Long-Term Clinical and Immunological Impact of Severe COVID-19 on a Living Kidney Transplant Recipient – A Case ReportImmunology Published on 2021-09-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] anti-SARS-CoV-2 cellular clinical clinical decision COVID-19 demonstrated Deterioration discharge help Humoral immunity Immunity immunized immunocompromised individual immunological profile Impact infected with SARS-CoV-2 Injury kidney transplant living kidney transplant lung Lung fibrosis Lung injury male occurred Patient Pulmonary function reactivity recipient rejection renal renal tubular cells renal tubular injury report required SARS-CoV-2 virus severe COVID-19 suffered Transplant treated Treatment Vaccine Wuhan, China [DOI] 10.3389/fimmu.2021.741765 PMC 바로가기 [Article Type] Immunology
Low dose lung radiotherapy for COVID-19 pneumonia: A potential treatmentMini review Published on 2021-09-012022-10-05 Journal: Respiratory medicine [Category] SARS, 치료법, [키워드] acute respiratory syndrome affecting Anti-inflammatory Care country COVID-19 COVID-19 pneumonia cytokine detrimental dose Health immunomodulatory effect Inflammation low dose Low dose radiation therapy lung Lung fibrosis macrophages Most patient occur pandemic Potential treatment Radiotherapy reduce Respiratory disease risk SARS-CoV-2 pneumonia severely ill patients Side effect systemic inflammatory response therapy [DOI] 10.1016/j.rmed.2021.106531 [Article Type] Mini review
Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman PrimatesResearch article Published on 2021-09-012022-10-05 Journal: International journal of radiation oncology, biolo [Category] 비임상, [키워드] addition Analysis approach ATP12A BAL Biomarker Bronchoalveolar lavage CCL11 CCL2 CLDN10 collected Computed tomography dysregulated early phase epithelial cells Evolution expression GJB2 greater highlight histologic immunohistochemistry involved late phase LPA lung Lung fibrosis Lung injury lung tissue M2-like phenotype Macrophage macrophage polarization material mechanism molecular Mortality NHP NHPs occur Pathogenesis Plasma cytokine plasma samples potential therapeutic target primate progression protein expression provide Radiation radiation exposure respiratory rates Result rhesus RNA sequencing SERPINA3 Signaling TGF-β TGF-β1 TOX3 transcript transcriptomic analysis transcriptomic data Variability [DOI] 10.1016/j.ijrobp.2021.03.058 [Article Type] Research article
Lung Fibrosis after COVID-19: Treatment ProspectsReview Published on 2021-08-172022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] antifibrotic therapy Asymptomatic individuals caused clinical trial Community Complication complications contagious infection COVID COVID-19 death deupirfenidone diffusing drug candidates effective therapy effort fibrosis fraction impairment incidence incidence rate interstitial lung lung damage Lung fibrosis Lung pathology moderate morbidity MOST Nintedanib Novel coronavirus pathogen Patient Pirfenidone progression pulmonary damage pulmonary fibrosis reduction in rehabilitation remained respiratory complication respiratory manifestation SARS patient SARS-CoV-2 the disease the patient These data treamid Treatment Vaccine Vascular [DOI] 10.3390/ph14080807 PMC 바로가기 [Article Type] Review
The cytokines HGF and CXCL13 predict the severity and the mortality in COVID-19 patients사이토카인 HGF와 CXCL13은 코로나19 환자의 중증도와 사망률을 예측한다Article Published on 2021-08-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Admission anti-inflammatory properties anti-inflammatory property association B cell response best cellular chemokine Cohort cohorts Combination coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CXCL13 cytokine Cytokines death fibrosis Follow-up French hepatocyte growth factor HGF Host immune response ICU ICU admission identify immunological inflammatory pathways intensive care intensive care unit investigated Ligand likelihood Lung fibrosis lung tissue marker maturation mechanism Mortality motif Negative predictive value non-ICU non-ICU patients Occurrence over Patient patients pleiotropic positive power predict Predictive predictive values Prevent pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines pulmonary fibrosis reflect SARS-CoV-2 severe coronavirus disease severity significantly university up-regulation viral infection [DOI] 10.1038/s41467-021-25191-5 PMC 바로가기 [Article Type] Article
Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome A single center experience from Pune, Western IndiaCOVID-19 관련 사이토카인 방출 증후군 관리를 위한 토실리주맙과 스테로이드의 병용 요법 인도 서부 푸네의 단일 센터 경험4900 Published on 2021-07-232022-09-12 Journal: Medicine [Category] 진단, [키워드] Administered Admission Anti-inflammatory approved Bacterial bacterial and fungal infections blood stream Cardiac arrhythmia Clinical improvement co-morbidities co-morbidity combination therapy Complication conducted COVID-19 CRS Cytokine release syndrome Cytokine storm D-dimer death Dexamethasone effective Efficacy and safety Encephalopathy evaluate females fibrosis Fungal infection hospital Hospital acquired hypertension Hypotension ICU IL-6 incidence increased risk India Infectious complications inflammatory lung damage intensive care intensive care unit interleukin-6 interleukin-6 receptor lung damage Lung fibrosis management Mechanical mechanical ventilation morbidities Mortality not need outcome Patient patients patients with COVID-19 Pneumonia primary endpoint Randomized controlled trials receptor antagonist Relative risk required retrospective cohort study risk factor Safe secondary Secondary outcomes Seven severity significantly single center steroid Steroids syndrome TCZ therapy thought Tocilizumab Treatment Ventilation ventilator worsening [DOI] 10.1097/MD.0000000000026705 PMC 바로가기 [Article Type] 4900
Extension of Collagen Deposition in COVID-19 Post Mortem Lung Samples and Computed Tomography Analysis FindingsCOVID-19 사후 폐 샘플 및 컴퓨터 단층 촬영 분석 결과에서 콜라겐 침착의 확장Article Published on 2021-07-132022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval aeration Analysis analyzed collagen Computed tomography correlation correlations COVID-19 COVID-19 patient COVID-19 pneumonia Critically ill critically ill COVID-19 patients CT finding Deceased deposition detect extension fibrosis finding fixed formalin fraction histopathological Invasive mechanical ventilation investigated Lung CT Lung fibrosis median moderate paraffin patients with COVID-19 Pneumonia Postmortem Quantitative Radiographic Sample sensitivity Sirius specificity transbronchial [DOI] 10.3390/ijms22147498 PMC 바로가기 [Article Type] Article
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators런트 관련 전사 인자 1을 표적으로 하여 폐 섬유증을 예방하고 중증 급성 호흡기 증후군의 발현을 감소시킵니다 코로나바이러스 2 숙주 매개체Article Published on 2021-07-012022-09-12 Journal: The American journal of pathology [Category] MERS, 신약개발, 진단, [키워드] acute respiratory syndrome angiotensin-converting enzyme 2 causes coronavirus coronavirus 2 Critical current Disease progression downstream expression Factor FES fibroblasts fibrosis growth host protein human lung in vitro infections Inflammation inhibitor Lung epithelial cells Lung fibrosis mechanism mediator mice overexpress pathologic patients with HIV Pleiotropic effects pulmonary reduced reducing Region respiratory Respiratory complications Ro24-7429 RUNX1 Safe SARS-CoV-2 SARS-COV-2 infection subset targeting transcription factor Treatment tumor necrosis factor-α vascular endothelial cells [DOI] 10.1016/j.ajpath.2021.04.006 PMC 바로가기 [Article Type] Article
Short-Term Consequences of SARS-CoV-2-Related Pneumonia: A Follow Up StudySARS-CoV-2 관련 폐렴의 단기 결과: 후속 연구Article Published on 2021-07-012022-09-11 Journal: High blood pressure & cardiovascular prevention : [Category] SARS, 치료기술, [키워드] 4C mortality score alteration anorexia Anosmia Anxiety average baseline Brescia carbon monoxide Charlson Comorbidity Index clinical consequence clinical consequences Clinical outcome cohort study Comorbidity consequence COVID-19 demonstrated diffusing diffusing capacity discharge dysgeusia Dyspnea effort evaluated Evidence evidence of fatigue fibrosis Follow-up impairment indicated Indicator Insomnia Interstitial lung disease Italy life lung Lung disease Lung fibrosis lung involvement manifestation Mortality Patient persistence Pneumonia predict predicted prognostic Prognostic factors pulmonary fibrosis Quality of life radiologic Respiratory failure risk SARS-CoV2 Sequelae severity significantly survivor Symptom the disease the patient [DOI] 10.1007/s40292-021-00454-w PMC 바로가기 [Article Type] Article
Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseasesArticle Published on 2021-06-212022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] activity Acute myocardial infarction Analysis analyzed AUC Biomarker Biomarkers Cancer candidate Candidates clinically defined diagnostic Diagnostic markers disease Diseases expressed Gout healthy individuals Hepatic encephalopathy highest human disease human diseases investigated Ischemia lactate dehydrogenase LDH living cells Lung fibrosis MOST Patient prognostic Protein sensitivity serum significantly significantly increased specificity the healthy the median Treatment [DOI] 10.1038/s41598-021-92430-6 PMC 바로가기 [Article Type] Article