motif – Page 5 – Communicable Diseases Research

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다

Article

Published on 2022-07-092022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

Comparative genomic analysis of the human genome and six bat genomes using unsupervised machine learning: Mb-level CpG and TFBS islands

비지도 머신 러닝을 사용한 인간 게놈과 6개의 박쥐 게놈 비교 게놈 분석: Mb 수준 CpG 및 TFBS 섬

Comparative Study

Published on 2022-07-082022-09-11
Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] 3D structure 3D Structures addition Algorithm Analysis artificial artificial intelligence bat bats binding Centromeric heterochromatin characteristic Characteristics chromosomes class Clustering Comparative conducted contributing to CpG diagnostic dinucleotide disease-causing distribution Ebola Emerging infectious disease feature Features function Gene Expression Genome genomes genomic Genomic analysis help hosts Human Human genome humans Infectious disease information Interaction involved knowledge machine machine learning motif natural reservoir nuclear oligonucleotide Oligonucleotide composition oligonucleotides Protein Region regions Regulation reveal RNA viruses SARS-CoV-2 self-organization Self-organizing map Self-organizing map. sequence TFS the SARS-CoV-2 thought transcription factor transcription factors variety virus viruses zoonotic
[DOI] 10.1186/s12864-022-08664-9 PMC 바로가기 [Article Type] Comparative Study

The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2

단량체 C 반응성 단백질의 콜레스테롤 결합 서열은 SARS-CoV-2 스파이크 수용체 결합 도메인에 결합하고 안지오텐신 전환 효소 2와의 상호 작용을 차단합니다

Article

Published on 2022-07-082022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids angiotensin bind binding block C-reactive protein C-reactive protein (CRP CBS Cell cell surface Characteristics cholesterol cholesterol-binding sequence clinical coronavirus COVID-19 pathogenesis Critical CRP CRP level CRP levels diagnostic domain experiment functional highlight human Angiotensin-converting enzyme Inflammation inhibit Innate immunity Interaction involved marker monomeric monomeric C-reactive protein motif mutant overexpressed Pathogenesis patients with COVID-19 Pattern recognition pattern recognition receptor pattern recognition receptor. peptide provide RBD receptor Receptor-binding domain reduced SARS-CoV-2 SARS-CoV-2 Spike RBD sequence severe acute respiratory syndrome Coronavirus spike Spike protein surface plasmon surface plasmon resonance the SARS-CoV-2 the spike protein therapeutic virus
[DOI] 10.3389/fimmu.2022.918731 PMC 바로가기 [Article Type] Article

Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis

소아 및 장기 코로나의 다기관 염증 증후군: SARS-CoV-2 바이러스 초항원 가설

Article

Published on 2022-07-072022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] addition Alter attribute autoantibodies autoantibody autoimmune responses Autoimmunity Bacterial binding Cell change children children with MIS-C circulating computational studies conjunctivitis conserved contribute COVID COVID-19 develop elevated exposure to feature febrile Fever Gastrointestinal glycoprotein Gut high affinity hyperinflammation immune response Immunosequencing Inflammatory inflammatory disease initial Kawasaki disease Long Long COVID MHC class II MHC Class II proteins MIS-C MIS-C multisystem inflammatory syndrome in children motif Multiorgan Neurological complication Neurological complications Neurological symptom Neurological symptoms neuronal neurotoxin neurotoxin-like segment oral mucosa PASC Patient patients pediatric Peripheral blood peripheral blood samples persistence persistent fever Post-acute sequelae of COVID-19 (PASC) prolonged exposure promote Proteins rashes resulting SAgs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 spike SARS-CoV-2 virus SEB Sequence analysis serum cytokine levels severity Shock similarity staphylococcal enterotoxin staphylococcal enterotoxin B strawberry strawberry tongue Structure superantigen superantigen-like motif. syndrome systemic hyperinflammation T-cell receptor TCR TCRs the SARS-CoV-2 the SARS-CoV-2 virus Toxic shock Toxic shock syndrome TRBV11-2 triggered TSS unique β variable
[DOI] 10.3389/fimmu.2022.941009 PMC 바로가기 [Article Type] Article

Structural basis for inhibition and regulation of a chitin synthase from Candida albicans

Research

Published on 2022-07-042022-10-05
Journal: Nature Structural & Molecular Biology [Category] 변종,

[키워드] binding Candida albican chitin conserved Control cryo-EM structure enzyme activity Extracellular fungal cell wall inhibitor mechanism membrane motif non-specific Prevent Regulation Synthase target translocation unique
[DOI] 10.1038/s41594-022-00791-x [Article Type] Research

Self-derived peptides from the SARS-CoV-2 spike glycoprotein disrupting shaping and stability of the homotrimer unit

SARS-CoV-2 스파이크 당단백질의 자가유래 펩타이드가 동종삼량체 단위의 형태와 안정성을 방해

Article

Published on 2022-07-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종,

[키워드] approach binding binding affinity blocker blockers conformation COVID dataset destabilized develop disrupting domain exhibited functional higher affinity homotrimer host cell host cell receptor instability linear Linear motif molecular molecular dynamics monomer motif mutated Mutation opposite peptide peptides Protein protein structure RBD Region regions responsible resulting S protein S1 and S2 S1 and S2 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 S Self-derived peptides shown spike spike glycoprotein stability Structural folding structure-based design subunit Support the S protein the SARS-CoV-2 Vaccine Vaccine design variant wild type β-coronavirus
[DOI] 10.1016/j.biopha.2022.113190 PMC 바로가기 [Article Type] Article

A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

상어 유래 단일 도메인 항체 클래스는 SARS 관련 코로나바이러스와 중화 및 오미크론 탈출의 구조적 기초를 광범위하게 중화할 수 있습니다

Article

Published on 2022-07-012022-09-11
Journal: Small methods [Category] COVID19(2023년), SARS, 변종,

[키워드] administration affinity Alpha antibodies antibody Basis bat Beta beta variants bind binding class complementary conserved coronavirus Delta disrupt domain epitope escape hidden impair Interaction Lambda mice motif Mutation neutralization Neutralizing activity offer omicron Omicron variant pangolin Prophylactic PROTECT RBD Receptor binding domain receptor binding domain (RBD) reported sarbecovirus Sarbecoviruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus therapeutic option unique variant variants variants of concern variants of concerns (VOCs). VOCs Wuhan β-sheet
[DOI] 10.1002/smtd.202200387 PMC 바로가기 [Article Type] Article

Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins

SARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역

Article

Published on 2022-06-282022-09-11
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens
[DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

SARS-CoV-2의 뉴클레오캡시드 돌연변이는 복제 및 병인을 증가시킵니다

Article

Published on 2022-06-212022-09-11
Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법,

LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed mice

Article

Published on 2022-06-012022-10-05
Journal: Virologica Sinica [Category] 두창, 비임상, 수두, 진단, 홍역,