A SARS-CoV-2 nanobody that can bind to the RBD region may be used for treatment in COVID-19 in animalsRBD 영역에 결합할 수 있는 SARS-CoV-2 나노바디는 동물의 COVID-19 치료에 사용될 수 있습니다Article Published on 2022-07-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] animals binding caused cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease in vitro in vivo infecting Infectious virus microorganism microorganisms nanobodies nanobody neutralizing antibody Prevent pseudovirus pseudoviruses RBD RBD protein respiratory S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Spike RBD protein Severe acute respiratory syndrome spike the RBD the SARS-CoV-2 therapeutic effects therapeutic potential Treatment treatment of COVID-19 was obtained was used [DOI] 10.1016/j.rvsc.2022.02.003 PMC 바로가기 [Article Type] Article
Superimmunity by pan-sarbecovirus nanobodies범사르베코바이러스 나노바디에 의한 초면역Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activities against SARS-CoV best booster breadth broadly neutralizing nanobody camelid clade conserved correlated CP: Immunology distance domain effective epitope Epitopes Evolution facilitate FIVE flat flexible Immunity immunized immunology Infection inhalable bispecific nanobody PiN-31 mechanism median milliliter nanobody neutralization potency Neutralizing observé omicron pan-sarbecovirus neutralization proteomics RBD RBD surface Receptor binding residues sarbecovirus SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 variants super immunity. the SARS-CoV-2 V(H)H antibody [DOI] 10.1016/j.celrep.2022.111004 PMC 바로가기 [Article Type] Article
[Expression of a SARS-CoV-2 neutralizing nanobody in Trichoderma reesei]Article Published on 2022-06-252023-07-09 Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Category] COVID19(2023년), [키워드] nanobody Recombinant expression SARS-CoV-2 Trichoderma reesei [DOI] 10.13345/j.cjb.210681
Antibody-nanobody combination increases their neutralizing activity against SARS-CoV-2 and nanobody H11-H4 is effective against Alpha, Kappa and Delta variants항체-나노바디 조합은 SARS-CoV-2에 대한 중화 활성을 증가시키고 나노바디 H11-H4는 알파, 카파 및 델타 변이체에 대해 효과적입니다.Article Published on 2022-06-112022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibodies antibody association Beta binding binding affinity combating Combination complex COVID-19 CR3022 delta variant Delta variants effective electrostatic interaction elicited experiment Gamma H11-H4 health system IMPROVE increase Interaction investigated Lambda llama molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular mechanism molecular mechanisms nanobodies nanobody Neutralizing Neutralizing activity observation predict RBD recent Receptor binding domain reduce SARS-CoV-2 SARS-CoV-2 spike protein significantly Spike protein spread of COVID-19 the binding affinity the SARS-CoV-2 the spike protein Treatment Vaccine van der Waal variant variants of SARS-CoV-2 while [DOI] 10.1038/s41598-022-14263-1 PMC 바로가기 [Article Type] Article
Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants다양한 SARS-CoV-2 변이체의 검출을 위한 뉴클레오캡시드 특이적 진단Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] assays conserved COVID-19 pandemic CR3022 described detect detection diagnostics immune immunoassays immunofluorescence immunoplaque assay mutability Mutation N-terminal domain nanobody nucleocapsid Omicron variant Omicron variants Receptor binding S309 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Specific specific antibodies spike glycoprotein spike-specific antibodies Spike-specific antibody targets Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.926262 PMC 바로가기 [Article Type] Article
Nanobody-based label-free photoelectrochemical immunoassay for highly sensitive detection of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 고감도 검출을 위한 나노바디 기반 무표지 광전기화학 면역분석Article Published on 2022-06-082022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody caused COVID-19 COVID-19 epidemic determine Donor electron donor immunoassay Interaction limit of detection linear nanobody Pathogens photoelectric Photoelectrochemical plasma platform Protein provide public health Resonance effect SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 viral specific biomarkers spike Spike protein steric hindrance [DOI] 10.1016/j.aca.2022.339904 PMC 바로가기 [Article Type] Article
Production and Purification of Shark and Camel Single-Domain Antibodies from Bacterial and Mammalian Cell Expression SystemsArticle Published on 2022-06-012023-07-09 Journal: Current protocols [Category] COVID19(2023년), [키워드] camel VHH nanobody Polymyxin B shark VNAR signal peptide single-domain antibody [DOI] 10.1002/cpz1.459
SARS-CoV-2 detection using a nanobody-functionalized voltammetric device Research Published on 2022-05-232022-10-05 Journal: Communications Medicine [Category] 변종, 진단, 치료기술, [키워드] changes in clinical samples complex coronavirus strain COVID-19 pandemic delta variant detect diagnostic Effects human saliva Infection llama media mutant Mutation nanobody Nasopharyngeal swab non-infected platform point-of-care positive powerful tool provide RBD Receptor binding domain Result RT-qPCR Saliva SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 viral particle sensitivity specificity Spike protein tested the spike protein virus viruses [DOI] 10.1038/s43856-022-00113-8 [Article Type] Research
SARS-CoV-2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking EffectivitySARS-CoV-2 Delta 변이체, 나노바디 결합 및 ACE2 차단 효과 감소Article Published on 2022-05-232022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] absence ACE2 AFM all-atom molecular dynamics simulations angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody atomic bind blocking comparable decrease Delta delta variant domain effective Effectiveness experiment H11-H4 host cells hydrophobic hydrophobic interaction hydrophobic interactions inhibit Interaction investigated less Microscopy molecular molecular dynamics Molecular dynamics simulation molecular dynamics simulations Mutation nanobodies nanobody neutralize overlapping Prevent RBD RBD binding receptor Receptor-binding domain rupture Salt Bridge SARS-CoV-2 side spike glycoprotein Spread the receptor-binding domain variant variants of SARS-CoV-2 viral infection [DOI] 10.1021/acs.jcim.1c01523 PMC 바로가기 [Article Type] Article
A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate BindingSARS-CoV-2의 스파이크 수용체 결합 도메인과 친밀한 결합의 구조적 기초를 표적으로 하는 강력한 중화 나노바디Article Published on 2022-05-182022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Basis binding binding affinity binding site biochemical analyses characterization competing complex coronavirus delta variant Diseases domain drug candidates engage epitope In-vitro increase nanobodies nanobody neutralization neutralization activity Neutralizing overlapping potent Potential treatment raised receptor related diseases respiratory reveal S-RBD SARS-CoV-2 SARS-CoV-2 S severe acute respiratory syndrome Coronavirus spike receptor-binding domain Spread structural basis target targeting the Spike These data Viral viral spike virus [DOI] 10.3389/fimmu.2022.820336 PMC 바로가기 [Article Type] Article