Translating known drivers of COVID-19 disease severity to design better SARS-CoV-2 vaccines더 나은 SARS-CoV-2 백신을 설계하기 위해 COVID-19 질병 중증도의 알려진 동인을 번역Review Published on 2022-02-012022-09-11 Journal: Current opinion in virology [Category] COVID19(2023년), SARS, 변종, [키워드] antiviral signaling approach Clinical outcome COVID-19 disease severity disease driver effective Effective current Efficacy Evidence Health policy human population identifying immune IMPROVE Improving Infection Infectious disease initial Lung inflammation mechanism natural immunity platform Prevent provide public health question researcher SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 vaccine Spread Vaccine vaccine platform Vaccines viral clearance viral variant [DOI] 10.1016/j.coviro.2021.11.012 PMC 바로가기 [Article Type] Review
Investigating vaccine-induced immunity and its effect in mitigating SARS-CoV-2 epidemics in China백신 유발 면역 및 중국에서 SARS-COV-2 전염병을 완화시키는 데 영향을 미치는 결과 조사Research Article Published on 2022-01-312022-09-10 Journal: BMC Medicine [Category] SARS, 변종, [키워드] age China Chinese compartmental model country Coverage COVID-19 delta variant develop Efficacy Epidemic Epidemics estimate herd immunity Immunity Infection initiated lack mitigate natural immunity natural infection provided reached reduce Result return SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 transmission severe disease SLIR model supplementary material tested the vaccine the vaccines Transmission unlikely vaccination Vaccination program Vaccine vaccine efficacy Vaccine-induced immunity [DOI] 10.1186/s12916-022-02243-1 PMC 바로가기 [Article Type] Research Article
A Continuous Markov-Chain Model for the Simulation of COVID-19 Epidemic DynamicsArticle Published on 2022-01-262022-10-28 Journal: Biology [Category] COVID-19, [키워드] addition antibodies applied approach basic reproduction number Characteristics Contact Continuous Coverage COVID-19 COVID-19 epidemic demonstrated distribution Dynamics Effect Epidemic Evidence explain Factor Frequency Guidance Herd immunity threshold hotspot Human Immunity indicate individual Infection Markov-chain model Misconception Model Mutation natural immunity predict predicted Probability Reproduction number SARS-CoV-2 significantly significantly higher simple Simulation Spread spread of COVID-19 statistical Support Taking tested the epidemic threshold vaccination Variation virus [DOI] 10.3390/biology11020190 PMC 바로가기 [Article Type] Article
An update of anti-viral treatment of COVID-19COVID-19의 항바이러스 치료 업데이트Review Published on 2021-12-172022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료제, [키워드] ACE-2 Administered Anti-viral treatment Antiviral AT-527 biological processe biological processes bromhexine camostat clinical trial clinical trials convalescent plasma COVID-19 drug dutasteride early phase effective effective antiviral treatment evaluated Favipiravir fluvoxamine group Host host protein host proteins human cell Hydroxychloroquine include inhibitor inhibitors interfere interferons Ivermectin knowledge Laboratory lactoferrin Lopinavir Lopinavir/ritonavir merimepodib molnupiravir moment monoclonal antibodies monoclonal antibody nanobodies natural immunity niclosamide nitazoxanide pandemic PF-07304814 PF-07321332 Plitidepsin protease Protein Proteins proxalutamide PTC299 RCTs Remdesivir Result Ritonavir RNA SARS-CoV-2 subject Support target protein target proteins the disease to define Treatment treatment for COVID-19 treatment of COVID-19 Trial umifenovir Viral viral entry Viral RNA virus [DOI] 10.3906/sag-2106-250 PMC 바로가기 [Article Type] Review
Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study카타르의 SARS-COV-2 B.1.1.7 변형 및 재감염의 소개 및 확장 : 전국 대표 코호트 연구Research Article Published on 2021-12-162022-09-10 Journal: PLoS Medicine [Category] SARS, 변종, [키워드] 95% CI Alpha antibody antibody-positive result B.1.1.7 B.1.1.7 variant circulating variants Cohort cohort study commenced consequence Efficacy Epidemic epidemic wave Epidemiology expansion First wave immune evasion incidence individual individuals Infection introduced investigated mathematical naïve National natural immunity natural infection occurred other variants PCR-confirmed public health Reinfection Research researcher retrospective cohort SARS-CoV-2 variant second wave statistical analysis sudden the SARS-CoV-2 triggering United Kingdom variant variants wild-type wild-type SARS-CoV-2 [DOI] 10.1371/journal.pmed.1003879 PMC 바로가기 [Article Type] Research Article
