonia Primary outcome Prothrombin time rapid increase reduce reduced SARS-COV-2 infection Sepsis Serious Adverse Event severe COVID-19 significantly more standard care survival treated Treatment Ventilator-associated pneumonia viral infection
[DOI] 10.1016/j.eclinm.2020.100590 [Article Type] Research article

Remdesivir for the Treatment of Covid-19 — Final Report

Original Article

Published on 2020-10-082022-11-01
Journal: The New England Journal of Medicine [Category] COVID-19, MERS, SARS,

[키워드] 95% CI 95% confidence interval adverse event Analysis antiviral agent assigned Clinical improvement conducted coronavirus disease defined discharge disease severity double-blind estimate evaluated Evidence hazard ratio hospital Hospitalization Hospitalized Infection Infectious disease Intravenous remdesivir Kaplan–Meier Loading dose log-rank test Lower respiratory tract Median recovery time Mortality Odds ratio Patient Placebo placebo-controlled trial Primary outcome randomization Randomized Randomly receive Remdesivir report reported Result shown the patient therapeutic agent Time to recovery Treatment
[DOI] 10.1056/NEJMoa2007764 PMC 바로가기 [Article Type] Original Article

Survival and predictors of deaths of patients hospitalised due to COVID-19 from a retrospective and multicentre cohort study in Brazil

Original Paper

Published on 2020-09-072022-11-01
Journal: Epidemiology and Infection [Category] COVID-19, SARS,

[키워드] age Asthma asthmatic Better Brazil calculated clinical factor cohort study Coronavirus infections COVID-19 death diabete diabetes disease distress Dyspnoea function hazard ratio hospital hospitalisation hospitalisations hospitalised HRs ICU increased risk intensive care invasive Kaplan–Meier Kidney disease log-rank test multicentre Multiple regression Neurological disease outbreak Patient pneumopathy predictor Prognosis Prognostic factors retrospective Risk factors SARS virus socio-demographic survival survival analysis survival curve survival function syndrome ventilatory support was used X-ray
[DOI] 10.1017/S0950268820002034 PMC 바로가기 [Article Type] Original Paper

Role of Biochemical Markers in Invasive Ventilation of Coronavirus Disease 2019 Patients: Multinomial Regression and Survival Analysis

Internal Medicine

Published on 2020-08-262022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] 95% confidence interval acute respiratory distress acute respiratory syndrome Admission Affect age airway Analysis applied biochemical marker C-reactive protein (CRP carried conducted contributing to coronavirus coronavirus disease COVID-19 COVID-19 patients creatinine CRP D-dimer death discharge disease distributions elevated female group hemoglobin hospitalized COVID-19 patients hypernatremia ICU Infectious diseases intensive care invasive invasive ventilation Kaplan-Meier survival curve Laboratory laboratory investigation lactate dehydrogenase LDH leucocyte Leukocytosis log-rank test Lungs Lymphocytes lymphocytopenia males marker material Mortality multinomial logistic regression multinomial regression Neutrophils Non-invasive non-invasive ventilation non-survivor observation Odds ratio Pakistan pandemic pathogen Patient patients PCT positive positive airway pressure predict presenting Pulmonology raised Regression Respiratory failure Respiratory Support Respiratory system responsible Result risk stratification role SARS-CoV-2 serum Serum ferritin serum sodium significantly sodium statistically subject Supplemental oxygen therapy survival survivor syndrome the patient urea Ventilated Ventilation ventilator was performed
[DOI] 10.7759/cureus.10054 PMC 바로가기 [Article Type] Internal Medicine

Prognostic value of lactate dehydrogenase for in-hospital mortality in severe and critically ill patients with COVID-19

Research Paper

Published on 2020-08-192022-10-29
Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS,

[키워드] Accuracy analyzed association Biomarkers coronavirus disease COVID-19 COVID-19 severity Cox regression Cox regression model Critically ill patient cutoff value dead death determine Disease progression enrolled evaluate hazard high accuracy high risk In-hospital death in-hospital mortality independent risk factor Kaplan-Meier method lactate dehydrogenase LDH log-rank test multiple organ dysfunction multivariate outcome Patient patients physician predicted Predictive Prevent prognostic prognostic biomarker Prognostic factor Prognostic value remained resource Retrospective study sensitivity severity significantly higher single-center specificity survival curve survival group Treatment were used with COVID-19
[DOI] 10.7150/ijms.47604 PMC 바로가기 [Article Type] Research Paper

