metabolome – Page 5 – Communicable Diseases Research

A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure

Article

Published on 2021-05-182022-10-04
Journal: Scientific Reports [Category] 바이오마커,

The faecal metabolome in COVID-19 patients is altered and associated with clinical features and gut microbes

COVID-19 환자의 대변 대사체가 변경되어 임상 특징 및 장내 미생물과 관련이 있습니다.

Article

Published on 2021-04-012022-09-11
Journal: Analytica chimica acta [Category] SARS, 치료기술,

[키워드] absorbed Absorption Actinomyces age alteration analysed Analysis Aspergillus behenic acid butylphenol can not clinical feature Clinical features clinical information Cohort collected component Compound conducted correlated correlation COVID-19 COVID-19 patient COVID-19 patients D-pinitol digestion discharge discharged patient discharged patients faece Faeces fatty gas chromatography Gas Chromatography-Mass Spectrometry glycerol greater Gut HCs healthy control healthy controls healthy subject hospital humans hypoxanthine intestinal inflammation intestine Malnutrition mass spectrometry metabolite metabolites metabolome microbe microbiota Mycobiota not different oxalate Pathogenesis pinitol purine SARS-CoV-2 serum significantly Spearman sucrose the patient Treatment treatment of COVID-19 validation cohort
[DOI] 10.1016/j.aca.2021.338267 PMC 바로가기 [Article Type] Article

Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptome

Article

Published on 2021-04-012022-10-04
Journal: Scientific Reports [Category] 바이오마커,

Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

COVID-19 환자의 대사체 분석은 단계 의존적 및 예후 바이오마커를 밝힙니다.

Clinical Trial

Published on 2021-03-112022-08-13
Journal: Cell Death & Disease [Category] SARS, 바이오마커, 임상, 진단,

[키워드] alteration amino acids Analysis anthranilic acid circulating metabolome cohort of patient COVID-19 COVID-19 patient COVID-19 patients Critical Critical disease derivatives disease Diseases Elevation Evolution Hospitalization immunosuppressive properties individual Indoleamine 2,3-dioxygenase inhibit intensive care intensive care unit interleukin-10 interleukin-10 and -18 Kynurenine Kynurenine pathway lipids maintenance metabolite metabolome metabolomics Mild mild COVID-19 patients moderate moderate disease organism oxygen Oxygen therapy oxygen therapy) pathogenic challenges pathway physiological state plasma plasma metabolome Pneumonitis polyamines prognostic biomarker Prognostic value provide rate-limiting enzyme rate-limiting enzymes required single metabolite sugars therapeutic utility Tocilizumab transfer Tryptophan tryptophan 2,3-dioxygenase viral infection
[DOI] 10.1038/s41419-021-03540-y PMC 바로가기 [Article Type] Clinical Trial

SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome

Article

Published on 2021-03-052022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

COVID-19의 대사체/지질체 프로파일링 및 토실리주맙에 대한 개별 반응

Research Article

Published on 2021-02-012022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, 진단,

[키워드] absence Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting age age- and sex-matched controls alteration Analysis analyzed approach biochemical caused change changes in characterized Clinical data clinical manifestations Clinical symptoms Control control group controls coronavirus disease Coronavirus-2 correlation correlations COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients determinant EDTA evaluated First wave Florence form global health Health heterogeneity humanized monoclonal antibody induce Infection intensive care treatment interleukin-6 interleukin-6 receptor Italy Magnetic resonance spectroscopy metabolite metabolome metabolomic metabolomics MONITOR NMR-based metabolomic and lipidomic profiling Novel coronavirus novel coronavirus disease nuclear nuclear magnetic resonance open outcomes pandemic pathophysiological mechanism Patient patients patients hospitalized plasma plasma-EDTA sample plasma-EDTA samples provide recombinant humanized monoclonal antibody respiratory response to treatment SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 small-molecule profile subset Symptom the disease Tocilizumab tocilizumab administration Treatment treatment with tocilizumab world population
[DOI] 10.1371/journal.ppat.1009243 PMC 바로가기 [Article Type] Research Article

Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020

Meeting Report

Published on 2021-01-042022-10-29
Journal: Microbiome [Category] COVID-19,

[키워드] Autism Spectrum Disorder Behavior connection Fecal microbiota transplants Gut-brain axis Health healthcare implication Live biotherapeutic products metabolome Microbiome multiple sclerosis Radiation Research Sequencing Spaceflight took place Travel
[DOI] 10.1186/s40168-020-00951-5 PMC 바로가기 [Article Type] Meeting Report

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

Article

Published on 2020-10-082022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커,

Enrofloxacin Shifts Intestinal Microbiota and Metabolic Profiling and Hinders Recovery from Salmonella enterica subsp. enterica Serovar Typhimurium Infection in Neonatal Chickens

엔로플록사신은 장내 미생물 군집과 대사 프로파일을 변화시키고 신생아 닭에서 살모넬라 엔테리카 서브스피시스 엔테리카 세로바 Typhimurium 감염으로부터의 회복을 방해한다.

Research Article

Published on 2020-09-092024-07-29
Journal: mSphere [Category] 살모넬라증,

[키워드] chicken enrofloxacin gut microbiota metabolome Salmonella
[DOI] 10.1128/mSphere.00725-20 PMC 바로가기 [Article Type] Research Article

Δ9-Tetrahydrocannabinol Prevents Mortality from Acute Respiratory Distress Syndrome through the Induction of Apoptosis in Immune Cells, Leading to Cytokine Storm Suppression

Article

Published on 2020-08-282022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] Δ9-tetrahydrocannabinol Activation acute respiratory distress syndrome addition amino acids Analysis analyzed Apoptosis apoptotic ARDS attenuate BALF Bronchoalveolar lavage fluid Carnitine cause caused Cell Concentration correlated COVID-19 COVID-19 patient cytokine Cytokine storm database disease downregulation elevated enzyme gene expression dataset Human Immune cell increase in induction L-carnitine leading lung Lung inflammation lysine mechanism metabolome metabolomic analysis methionine mice mitochondrial Mortality pathway performed pro-apoptotic receptor respiratory SEB serum signaling pathway similarity Single-cell RNA sequencing staphylococcal enterotoxin B storm suggested suppression survival targets therapeutic Transcriptome transcriptomic analysis treat treated Treatment Trigger was used were used with COVID-19
[DOI] 10.3390/ijms21176244 PMC 바로가기 [Article Type] Article