lung cells – Page 5 – Communicable Diseases Research

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

TMPRSS2 발현에 대한 독특한 메커니즘은 엔잘루타미드에 의한 SARS-CoV-2 감염의 기관 특이적 억제를 설명합니다

Article

Published on 2021-02-082022-09-10
Journal: Nature Communications [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제,

ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues

ACE2 Nascence, 인신매매 및 SARS-CoV-2 발병 기전: 이야기는 계속됩니다

Review

Published on 2021-01-292022-09-10
Journal: Human Genomics [Category] 변종,

[키워드] ACE ACE2 addition administration Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Cell cell surface cellular coronavirus coronavirus disease COVID-19 death effective Efficiency effort evaluate explain highlight host cell human tissue human tissues in some Infection inhibitor initial internalization Invasion Localization lung cell lung cells mediator medication membrane missense variant modifications Neutralizing Novel coronavirus novel coronavirus SARS-CoV-2 pathway Pathways Perspective primary site reduce reducing reported required Research SARS-CoV-2 SARS-CoV-2 infections severe symptom severe symptoms severity shown subcellular localization the cell therapeutic strategy therapeutic target therapy Trafficking translational Viral virus
[DOI] 10.1186/s40246-021-00304-9 PMC 바로가기 [Article Type] Review

Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19

임상 분석 및 만능 줄기 세포 기반 모델은 COVID-19에 취약한 유아에 대한 ACE2 및 폐 전구 세포의 가능한 영향을 보여줍니다

Multicenter Study

Published on 2021-01-012022-09-01
Journal: Theranostics [Category] 진단, 치료기술,

[키워드] ACE2 ACE2 expression age Alveolar Type II analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsies Cell cells children children with COVID-19 clinical clinical feature Clinical features Cohort Combination contributing to cooperation coronavirus disease Coronavirus disease 2019 COVID-19 derivative develop developmental developmental stages disease severity distribution double positive cell double positive cells Ex vivo examined expressed expression expression level expression levels expression pattern expression patterns immune response immune system Impact Infant Infants infections lung lung biopsies lung cell lung cells lung development lung injuries Lung injury lung progenitor cells Lungs number of children Older pluripotent stem cells Pneumonia positive profiles progenitor cell progenitor cells reported risk factor Risk factors RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus severe coronavirus disease significantly single cell RNA sequencing SOX9 Spectrum Stage stem cell Type vulnerability with COVID-19
[DOI] 10.7150/thno.53136 PMC 바로가기 [Article Type] Multicenter Study

Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia

Research Article

Published on 2020-12-212022-10-28
Journal: PLoS ONE [Category] COVID-19, MERS,

[키워드] 95% CI 95% confidence interval ACE-2 ACEi ACEIs acute respiratory syndrome adjusted age Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB ARBs association blocker blockers comparison consecutive patient coronavirus coronavirus disease COVID-19 enzyme female group higher risk Hospitalized hypertensive patients inhibitors Interaction lung cells material modulated multivariable logistic regression Odds ratio Patient patients hospitalized patients treated patients with COVID-19 patients without COVID-19 Pneumonia polymerase chain propensity score analysis receptor Result retrospective risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection Significant tested Treatment two groups with COVID-19 women
[DOI] 10.1371/journal.pone.0244349 PMC 바로가기 [Article Type] Research Article

Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection

인간화 COVID-19 미끼 항체는 바이러스 침입을 효과적으로 차단하고 SARS-CoV-2 감염을 예방합니다

Article

Published on 2020-11-302022-09-11
Journal: EMBO Molecular Medicine [Category] SARS, 변종, 진단,

[키워드] abrogate ACE2 ACE2‐Fc activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin II antibody block cascade caused cells cellular receptor Characteristics circumvent coronavirus COVID‐19 COVID‐19 cytokine D614G variant D614G variants decoy antibody degranulation demonstrated develop domain effective enzyme fusion protein H1975 humanized immunology impairment Infection Interaction lung cell lung cells lung organoids Microbiology, Virology & Host Pathogen Interaction NK cell not affected pandemic peptidase preservation Prevent Pseudotyped virus reduce respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus shown Spike protein Strains therapeutic Treatment Viral viral entry viral spike protein virus infection virus replication virus variants
[DOI] 10.15252/emmm.202012828 PMC 바로가기 [Article Type] Article