Effectiveness of Interferon Beta 1a, compared to Interferon Beta 1b and the usual therapeutic regimen to treat adults with moderate to severe COVID-19: structured summary of a study protocol for a randomized controlled trial

Letter

Published on 2020-06-032022-10-29
Journal: Trials [Category] Coronavirus, SARS,

[키워드] 95% confidence interval Adjusted analysis Administered Admission age alcohol allocation concealment ALT/AST Analysis Arm arrhythmia assigned Beta block-randomization Blood calculated Care center clinical Clinical improvement clinical trial conducted confirmed case control group cough COVID-19 COVID-19 confirmed patient COVID-19 in patient COVID-2019 Cox proportional-hazards model death discharge disease dissemination drug Duration education Effectiveness element eligibility enrolled excluded exclusion criteria fatigue follow-up time hazard headache Health hospital hospital discharge Hospitalization Hydroxychloroquine + Lopinavir/Ritonavir improvement include Interaction Interferon beta-1a Interferon-β 1a Interferon-β 1b intervals intervention group investigator Kaletra Kaplan–Meier laboratory result lactating women Last limit log-rank test Loghman Hakim Hospital Lopinavir Lopinavir/ritonavir masking mechanical ventilation Medical Science Medical Sciences moderate Mortality myalgia nasal NCT04343768 number objective open label Open-label Other outcome oxygen saturation package parallel group participant Patient performed positive pregnant Primary outcome primary outcome measure problem professional protocol pulse-oximetry R software R version 3.6.1 randomization randomization sequence Randomized Randomized controlled trial Randomly reached receive Recigen recruitment refusal regimen Registered Research respiratory rate RT-PCR test Sample SARS-CoV-2 sealed secondary secondary outcome seven-category ordinal scale single center single dose SpO2 sputum production standard care status Study protocol Symptom temperature tested the patient therapeutic three groups time treat treated treatment groups Trial university version 3.6.1 website World Health Organization Ziferon
[DOI] 10.1186/s13063-020-04382-3 PMC 바로가기 [Article Type] Letter

Effectiveness of Arbidol for COVID-19 Prevention in Health Professionals

의료 전문가의 COVID-19 예방을 위한 Arbidol의 효과

Public Health

Published on 2020-05-292022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 치료제,

[키워드] 95% CI Administered administration age Arbidol case-control study clinical Clinical and laboratory data collected Control COVID-19 cumulative diagnosed with COVID-19 drug females forms Health Health professional hospital Hospitalization Hospitalized incidence individual Infection laboratory data log-rank test male median age Mild symptom mild symptoms outbreak Patient populations prevention Primary prevention professional professionals Prophylactic prophylactically SARS-CoV-2 SARS-COV-2 infection significantly significantly higher subject the median Tongji Hospital treated uninfected Wuhan Wuhan, China
[DOI] 10.3389/fpubh.2020.00249 PMC 바로가기 [Article Type] Public Health

Risk factors for adverse clinical outcomes with COVID-19 in China: a multicenter, retrospective, observational study

Research Paper

Published on 2020-05-152022-10-28
Journal: Theranostics [Category] COVID-19, MERS, SARS,

[키워드] 95% CI Admission adverse event adverse events adverse outcome adverse outcomes Characteristics China Clinical outcome clinician collected Comorbidity coronavirus COVID-19 COVID-19 patient COVID-19 patients Cox regression Deceased demographic described discharged enrolled Factor hazard ratio help hospital ICU identify IMV In-hospital In-hospital death intensive care Invasive mechanical ventilation Kaplan-Meier plot Laboratory laboratory data laboratory-confirmed Leukocytosis log-rank test lymphopenia Mortality multicenter multiple comorbidities Multivariable regression analysis observation Older age outcome Patient patients Pneumonia Predictive primary endpoint retrospective risk factor secondary endpoint severity Support were used with COVID-19
[DOI] 10.7150/thno.46833 PMC 바로가기 [Article Type] Research Paper