Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation ProgramsOriginal Research Published on 2019-07-242023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Bioactivity CD8+ T lymphocytes IL-33 mTOR nutrient deprivation ST2L [DOI] 10.3389/fimmu.2019.01698 PMC 바로가기 [Article Type] Original Research
Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease항염증성 microRNA-146a는 식이 유발 대사 질환으로부터 생쥐를 보호합니다Research Article Published on 2019-02-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence adipose Adipose tissue Adiposity administration blockade blood glucose cellular cellular metabolism cellular respiration chronic inflammation Combination contribute Control controls creating Critical demonstrated develop Diabetic diabetic patient diabetic patients diet dysregulated Evidence expressed expression Factor fat genetics Glucose Glycolysis Human identifying Immune cell immune cells increase in Inflammation inflammatory function inflammatory gene inflammatory genes inflammatory pathways influence inhibitor Interaction investigated involved Macrophage macrophages mechanism metabolic disease metabolic pathway metabolic pathways metabolic processe metabolic processes metabolism mice microRNA miR-146 miRNA mTOR NF-κB NF-κB activation obese obesity pathway phenotype Phenotypes potential therapeutic target Prevent Pro-inflammatory genes PROTECT protective role provide Rapamycin reduced regulate regulated Regulatory represse Research RNA-sequencing shown Symptom tissue tissue macrophage Traf6 weight gain wild-type [DOI] 10.1371/journal.pgen.1007970 PMC 바로가기 [Article Type] Research Article
Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation포유류 Hbs1L 결핍은 Pelota 고갈 및 80S 모노솜 축적과 관련된 선천적 기형 및 발달 지연을 유발합니다Research Article Published on 2019-02-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 4EBP1 accompanied accumulation addition affecting aggregation Anomaly baseline biallelic mutation biallelic mutations binding cause caused Cell cells Characteristics characterized coding region conditions control mechanisms controls Critical deficiency demonstrated Depletion developmental delay downstream Effect Efficiency element expression facial fibroblast fibroblasts functional growth Hbs1L human cell human cells humans hypotonia implicated increase in inhibition involved knockdown lack lead Loss mechanism mice monosome mouse model mRNA mRNA level mTOR mTOR expression murine Mutation ortholog pathway Patient pelo phenotype phenotypic Phosphorylation polysome proteasomal proteasome Protein protein expression Quality control reduced Regulation reported rescued restored resulting ribosomal RNA ribosome ribosomes RNA RT-PCR Sequencing Support the patient These data tissues transcript translation translational upregulation utilization western blot Western blot analyses Western blot analysis yeast [DOI] 10.1371/journal.pgen.1007917 PMC 바로가기 [Article Type] Research Article
Distinct notch signaling expression patterns between nucleoside and nucleotide analogues treatment for hepatitis B virus infectionArticle Published on 2018-06-272023-06-16 Journal: Biochemical and Biophysical Research Communication [Category] B형 간염, [키워드] Hepatitis B virus mTOR Notch signaling nucleos(t)ide analogues [DOI] 10.1016/j.bbrc.2018.04.236
Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?마스터 조절기 mTOR를 목표로 하는 것: 기생충 감염의 신경학적 결과를 예방하기 위한 새로운 접근법?Review Published on 2017-11-212024-08-12 Journal: Parasites & Vectors [Category] 말라리아, [키워드] Adjunctive therapy Cerebral Parasitosis malaria mTOR Neuropathology Protozoa Rapamycin [DOI] 10.1186/s13071-017-2528-3 PMC 바로가기 [Article Type] Review
Interleukin 15: A key cytokine for immunotherapyarticle Published on 2016-10-312024-09-01 Journal: Cytokine & Growth Factor Reviews [Category] 말라리아, [키워드] Autoimmune diseases Interleukin-15 JAK/STAT mTOR [Article Type] article
Sirolimus and metformin synergistically inhibit hepatocellular carcinoma cell proliferation and improve long-term survival in patients with HCC related to hepatitis B virus induced cirrhosis after liver transplantationResearch Paper Published on 2016-09-202023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] HCC Liver transplantation metformin mTOR Rapamycin [DOI] 10.18632/oncotarget.11591 PMC 바로가기 [Article Type] Research Paper
Risk of Infectious Complications in Hemato-Oncological Patients Treated with Kinase InhibitorsReview Published on 2015-04-212024-09-04 Journal: Biomarker Insights [Category] 대상포진, [키워드] BCR signaling BCR-ABL BRAF EGFR infections Infectious complications Jak kinase inhibitors mTOR targeted therapy TKI VEGF [DOI] 10.4137/BMI.S22430 PMC 바로가기 [Article Type] Review
Molecular Networks of Human Muscle Adaptation to Exercise and Age운동과 나이에 대한 인간 근육 적응의 분자 네트워크Research Article Published on 2013-03-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 13q21 1q12 activated all-trans-retinoic acid Activation adaptation age Ageing all-trans-retinoic acid alteration Analysis applicability aryl-hydrocarbon receptor signaling ATRA Author chance chromosomal Cohort cohorts component Compound continuum contributed developmental processe developmental processes Differential analysis displaying DNA topoisomerase down-regulation driven by EET endurance exercise endurance exercise training Epigenetic events exercise exhibited found Gain Gene gene-expression gene-networks gene-set gene-sets generate Genes growth Health care Health care system health care systems Human hypertrophic response hypertrophic responses hypertrophy identify Impact independent individual individuals Ingenuity Pathway Analysis inhibited Interaction IPA lean mass life loci Longevity mimicking molecular molecular network molecular networks mTOR muscle muscle age muscle growth Musculoskeletal network Older overlap pathway phenotype physical activity post-transcriptional processe post-transcriptional processes profile proportion Quality of life Rapamycin reduced referred to regulated related resistance-exercise training RET retinoic acid ribosomal genes rising risk RNA signature RNA signatures rRNAs RXR sarcopenia sarcopenic Serotonin Signaling significantly Society stream subject topoisomerase transcript unique Z-score [DOI] 10.1371/journal.pgen.1003389 PMC 바로가기 [Article Type] Research Article
Rapamycin with Antiretroviral Therapy in AIDS-Associated Kaposi Sarcoma: An AIDS Malignancy Consortium StudyArticle Published on 2011-12-012024-09-04 Journal: Journal of acquired immune deficiency syndromes (1 [Category] 대상포진, [키워드] AIDS Kaposi sarcoma mTOR pharmacokinetic interactions Rapamycin [DOI] 10.1097/QAI.0b013e31823e7884 PMC 바로가기 [Article Type] Article