RBD decorated PLA nanoparticle admixture with aluminum hydroxide elicit robust and long lasting immune response against SARS-CoV-2수산화알루미늄이 포함된 RBD 장식 PLA 나노입자 혼합물은 SARS-CoV-2에 대한 강력하고 오래 지속되는 면역 반응을 이끌어냅니다.Article Published on 2022-07-012022-09-12 Journal: European journal of pharmaceutics and biopharmaceu [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome aluminum antibody Antibody Response Antigen binding caused Characteristics circumvent Combination coronavirus COVID-19 COVID-19 vaccine develop E. coli elicit elicited expressed expression generate global pandemic hydroxide immune response immunization lactic acid limitations long-lasting mammalian memory Memory antibody response mimicking neutralization neutralize plaque Polymeric nanoparticles Protein-subunit vaccine provided RBD Receptor binding domain Result robust SARS-CoV-2 SARS-CoV-2 vaccine secondary antibody subunit Subunit vaccine Th1 Th2 Vaccine vaccine production virus infection Virus neutralization [DOI] 10.1016/j.ejpb.2022.05.008 PMC 바로가기 [Article Type] Article
Artificial intelligence and clinical data suggest the T cell-mediated SARS-CoV-2 nonstructural protein intranasal vaccines for global COVID-19 immunityDiscussion Published on 2022-07-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] artificial intelligence Clinical data COVID-19 COVID-19 immunity Immunity immunodominant intranasal long-lasting methodology mRNA vaccine nonstructural protein ORF1ab ORF3 ORF3a pathology peptide Protein SARS-CoV-2 SARS-CoV-2 protein suggested T cell Vaccine with COVID-19 [DOI] 10.1016/j.vaccine.2022.06.052 [Article Type] Discussion
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review
Humoral response to anti-SARS-CoV-2 vaccine in breastfeeding mothers and mother-to-infant antibody transfer through breast milk Research Published on 2022-06-232022-10-05 Journal: NPJ Vaccines [Category] 진단, [키워드] absence Anti-RBD IgG anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 vaccine antibody antibody production antibody transfer BNT162b2 vaccine breast milk Breastfeeding Humoral response IgA IgA2 IgG Infants long-lasting magnitude mother mucosal quantified retrieved Saliva serum stimulate swabs transfer vaccination Vaccine vaccine dose [DOI] 10.1038/s41541-022-00499-5 [Article Type] Research
The influence of time on the sensitivity of SARS-CoV-2 serological testingSARS-CoV-2 혈청 검사의 민감도에 대한 시간의 영향Article Published on 2022-06-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI Abbott anti-SARS-CoV-2 antibodies Antibody titer Antibody titers approach assays best booster vaccination collected Course days post infection demonstrated detect detectable diagnostic diagnostic sensitivity Elecsy evaluated Evidence evidence of follow-up period immune correlate immune correlates infected with SARS-CoV-2 Infection limitation long-lasting median Meso Scale Discovery MSD natural infection Neutralizing no evidence of nucleoprotein occurred Patient performed positive Probability proportion provide Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitive sensitivity serological test Serological testing Serological tests shown spike Spike protein Support survival survival time symptom onset the spike protein therapy time-to-event analysis Treatment [DOI] 10.1038/s41598-022-14351-2 PMC 바로가기 [Article Type] Article
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment증례 보고: SARS-CoV-2 감염이 오래 지속된 APDS 환자 1명에서 단일클론항체로 성공적인 치료Case Reports Published on 2022-06-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activated activated PI3K delta syndrome (APDS) administration affected APDS clearance COVID19 described Efficacy first positive genotyping IEI Infection LINE long-lasting long-lasting infection monoclonal monoclonal antibodies monoclonal antibody multiple therapeutic agent multiple therapeutic agents neutralizing monoclonal antibodies other treatments Patient pauci-symptomatic PI3K Prolonged reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Swab syndrome tested the SARS-CoV-2 virus therapeutic agents Tolerability treated Viral viral shedding virus wild type [DOI] 10.3389/fimmu.2022.891274 PMC 바로가기 [Article Type] Case Reports
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain healthReview article Published on 2022-06-202022-10-05 Journal: Trends in molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute phase Anosmia Brain cognitive COVID-19 COVID-19 cases Decreased downregulation dysfunction Evidence Health implication Inflammation likelihood long-lasting Mortality MOST neurological deficits Neuropathology occur Olfaction olfactory olfactory dysfunction pathology pathophysiology Quality of life question receptor proteins SARS-CoV-2 Smell loss structures Taste the SARS-CoV-2 virus [DOI] 10.1016/j.molmed.2022.06.005 [Article Type] Review article
Neurological sequela and disruption of neuron-glia homeostasis in SARS-CoV-2 infectionSARS-CoV-2 감염에서 신경교세포 항상성의 신경학적 후유증 및 붕괴Review Published on 2022-06-152022-09-12 Journal: Neurobiology of disease [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome Astrocyte autonomous Axon beta-coronavirus cause caused clinical presentation condition coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patients Cytokine storm death Diagnosis effective therapy Extracellular vesicles facilitate homeostasis immune system IMPROVE indicate Infection Injury intubation knowledge long-lasting microglia mitigate molecular Multi-organ damage Neuroinflammation neurologic neurological Neuron occur Oligodendrocyte Oligodendrocyte. outcomes pandemic pathology Pathomechanism Patient potential therapeutic target Prevent Respiratory failure responsible RNA SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 Infection single-stranded systemic inflammatory response tissue Treatment [DOI] 10.1016/j.nbd.2022.105715 PMC 바로가기 [Article Type] Review
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article
Comparison Between China and Brazil in the Two Waves of COVID-19 Prevention and ControlCOVID-19 예방 및 통제의 두 가지 물결에서 중국과 브라질의 비교Article Published on 2022-06-012022-09-11 Journal: Journal of Epidemiology and Global Health [Category] COVID19(2023년), SARS, 변종, [키워드] Brazil China conditions confirmed case confirmed cases Containment Containment measure Containment strategy Control cooperation country COVID-19 COVID-19 case COVID-19 cases cumulative cumulative death rate death case death rate effective Effectiveness Epidemic evaluate Factors Fighting indicate Intervention long-lasting measure Meteorological factor Mitigation Mitigation strategy much higher Multiple mutant strain Mutant strains National Perspective Policy Policy evaluation. premise prevention Prevention and control provide reached situation spread of COVID-19 the epidemic vaccination Wave [DOI] 10.1007/s44197-022-00036-6 PMC 바로가기 [Article Type] Article