Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila미세 조정 autophagy는 수명을 최대화하고 초파리의 미토콘드리아 유전자 발현 변화와 관련이 있습니다Research Article Published on 2020-11-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated Amino acid applied approach Atg1 Atg5 autophagy block cellular cellular pathway changes in characteristic conditions conserved Critical damaged Degradation degrade Deletion detrimental disease down-regulated down-regulation downregulation Drosophila Effect energy expression extension feature Glucose Health healthy help highlight immune system IMPROVE in vivo increase in Increased insulin insulin receptor Intervention leads Longevity metabolism metabolomic Mild mitochondrial mitochondrial gene mitochondrial genes mitochondrial metabolism moderate Moderation organelle over-expressing overexpression pathway Pathways phenotype Phenotypes profile proteasomal Protein Rapamycin receptor reduced Research short-lived signature transcriptional profile Transcriptional upregulation triacylglycerol up-regulated up-regulation upregulated upregulation [DOI] 10.1371/journal.pgen.1009083 PMC 바로가기 [Article Type] Research Article
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2Article Published on 2020-11-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Analysis approach arachidonic acid AUC Biomarkers characterized circulating control groups coronavirus correlated COVID-19 COVID-19 patient death Degradation Effect Evidence fatty acids free fatty acids Host host response Infection key factor Lipid mechanism metabolism metabolomic metabolomics molecule New Pathogenesis pathogenesis of COVID-19 Phosphatidylcholine Phospholipase A2 plasma porphyrins potential biomarkers provide provided response Revealed SARS-CoV-2 SARS-COV-2 infection severity spread to target the disease Therapeutic strategies therapeutic target therapeutic targets Triglyceride tyrosine [DOI] 10.3390/ijms21228623 PMC 바로가기 [Article Type] Article
The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolismArticle Published on 2020-10-082022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, [키워드] analyzed Biomarkers cell metabolism Control coordinator cytosine described Diagnosis diagnosis of SARS-CoV-2 diagnostic early diagnosis evaluated Evolution explained feasibility generate IMPROVE independent infected with SARS-CoV-2 Infection inflammatory signal involved knowledge mechanism metabolism metabolome metabolomic metabolomics microbiota multivariate model pathway Patient Perspective plasma metabolome predict prognostic biomarker SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient sensitivity Support targets the disease therapeutic Virology [DOI] 10.1038/s41598-020-73966-5 PMC 바로가기 [Article Type] Article
Plasma metabolomic and lipidomic alterations associated with COVID-19Special Section: SARS-CoV-2 Published on 2020-07-282022-10-30 Journal: National Science Review [Category] COVID-19, [키워드] addition affected alteration analysis CD73 changed cohort of patient coronavirus disease correlation Course COVID-19 died disease down-regulated energy metabolism global public health GMP guanosine monophosphate healthy subject hepatic dysfunction knowledge lipidome malic acid metabolism metabolite metabolome metabolomic Mild mild symptoms pandemic pathogenesis of COVID-19 Patient patients patients with COVID-19 performed phosphate physiological change plasma plasma biomarker potential therapeutic targets provide resource SARS-CoV-2 severity of COVID-19 significantly Symptoms symptoms of COVID-19 TCA cycle urea cycle with COVID-19 [DOI] 10.1093/nsr/nwaa086 PMC 바로가기 [Article Type] Special Section: SARS-CoV-2
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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after InfectionArticle Published on 2017-08-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] administration alterations Altered analysis Cardiovascular disorders clinical Clinical treatment Diseases Effect examination finding Glucose Health healthy controls High-dose indicated Infection infections information investigated Lipid lung metabolism metabolome metabolomic Methylprednisolone Pathologies Patient provided pulse questionnaire recovered recruited response SARS patient SARS patients SARS-CoV SARS-like coronavirus serum severe pneumonia significant difference suggested Survivors susceptibility systemic damage the patient treated tumors Year [DOI] 10.1038/s41598-017-09536-z PMC 바로가기 [Article Type] Article