Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein UbiquitinationArticle Published on 2022-08-292022-11-16 Journal: Medical science monitor : international medical jo [Category] 유전자 메커니즘, [키워드] Analysis ASB16 biological process Cell Characteristics Cluster conducted core gene COVID-19 COVID-19 pandemic DEGs detect differentially expressed gene enrichment evaluate expressed facilitate FBXO11 FOXA1 FOXC1 functional GATA2 Gene expression analysis Genes healthy controls hsa-miR-1-3p identify Interaction ITCH macrophages miRNA molecular mononuclear cell Patient performed peripheral Peripheral blood platform progression protein ubiquitination protein-protein interaction regulate Regulating Regulatory response RNA sequencing RNF130 severe COVID-19 signaling pathways single-cell transcription factors Transcriptome TRIM21 UBE2J1 was used were expressed YY1 [DOI] 10.12659/MSM.937532 PMC 바로가기
Plasma microRNA and metabolic changes associated with pediatric acute respiratory distress syndrome: a prospective cohort study Research Published on 2022-08-262022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] acute respiratory distress ARDS Bacterial infection Biomarker Biomarkers both groups change circulating circulation Clinical characteristics conducted control patient correlated Critically ill defined differential expression differentially expressed distress evaluate heterogeneous identify intensive care patients metabolite metabolomics microRNA MicroRNAs miRNA miRNA expression morbidity and mortality non-coding RNA pathophysiological Patient pediatric Pediatric patient Pediatric patients pilot study prognostic biomarker progression prospective cohort study provide Random forest random forest classification responsible risk selected single-center sub-cohort subset syndrome therapeutic intervention [DOI] 10.1038/s41598-022-15476-0 [Article Type] Research
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
Fluorescent Platforms for RNA Chemical Biology ResearchRNA 화학 생물학 연구를 위한 형광 플랫폼Review Published on 2022-07-272022-09-11 Journal: Genes [Category] 치료제, [키워드] activities activity applied assays binding Biology Biotin change Chemical Chemical biology Clinical research clinically COVID-19 test COVID-19 tests CRISPR Degradation demonstrated detect Drug discovery drugs targeting Efficacy Efficiency efficient energy transfer ENhance enzyme Enzyme labeling example facilitate fit Fluorescence fluorescence anisotropy Fluorescence imaging fluorescent fluorescent assays. Forced In situ hybridization increase invention lAbel labeling living cells Mango microRNA miRNA movement mRNA ncRNAs non-coding RNA Non-coding RNAs Nuclease observation overcome probe Research ribonucleoprotein RNA ROI subcellular T-box tumors [DOI] 10.3390/genes13081348 PMC 바로가기 [Article Type] Review
MicroRNAs as Potential Tools for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2 Infection and Vaccination ResponseSARS-CoV-2 감염 및 백신 접종 반응에 대한 암 환자의 감수성을 예측하기 위한 잠재적 도구로서의 MicroRNAReview Published on 2022-07-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 Antiviral Biomarkers Cancer Cancer patients caused cellular processes contagious COVID-19 Defense deregulated deregulation described disease dysregulated expression genetic information global pandemic human infection immune immune response impair Infection Infectious disease key factor malignancies miR-223-3p miRNA miRNA profile miRNAs mRNA vaccine mRNAs Potential prognostic biomarker Regulation response SARS-CoV-2 SARS-CoV-2 replication Seven spike glycoproteins Spread treatment strategy Vaccine Vaccines [DOI] 10.3390/cells11152279 PMC 바로가기 [Article Type] Review
The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infectionCOVID-19의 발병기전에서 miRNA의 새로운 역할: SARS-CoV-2 감염에 대한 기능식품 폴리페놀 화합물의 보호 효과Review Published on 2022-07-182022-09-11 Journal: International Journal of Medical Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accumulating acting acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 attenuate Clinical efficacy Compound coronavirus coronavirus 2 Coronaviruses COVID-19 Cytokine storm death Diagnosis diagnostic drug Effect Evidence expression Host host cell host cells immune response Immunosuppression implication Infection life cycle lung damage MicroRNAs miRNA miRNA expression miRNAs modulating outcome Pathogenesis patients with SARS-CoV-2 prognostic biomarker Prognostic biomarkers PROTECT protein-coding genes RNA RNA transcript SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 replication Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Treatment treatment of COVID-19 viral entry viral replication [DOI] 10.7150/ijms.76168 PMC 바로가기 [Article Type] Review
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
Bioinformatics analyses reveal cell-barrier junction modulations in lung epithelial cells on SARS-CoV-2 infectionArticle Published on 2022-07-032023-07-07 Journal: Tissue Barriers [Category] COVID19(2023년), [키워드] cell junctions claudins COVID-19 cytoskeleton miRNA MMP SARS-CoV-2 [DOI] 10.1080/21688370.2021.2000300 PMC 바로가기
MicroRNAs in the development of potential therapeutic targets against COVID-19: A narrative reviewReview article Published on 2022-07-012022-10-05 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 바이오마커, 변종, 치료제, [키워드] ACE2 ACE2 receptor ACE2 receptors Antiviral biogenesis cellular miRNAs change chemokines collected complex conducted consequence COVID-19 cytokine Cytokines database Degradation Deleterious effective evaluate expression Extensive function generate Google help host response immune system include Infection infection process information inhibiting Interaction involved latency microRNA miRNA miRNAs Modification modulate Pathogenesis platform potential therapeutic target Prognosis reduce reduced regimen Regulation Regulatory Result SARS-CoV-2 SARS-COV-2 infection Science Direct Scientific community secretion Side effects Specific the SARS-CoV-2 therapeutic therapeutic target therapeutic targets Therapeutics therapy threat viral infection Viral load viral replication Viral RNA virus website WHO [DOI] 10.1016/j.jiph.2022.06.012 [Article Type] Review article