The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link to Inflammation

COVID-19의 깔끔한 춤: NEAT1, DANCR 및 공동 조절 콜린성 RNA가 염증과 연결

Immunology

Published on 2020-10-092022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘,

[키워드] Accompanying ACE2 Acetylcholine acetylcholine signaling age Analysis association bioinformatics Blood Blood cells Brain candidate Cell culture cellular Central nervous system changes in cholinergic cholinergic neurons coding transcript coding transcripts cognitive Cohort Complication Consequences COVID-19 COVID-19 infection COVID-19 pandemic Dance DANCR Decline decrease diagnostic diagnostics donors expression followed by H1N1 H1N1 influenza human lung identify increase increases in infected cell Infection Inflammation Inflammatory Influenza inter-individual involved long non-coding RNA lung lung cell lung cells lung tissue lung tissues manifestation medication men and women MicroRNAs miRNA ncRNA ncRNAs NEAT1 Neurological complications Neuron non-coding RNA nuclear parasympathetic Post-infection predicted profiles qRT-PCR Quantitative reflected risk RNA RNA-seq dataset RNA-sequencing SARS-CoV-2 selected shifting Signaling statins Supporting susceptibility TFS therapeutic tissue tissue-specific expression tissues transcript transcription factor transcription factors transcriptomic transcripts Variability viruses weakened with COVID-19 woman
[DOI] 10.3389/fimmu.2020.590870 PMC 바로가기 [Article Type] Immunology

Peptides: Prospects for Use in the Treatment of COVID-19

Review

Published on 2020-09-242022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Cytokine Storm in COVID-19 Patients, Its Impact on Organs and Potential Treatment by QTY Code-Designed Detergent-Free Chemokine Receptors

Review Article

Published on 2020-09-232022-10-31
Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS,

[키워드] ACE2 receptor acute lung injury acute respiratory distress antibodies Blood blood vessel caused cells chemokine receptors COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine Cytokine storm Cytokine storms Cytokines death defend dialysis healthy Human human lung hyperinflammation Immune cell Impact infections Inflammatory inhibit injected intensive care kidney Kidney function kidneys liver lung cells Modification multiorgan failure Novel coronavirus organ organs oxygen Potential Potential treatment progression Protein released respiratory problems severe symptom storm syndrome transplants Wuhan
[DOI] 10.1155/2020/8198963 PMC 바로가기 [Article Type] Review Article

Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions

Genetics

Published on 2020-08-202022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

수용체 ACE2 발현에 대한 단일 세포 RNA-seq 데이터 분석은 2019-nCoV 감염에 취약한 다양한 인간 장기의 잠재적 위험을 보여줍니다

Research Article

Published on 2020-03-122022-09-06
Journal: Frontiers of medicine [Category] Communicable Disease, COVID-19, MERS, SARS,

[키워드] 2019-nCoV 2019-nCoV infection ACE2 ACE2 expression alveolar cell analyses Analysis analyzed angiotensin angiotensin converting enzyme AT2 bladder cell type cell types cells China dataset digestive enzyme II epithelial cells esophagus expression heart human cell human cells ileum kidney Kidney failure lung lung cell lung cells material Myocardial nCoV Novel coronavirus organ organs other organs Pathogenesis Patient physiological systems potential risk proximal tubule proximal tubule cell proximal tubule cells receptor receptor ACE2 respiratory reveal risk RNA-seq data route SARS-CoV scRNA-seq scRNA-seq data Single-cell RNA sequencing single-cell RNA-seq Symptoms target cell target cells vulnerability Wuhan
[DOI] 10.1007/s11684-020-0754-0 PMC 바로가기 [Article Type] Research Article