A Systematic Review of the Protective Effect of Prior SARS-CoV-2 Infection on Repeat Infection반복 감염에 대한 이전 SARS-CoV-2 감염의 보호 효과에 대한 체계적인 검토Article Published on 2021-12-012022-09-11 Journal: Evaluation & the health professions [Category] SARS, 변종, [키워드] Analysis average risk baseline Case report Case series Chain Reaction Cohort Cohort studies cohorts conducted control groups COVID COVID-19 criteria determined by Effect eligible estimate excluded Follow-up human participants identify Immunity individuals infected with SARS-CoV-2 Infection information medRxiv natural immunity outcome participant PCR polymerase chain polymerase chain reaction Prior infection protection protective effect Re-infection reduction Reinfection Repeat Research retrieved review risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants searched Standard deviation systematic analysis systematic review uninfected vaccination Vaccine was used were excluded [DOI] 10.1177/01632787211047932 PMC 바로가기 [Article Type] Article
Knowledge and Attitudes Toward Covid-19 and Vaccines Among a New York Haredi-Orthodox Jewish Community뉴욕 Haredi-Orthodox 유대교 공동체의 Covid-19 및 백신에 대한 지식과 태도Observational Study Published on 2021-12-012022-09-11 Journal: Journal of community health [Category] SARS, 변종, 임상, [키워드] 95% CI 95% confidence interval adjusted odds ratio Antibody test Attitude Brooklyn Community conducted COVID-19 COVID-19 pandemic COVID-19 vaccine cross-sectional difficulty examined group Health health information Immunity impacted independent predictors individual Infection information morbidity morbidity and mortality naïve individuals natural immunity natural infection New York observational study organizations Orthodox Jewish pandemic paper participant path physician Physicians positive predictor provide public health question reported Research respond risk SARS-CoV-2 viral subpopulations survey Transmission Trust unique vaccination Vaccine Vaccine hesitancy Vaccines variants [DOI] 10.1007/s10900-021-00995-0 PMC 바로가기 [Article Type] Observational Study
A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trialResearch article Published on 2021-12-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 유전자 메커니즘, 임상, [키워드] adverse event Anti-RBD antibody Antibody titre Asymptomatic baseline booster cellular response clinical clinical trial convalescent COVID-19 Cuba dimeric elicited ELISA ENhance Environment evaluated finding funding greater Humoral response IFN-γ IgG increase in individual inhibitory Intramuscular injection Local median Mild minor natural immunity neutralization Open-label Partial Participants PCR-positive Primary outcome producing Public reactogenicity Receptor binding domain registry Reinfection reported safety profile SARS-CoV-2 Science secondary outcome Serious Adverse Event single dose subclinical infection T cell technology TNF-α vaccination Vaccine vaccine immunogenicity Virus neutralization titre [DOI] 10.1016/j.lana.2021.100079 [Article Type] Research article
Rapid relaxation of pandemic restrictions after vaccine rollout favors growth of SARS-CoV-2 variants: A model-based analysis백신 롤아웃 후 전염병 제한의 급속한 이완은 SARS-COV-2 변이체의 성장을 선호합니다 : 모델 기반 분석Research Article Published on 2021-11-242022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, [키워드] Analysis condition conditions COVID-19 effective Efficacy favor feasible growth matter morbidity Mortality natural immunity occur pandemic Public health intervention Rapid reduced Region return SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 vaccine situation suppress suppression susceptibility the United State the vaccine the vaccines Transmission United States utility vaccinal Vaccine Vaccines variant variants variants of SARS-CoV-2 Viral viral variant Viral variants [DOI] 10.1371/journal.pone.0258997 PMC 바로가기 [Article Type] Research Article
Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization AssaysSARS-CoV-2에 대한 체액 면역 평가: 플라크 감소 중화 테스트 및 기존 및 대리 중화 분석의 다중 실험실 비교 검증Research Article Published on 2021-11-172022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, [키워드] addition antibody antibody tests approval assays characterized conducted Conventional COVID-19 COVID-19 vaccines death demonstrated ELISA ENhance enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluate Evaluating flow cytometry Health Organization human ACE2 human ACE2 receptor humoral Humoral immunity immune responses Immunity immunoserology include laboratory-confirmed Laboratory-confirmed COVID-19 lentiviral luciferase multitude natural immunity neutralization neutralization test neutralization tests Neutralizing Neutralizing antibodies Neutralizing antibody response offer outlined Patient plaque-reduction neutralization test platform Precision PRNT Protective protective immune response protective immunity pseudotype quantification reference standard SARS-CoV-2 SARS-CoV-2 PRNT SARS-CoV-2-neutralizing antibodies serological Serological assay specificity specimen surrogate Test Vaccine validation World Health Organization [DOI] 10.1128/Spectrum.00886-21 PMC 바로가기 [Article Type] Research Article