Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655YIns215KLRS 및 H655Y의 비 RBD 돌연변이에 의한 SARS-CoV-2의 N501Y 부여 마우스 감염성의 장거리 향상Article Published on 2022-06-052022-09-11 Journal: Biology Direct [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 Alpha Beta changes in cooperation Cross-species transmission disrupt ENhance facilitate flexible Gamma H655Y high infectiousness hosts Impact impacts increase Ins215KLRS insertion Interaction intramolecular interaction less Local mice mouse Mouse infection mouse-adapted strain mutant Mutation N-terminal domain N501Y N501Y mutation NTD omicron Omicron variants peptide Protein RBD Receptor binding Receptor-binding domain resulting rodents SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants spike Spike protein suppressed targets the receptor-binding domain variant virus infectivity wild type [DOI] 10.1186/s13062-022-00325-x PMC 바로가기 [Article Type] Article
Persistent viral shedding of severe acute respiratory syndrome coronavirus 2 after treatment with bendamustine and rituximab: A case report벤다무스틴과 리툭시맙 치료 후 중증급성호흡기증후군 코로나바이러스 2의 지속적인 바이러스 배출: 증례 보고Case Reports Published on 2022-06-012022-09-11 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission Bendamustine Case report Chain Reaction Chemotherapy chemotherapy session chronic disease Chronic diseases condition coronavirus coronavirus disease COVID-19 detectable discharged eight FIVE follicular Follicular lymphoma hospital initiated lymphopenia N501Y nasopharyngeal specimen nine NPs on admission Patient patients persistent persistent infection polymerase chain polymerase chain reaction positive receive receiving respiratory rituximab RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tested the patient the SARS-CoV-2 therapy Treatment variant Viral viral shedding [DOI] 10.1016/j.jiac.2022.01.014 PMC 바로가기 [Article Type] Case Reports
The Biological Functions and Clinical Significance of SARS-CoV-2 Variants of CorcernReview Published on 2022-05-202022-10-06 Journal: Front Med (Lausanne) [Category] 진단, [키워드] ACE2 acute respiratory syndrome Affect Alpha variant Angiotensin-converting enzyme antigenic B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biological blunt Brazil Characteristics clinical Combination convalescent individuals coronavirus country COVID-19 COVID-19 vaccines Deleterious Deletion Delta delta variant E484K E484K mutation Efficacy ENhance evade FIVE function Gamma Genetic immune evasion India Infection influence immune response insertion K417 Mutation mutations N501Y Neutral Neutralizing antibodies neutralizing antibody omicron optimism other variant P.1 pathogenicity phenotype promote raise RBD Receptor binding domain Region Reinfection risk SARS-CoV-2 SARS-CoV-2 variant sensitivity severe disease Significance South Africa Spike protein Spread spread to Strains the Alpha variant the Beta variant the Delta variant the Gamma variant the Omicron variant the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein the United State The United States Transmissibility triggered United Kingdom vaccination Vaccine-induced immunity Vaccines variant variant of concern variants of concern viral cell viral replication Virological virus VoC VOCs [DOI] 10.3389/fmed.2022.849217 PMC 바로가기 [Article Type] Review
Evaluation of a Rapid and Accessible Reverse Transcription-Quantitative PCR Approach for SARS-CoV-2 Variant of Concern Identification관심 식별의 SARS-CoV-2 변이체에 대한 신속하고 접근 가능한 역전사-정량적 PCR 접근 방식의 평가Article Published on 2022-05-182022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha amplification approach assist Beta Clinical prognosis clinical settings collected complementary concern coronavirus COVID-19 Delta demonstrated E484K epidemiological epidemiological surveillance Gamma Genetic identification infections K417N L452R Laboratory Local multiplex Mutation N501Y nucleic acid nucleic acid amplification nucleic acid amplification tests omicron PCR quantitative PCR Rapid reaction response RT-qPCR SARS-CoV-2 SARS-CoV-2 nucleic acid Sequencing severe acute respiratory syndrome Coronavirus Spike protein Surveillance swab sample T478K therapy Transmissibility upper respiratory tract vaccination validation variant variants of concern VOCs WGS whole-genome sequencing [DOI] 10.1128/jcm.00178-22 PMC 바로가기 [Article Type] Article
Rapid and Accurate Identification of SARS-CoV-2 Variants Using Real Time PCR AssaysReal Time PCR 어세이를 사용한 SARS-CoV-2 변이체의 빠르고 정확한 식별Article Published on 2022-05-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Alpha B.1.1.7 B.1.351 B.1.617.2 Beta blinded Combination correlated COVID-19 COVID-19 pandemic Delta delta variant Diagnosis diagnostic testing disease severity E484K effort Epidemiology evade Gamma Genomic surveillance genotyping help host immunity identification Laboratory lack Lineage management Mutation N501Y omicron P.1 P681R Patient Patient management PCR positive primer Rapid real-time RT-PCR resource reverse transcription-PCR routine diagnostic testing RT-PCR S982A SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants screened Sequencing specimen specimens spike gene Surveillance susceptibility tested the SARS-CoV-2 Therapeutics These data time Transmissibility variant variants Viral variants WGS while whole-genome sequencing [DOI] 10.3389/fcimb.2022.894613 PMC 바로가기 [Article Type] Article
Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant오미크론 변이체에서 스파이크 단백질의 수용체 결합 도메인과 인간 안지오텐신 전환 효소-2 간의 결합 상호작용Article Published on 2022-05-052022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Affect angiotensin Antibody neutralization bind conformational changes contagious COVID-19 pandemic decrease distribution electrostatic interactions exacerbated Human K417N molecular molecular dynamics Mutation mutations N501Y new SARS-CoV-2 omicron Other predicted RBD RBD mutation Receptor-binding domain resulting S-protein spike Spike protein Strains systematic analysis T478K the receptor-binding domain the spike protein Transmissibility variant [DOI] 10.1021/acs.jpclett.2c00423 PMC 바로가기 [Article Type] Article
Potential inhibitor for blocking binding between ACE2 and SARS-CoV-2 spike protein with mutations돌연변이가 있는 ACE2와 SARS-CoV-2 스파이크 단백질 간의 결합을 차단하는 잠재적 억제제Article Published on 2022-05-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] (+)-Catechin (Pubchem CID: 9064) ACE2 addition binding catechin coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic death E484K GB-1 glycyrrhizic acid Glycyrrhizic acid (Pubchem CID: 14982) Health Organization high mutation rates Infection inhibit inhibited inhibitor K417N K417N mutation L452R Mutation Mutation rates N501Y outbreak pandemic Potential Prophylaxis Protein RBD Receptor binding domain reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein several variant several variants single mutation spike Spike protein T478K Temple Tian variants of SARS-CoV-2 World Health Organization writing Wuhan Wuhan, China [DOI] 10.1016/j.biopha.2022.112802 PMC 바로가기 [Article Type] Article
Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variantsSARS-CoV-2 스파이크 항원으로 과면역된 트랜스염색체 소의 인간 면역글로불린은 바이러스 변이체를 효율적으로 중화합니다Article Published on 2022-04-292022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus amino-acid anti-SARS-CoV-2 anti-SARS-CoV-2 immunoglobulin bovine convalescent coronavirus COVID-19 Deletion deletions DNA dose E484K effective Effectiveness followed by Human human immunoglobulin Human plasma Immunity immunization Immunoglobulin in vitro inhibit insect cells mAb mAbs monoclonal antibodies monoclonal antibody mutant N501Y neutralization neutralization potency neutralize Plasmid plasmid DNA polyclonal polyclonal antibodies produced purified reduce repeated respiratory resulting retained S gene S protein S variant S477N SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike antigen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein stomatitis Substitution substitutions the SARS-CoV-2 therapeutic transchromosomic bovines Vaccines variant variants variants of concern vesicular stomatitis vesicular stomatitis virus viral variant VSV Wuhan strain [DOI] 10.1080/21645515.2021.1940652 PMC 바로가기 [Article Type] Article
Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron MutationsSARS-CoV-2 스파이크 변이체 복합체와 숙주 수용체의 결합 및 알로스테릭 상호작용에 대한 컴퓨터 시뮬레이션 및 네트워크 기반 프로파일링: 델타 및 오미크론 돌연변이의 기계적 효과 분석Article Published on 2022-04-152022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 complexes ACE2 host receptor allosteric communications analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding binding energetics binding energy binding interaction Community Community network complexes computer constellation contribute Critical Delta Effect energetics Epitopes escape mutants examined functional generate Host host receptor hotspot identify immune evasion integrity Interaction interactions Local MD simulation modulate molecular molecular dynamics Mutation mutational scanning N501Y network analysis omicron Omicron variants plasticity Profiling RBD-ACE2 residue responsible S protein S-RBD SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spike protein sensitivity signal transmission. Simulation spike Spike protein the RBD the SARS-CoV-2 Transmissibility Transmission variant variants virus [DOI] 10.3390/ijms23084376 PMC 바로가기 [Article Type] Article
mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2mRNA-1273 및 Ad26.COV2.S 백신은 SARS-CoV-2의 B.1.621 변이체로부터 보호합니다.Clinical and Translational Article Published on 2022-04-152022-09-14 Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] in vivo vaccine efficacy studies Abstract ACE2 acute respiratory syndrome Ad26.COV2.S Ad26.COV2.S vaccine adenoviral-vectored vaccine AMED animal models B.1.621 center Context coronavirus D614G D950N development disease E484K Efficacy evaluated finding funding greater transmissibility hamster hamsters High dose Immunity immunization induce Infectious disease Infrastructure Innovation Japan Johnson & Johnson Lung infection Lung pathology mice Moderna mRNA vaccine mouse mRNA-1273 mRNA-1273 vaccine N501Y Neutralizing antibodies neutralizing antibody New NIAID NIH omicron P681H Program PROTECT reduced response SARS-CoV-2 SARS-CoV-2 strain Serum neutralizing antibody spike mutation supported Syrian hamster transgenic mice Vaccine variant variant of SARS-CoV-2 variants of SARS-CoV-2 viral variant virus WA1/2020 weight loss [DOI] 10.1016/j.medj.2022.03.009 PMC 바로가기 [Article Type] Clinical and Translational Article