A colorimetric electronic tongue for point-of-care detection of COVID-19 using salivary metabolitesResearch article Published on 2022-08-012022-10-05 Journal: Talanta [Category] 치료기술, [키워드] Accuracy can be used category change colorimetric detection complexes Concentration COVID-19 COVID-19 patients cured detect diabete diagnose Donor Efficiency Evidence healthy healthy individuals identify individuals Kidney disease marker metabolite metabolomics Paper-based device participant Patient point-of-care receptor recorded rRT-PCR Saliva salivary Sensor array smoker tongue unique Viral load [DOI] 10.1016/j.talanta.2022.123537 [Article Type] Research article
Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress진단 후 6개월째 COVID-19 생존자의 심리적 결과: 우울증, 불안 및 스트레스에서 키누레닌 경로 대사물의 역할Article Published on 2022-08-012022-09-11 Journal: Journal of neural transmission (Vienna, Austria : [Category] MERS, 바이오마커, [키워드] 3-hydroxykynurenine Activation Admission alteration Anxiety anxiety symptom Biomarker Biomarkers both groups center change coronavirus disease Coronavirus disease 2019 correlation COVID-19 DASS-21 Depression depressive Depressive symptoms exhibited Follow-up healthy control healthy controls Hospitalization illnesses immune response immunologic response in both groups increase in Inflammation initial initial assessment Kynurenic acid Kynurenine Kynurenine pathway leads life mechanism Mental metabolism metabolite outcome pandemic participant pathophysiology pathway plasma Plasma levels post-COVID-19 patient Post-COVID-19 patients predicted predictor Psychiatric psychiatric disorder Psychiatric disorders questionnaire reduction in Stress Stress Scale survivor Symptom target therapy to define TRP Tryptophan Viral viral infection viral infections virus was used with COVID-19 [DOI] 10.1007/s00702-022-02525-1 PMC 바로가기 [Article Type] Article
Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2SARS-CoV-2에 대한 nitazoxanide의 항바이러스 활성의 전임상 평가Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] affected animal animal model antiviral activity antiviral efficacy antiviral therapy archive clinical trial Complete Concentration COVID-19 demonstrated diffusion Diseases dosage drug effective Efficacy European European Virus Archive Global Evidence evidence of France hamsters Horizon Human Human airway epithelium humans impair in vitro Infectious diseases intranasal metabolite National nitazoxanide not effective organ organs pharmacokinetic Pre-clinical research reconstructed Research SARS-CoV-2 SARS-CoV-2 virus Support supported Therapeutics tizoxanide Treatment union viral replication Wellcome Trust [DOI] 10.1016/j.ebiom.2022.104148 PMC 바로가기 [Article Type] Article
A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main ProteaseSARS-CoV-2 주요 프로테아제를 표적으로 하는 천연 잠재적 억제제에 대한 다단계 인실리코 연구Article Published on 2022-07-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] ADMET battle binding binding mode Characteristics choice co-crystallized Compound compounds conducted COVID-19 determine determined by DFT docking exhibited FIVE in silico in vitro in vivo inhibitor Ligand M pro main protease MD simulations metabolite metabolites molecular molecular docking molecular dynamics natural natural antiviral PDB PDB ID performed pharmacophoric positive Potential protease SARS-CoV-2 SARS-CoV-2 main protease selected similarity simulation studies Simulation study structural similarity Structure targeting the SARS-CoV-2 thermodynamic Toxicity was determined [DOI] 10.3390/ijms23158407 PMC 바로가기 [Article Type] Article
Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2네트워크 약리학 및 분자 도킹은 SARS-Cov-2로 인한 폐렴 치료에서 허브 호우 트 튜 니아 코타 타의 근본적인 약리학 적 메커니즘을 설명합니다.Article Published on 2022-07-212022-08-31 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity afzelin Analysis antiviral properties apigenin applied approach Asian caused China Combination docking DPP4 ELANE expression profiling Factor Herb herbal medicine High-throughput sequencing Houttuynia cordata HSP90AA1 IL6 ingredient integration involved Jak-STAT Japan kaempferol MAPK MAPK1 mechanism metabolite molecular molecular docking molecular dynamics Molecular dynamics simulation network network pharmacology NF-kB pharmacological pharmacological mechanism Pharmacology PI3K Pneumonia provide pulmonary infections quercetin reported required Research SARS-CoV-2 Sequencing SERPINE1 signaling pathways STAT suggested systemic level target therapeutic therapeutic effect therapeutic potential therapy treat treating [DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article
