SARS-CoV-2 neutralizing antibodies in patients with varying severity of acute COVID-19 illness다양한 중증도의 급성 COVID-19 질병 환자의 SARS-CoV-2 중화 항체Article Published on 2021-01-212022-09-01 Journal: Scientific Reports [Category] MERS, 진단, 치료기술, 치료법, [키워드] acute COVID-19 illness Adaptive immunity antibody association Asymptomatic clinical disease convalescence Convalescent plasma therapy COVID-19 illness declined evaluate faster immunology individual Infection Infectious diseases Kinetics less Medical research Microbiology Mild mild illness moderate Moderate COVID-19 NAb NAbs neutralization test Neutralizing antibodies Pathogenesis Patient persistence SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody severity severity of illness significantly Support Vaccine development Viral viral neutralization virus [DOI] 10.1038/s41598-021-81629-2 PMC 바로가기 [Article Type] Article
Covid-19 in Children and Young Adolescents in Al Ain, United Arab Emirates- a Retrospective Cross-Sectional StudyPediatrics Published on 2021-01-182022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] 2019-nCoV absolute neutrophil count acute respiratory distress Admission Adolescent age Al Ain Asthma Chest computed tomography chest X-ray children city Cohort Comorbidity coronavirus cough COVID-19 death Diagnosis discharged Fever highest hospital Hospital stay ICD-10 Infection invasive respiratory support Lower respiratory tract median medical record mild illness MOST Neurological symptoms noninvasive respiratory Patient Platelet Prevalence required retrospective SARS-CoV2 Sepsis Septic shock Seven single-center study study period Support Symptom syndrome those with comorbidities United Arab Emirates upper respiratory tract [DOI] 10.3389/fped.2020.603741 PMC 바로가기 [Article Type] Pediatrics
Symptoms and recovery among adult outpatients with and without COVID‐19 at 11 healthcare facilities—July 2020, United StatesOriginal Article Published on 2021-01-062022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] COVID-19, SARS, [키워드] 95% confidence interval adjusted odds ratio adult outpatient Affect Anosmia body aches Control control patient convalescence COVID‐19 COVID‐19 diagnostic Duration Effect evaluated fatigue Fever Health healthcare illness illness duration Influenza logistic regression model Loss Measures mental health Mild mild illness multivariable logistic regression negative controls participant Patient persistent physical presenting Quality of life recovery reported Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 significantly more Symptom symptom onset Symptoms symptoms duration tested the United State United State weakness widespread [DOI] 10.1111/irv.12832 PMC 바로가기 [Article Type] Original Article
Associations between hematological parameters and disease severity in patients with SARS-CoV-2 infectionSARS-CoV-2 감염 환자의 혈액학적 매개변수와 질병 중증도 간의 연관성Article Published on 2021-01-012022-08-31 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Analysis analyzed association Biomarker Biomarkers Blood cells calculated caused characteristic characterized complement coronavirus coronavirus disease diagnostic disease disease severity distribution Health crisis hematological parameter hematological parameters hematological parameters. high risk highest identify independent Infection Inflammatory responses lymphocyte Lymphocyte count marker mean platelet volume measure Mild disease mild illness moderate monocyte Multivariate analysis neutrophil neutrophil counts Neutrophil-to-lymphocyte ratio NLR Novel coronavirus novel coronavirus disease Older age parameter parameters Patient patients with SARS-CoV-2 Platelet Platelet count Predictive predictive values progression public health crisis receiver receiver operating characteristic Red cell regression analysis respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Spread subpopulations Univariate analysis Volume WBC WBCs were used White blood cell White blood cells with mild disease [DOI] 10.1002/jcla.23604 PMC 바로가기 [Article Type] Article
The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemicCOVID-19 전염병 동안 어린이의 다기관 염증 증후군의 잠재적 위협Article Published on 2021-01-012022-09-11 Journal: Pediatric allergy and immunology : official public [Category] MERS, SARS, 진단, 치료기술, [키워드] ADE anti-SARS-CoV-2 antibodies antibody Antibody-dependent enhancement Asymptomatic case Asymptomatic cases center changes children conjunctivitis Control correlated COVID-19 COVID-19 pandemic detectable anti-SARS-CoV-2 antibody diarrhea disease disease control edema Fever in some incidence include Inflammatory Kawasaki syndrome manifestation membrane mild illness MIS MIS-C moderate mucous membrane multi-organ failure Multisystem inflammatory syndrome network pathogen pathogen-specific pathology pediatric prevention progressed progression promote raised Rash SARS-CoV-2 severe inflammatory state Shock syndrome these symptom these symptoms Vaccine development [DOI] 10.1111/pai.13361 PMC 바로가기 [Article Type] Article
Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational studyObservational Study Published on 2021-01-012022-10-04 Journal: Journal of cystic fibrosis : official journal of t [Category] MERS, SARS, 임상, [키워드] age analysed Antibiotics antiviral treatments body mass index Characteristics children clinical Clinical course co-morbidities Community Corticosteroids country COVID-19 COVID-19 disease COVID-19 illness cystic fibrosis Deterioration died expiratory fibrosis FIVE group harmonization hospital hospitalised International interquartile range less Lung disease Lung function majority male median mild illness non-invasive ventilation positive predicted reduced registry required respiratory problems Result risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease supplementary oxygen Volume [DOI] 10.1016/j.jcf.2020.11.021 PMC 바로가기 [Article Type] Observational Study
Complement Inhibition in Severe COVID-19 Acute Respiratory Distress SyndromePediatrics Published on 2020-12-292022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Acute kidney injury acute lung injury acute respiratory distress acute respiratory distress syndrome (ARDS) AKI animal model ARDS Asymptomatic children children with COVID-19 complement convalescent plasma COVID - 19 COVID-19 Critically ill Deterioration died disease eculizumab Immune-mediated inflammatory pathways inhibition lung Lung function lung tissue mild illness MOST patients with COVID-19 pediatric respiratory SARS-CoV SARS-CoV-2 supported syndrome treated with COVID-19 [DOI] 10.3389/fped.2020.616731 PMC 바로가기 [Article Type] Pediatrics
Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome질병 중증도 및 결과와 관련된 SARS-CoV-2 감염에 대한 항체 반응의 특징 및 기간 정의Research Articles Published on 2020-12-072022-09-10 Journal: Science Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 acute illness Affect analyzed angiotensin angiotensin-converting enzyme 2 antibody antibody levels Antibody Response Antibody responses Asymptomatic Asymptomatic individuals Clinical outcome clinical outcomes Cohort correlated COVID-19 COVID-19 patients decrease decreases disease severity ELISA feature FIVE hospitalized COVID-19 patient Host IgG IgG antibodies IgG antibody IgG titer illness Illness severity in viral increase Interaction mild illness Most patients Neutralization assay neutralize nucleocapsid antigen observation outcome outcomes Outpatient outpatients Patient patients patients died plasma antibody plasma sample Post-infection predict Pseudovirus neutralization assays RBD RBD domain RBD-ACE2 receptor Receptor binding domain responses SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2-specific antibodies serological serological response severely ill patients severity specific antibodies specificity Viral viral spike virus [DOI] 10.1126/sciimmunol.abe0240 PMC 바로가기 [Article Type] Research Articles
Similarities and differences between the ‘cytokine storms’ in acute dengue and COVID-19급성 뎅기열의 '사이토카인 폭풍'과 코로나19의 유사점과 차이점Article Published on 2020-11-162022-09-12 Journal: Scientific Reports [Category] 진단, [키워드] antiviral response CD40 chemokine cohort of patient contributing to COVID-19 COVID-19 patient COVID-19 patients Critical cytokine Cytokines Dengue Dengue fever dengue haemorrhagic fever determine develop DHF different time point different time points disease disease severity early disease evaluated febrile Fever IFNγ IL-10 IL-6 IL-6 level IL-6 levels immune response immunology immunosuppressive infecting infections Level lowest Microbiology mild illness moderate-to-severe COVID-19 Multiorgan dysfunction Patient Pneumonia remained response SARS-CoV2 serum severe pneumonia severity of COVID-19 significantly higher significantly increased similarities similarity virus with COVID-19 [DOI] 10.1038/s41598-020-76836-2 PMC 바로가기 [Article Type] Article
Dynamics of CD4 T Cell and Antibody Responses in COVID-19 Patients With Different Disease SeverityMedicine Published on 2020-11-112022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute infection acute respiratory syndrome adaptive Adaptive immunity antibody Antibody Response blood sample caused CD4 CD4 T cell Cohort collected combating coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-reactive death described detectable disease severity Dynamics group Hospitalization IgG IgM immune Immunity individuals mild illness moderate neutralization neutralizing antibody no significant difference parameter patients with moderate response responses robust SARS-CoV-2 SARS-CoV-2-specific antibodies SARS-CoV-2-specific T cells severe disease severe respiratory disease symptom onset T cell response the patient the timing therapy Viral load viral loads virus [DOI] 10.3389/fmed.2020.592629 PMC 바로가기 [Article Type] Medicine