Chapter 12: Insight into coronaviruses and natural products-based approach for COVID-19 treatmentBook chapter Published on 2022-07-192022-10-05 Journal: Molecules [Category] 신약개발, 치료법, [키워드] Analysis Anticoronaviral natural products approach caused Contagion coronavirus Coronaviruses COVID-19 Defense disease drug effective humans include insight metabolite microbe molecular docking natural nontoxic pandemic of COVID-19 Pathogens performed plant Safe SARS-CoV-2 Secondary Metabolite shown Side effect specificity therapeutic targets Treatment [DOI] 10.1016/B978-0-323-91099-6.00005-0 [Article Type] Book chapter
Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severityCOVID-19 질병 중증도와 관련된 대사 산물, 단백질 및 조직 기능 장애Article Published on 2022-07-162022-09-11 Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] age Analysis anatomical approach biochemical pathway Biochemical pathways biological processe biological processes blood count blood count test changes in Characteristics clinical information complete blood count conjunction contribute COVID-19 Critical disease disease severity dysfunction Factor functional Gender Genome Health Health status Host Infection information Injury Interaction investigated liver lung machine learning algorithm Machine learning algorithms metabolite metabolites metabolomics molecular mechanism molecular mechanisms outcome Patient patient data predict presenting symptom profiles progression Protein proteomics provide response significant enrichment systemic inflammation tissue Treatment treatment of COVID-19 unstructured data with COVID-19 [DOI] 10.1038/s41598-022-16396-9 PMC 바로가기 [Article Type] Article
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses이중막 소포(DMV): SARS-CoV-2 및 기타 포지티브 센스 단일 가닥 RNA 바이러스 복제 전용 바이러스 유도 소기관Review Published on 2022-07-162022-09-11 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogy Antiviral approach autophagic biogenesis can not Cell organelle coronavirus COVID-19 Double-membrane vesicle Endoplasmic reticulum export Genome Golgi apparatus HCV hepatitis C hepatitis C virus host cell host cell membrane host cell membranes induce initial Innate immunity interactions involved lipid droplet lipid droplets lipids mechanism mechanisms membrane metabolite metabolites Mitochondria morphology non-structural protein organelle other coronavirus other coronaviruses pathogen phylogenetically positive-sense single-stranded RNA Positive-sense single-stranded RNA virus Replication replication of SARS-CoV-2 Replication organelle required RNA RNA virus SARS-CoV-2 sealed shown similarity single-stranded storage supply these viruses Vesicle viral replication Viral RNA virions virus Virus/cell interactions. viruses [DOI] 10.1007/s00018-022-04469-x PMC 바로가기 [Article Type] Review
An integrated analysis and comparison of serum, saliva and sebum for COVID-19 metabolomics Research Published on 2022-07-132022-10-05 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] alteration analysed Analysis biofluid Blood changes in Cohort correlation COVID-19 COVID-19 infection dominant dyslipidaemia hallmark hospitalised immunostimulatory Lipid majority metabolite metabolites metabolomics negative controls participant Pathologies pathophysiological conditions Patient performed plasma positive profile provided Saliva salivary Sebum sensitivity Sensitivity and specificity serum specificity Triglyceride utilised [DOI] 10.1038/s41598-022-16123-4 [Article Type] Research
Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity대사 모델링을 활용하여 COVID-19 질병 중증도와 관련된 기능적 대사 변경 식별Article Published on 2022-07-112022-09-11 Journal: Metabolomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute disease alteration approach claimed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic COVID-19 sample COVID-19 samples disease Disease progression disease severity driver dysfunction functional Genome Genome-scale metabolic modeling healthcare highlight histidine hospital Hospitalization Host identify immunopathology Increased Infection Inflammation Inflammatory Inflammatory response innate immune response innate immune system Invasion investigated ketone lung damage machine machine learning marker mechanism metabolic pathway metabolism metabolite metabolomics muscular Musculoskeletal offer pathway Pathway enrichment analysis patients plasma metabolome positive Predictive Prevalence Prevent reduce SARS-CoV2 SARS-CoV2 infection severe COVID-19 Severe infection Tryptophan University of Virginia viral replication Virginia weakness with COVID-19 [DOI] 10.1007/s11306-022-01904-9 PMC 바로가기 [Article Type] Article