mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 InfectionmRNA-lncRNA 공동 발현 네트워크 분석, 심각한 SARS-CoV-2 감염 시 면역 기능 장애에서 lncRNA의 역할 밝혀Article Published on 2021-03-032022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] Activation addition affected analyzed anti-viral response anti-viral responses BALF Bronchoalveolar lavage fluid Clinical features co-expression network co-expression network analysis correlated COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients critical COVID-19 patients cytokine cytokine signaling Cytokine storm Cytokine storms Cytokines differentially expressed epithelial cell epithelial cell line expression Factor global public health Host human lung human lung epithelial cell lines hyper-inflammatory response Hyper-inflammatory responses immune response immune responses Infection involved lncRNA long non-coding RNA Lungs molecular interaction molecular mechanism network neutrophilia non-coding RNA pathway Patient patients plasma pro-inflammatory cytokine pro-inflammatory cytokines required respiratory respiratory disorder responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 virus Sepsis Sequencing severe SARS severe SARS-CoV-2 specimen the cytokine storm Transcriptome transcriptome sequencing with COVID-19 [DOI] 10.3390/v13030402 PMC 바로가기 [Article Type] Article
MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2Article Published on 2021-02-182022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] affected bind binding candidate COVID-19 Diseases distribution drug effective Gene Expression H19 human miRNAs in viral Infection inflammatory complications inhibiting leader sequence lncRNA Long long non-coding RNA microRNA motif non-coding RNA Non-coding RNAs nucleotide oligosequences Potential promote promoted pulmonary arterial hypertension Respiratory system RNA SARS-CoV-2 SARS-CoV-2 genome selective sequence Specific spike target target therapy the SARS-CoV-2 genome therapy transcript Vaccine viral genome viral infections Viral RNA viral-induced [DOI] 10.3390/ncrna7010014 PMC 바로가기 [Article Type] Article
Honeysuckle Aqueous Extracts Induced let-7a Suppress EV71 Replication and Pathogenesis In Vitro and In Vivo and Is Predicted to Inhibit SARS-CoV-2Article Published on 2021-02-162022-10-28 Journal: Viruses [Category] COVID-19, [키워드] let-7a accompanied aqueous attenuate cell line cells Chinese demonstrated dengue virus endogenous EV71 Evidence examined expressed expression Extract honeysuckle Human in vitro in vivo indicate induce induced ingestion innate response inoculated investigated Lonicera japonica luciferase activity luciferase reporter plasmid mice miRNA miRNA expression miRNAs non-coding RNA overexpressed overlapped pathogen invasion Pathogenesis Plaque assay predicted Prevent profile protein expression Real-time PCR Replication reporter RNA RNA genome RT-PCR SARS-CoV-2 sequence suppress suppressive function survival TCM upregulated upregulation Viral load viral replication Viral RNA virus replication virus titer western blotting [DOI] 10.3390/v13020308 PMC 바로가기 [Article Type] Article
miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial CellsArticle Published on 2021-02-022022-10-30 Journal: Non-Coding RNA [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome AKT Angiogenesis approaches blood–brain barrier Brain cause CD304 cell line cellular coronavirus coronavirus disease COVID-19 Endothelial cell Endothelium epigenetics Evidence functional hBMEC Human Immunity implicated in vitro microRNA miR-24 miR-24-3p NEUROLOGY Neuropilin-1 non-coding RNA NRP1 recent Regulation SARS-CoV-2 shown target Transcription transmembrane glycoprotein vascular permeability VEGF VEGF165R [DOI] 10.3390/ncrna7010009 PMC 바로가기 [Article Type] Article
Identification and analysis of long non-coding RNAs and mRNAs in chicken macrophages infected with avian infectious bronchitis coronavirusResearch Article Published on 2021-01-202022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] addition Affect amino acid metabolism Analysis bronchitis cells cellular chicken competing coronavirus cultured cell differentially expressed down-regulated expression profile Factor Gga-miR-30d HD11 Host IBV IBV infection identification indicated Infectious Bronchitis Virus Innate immunity involved lncRNA Long long non-coding RNA Macrophage miR-146a-5p mRNA mRNAs non-coding RNA nucleic acid metabolism nucleotides Ontology Pathogenesis pathway enrichment provided Result RNA Sequencing subset supplementary material uninfected cells up-regulated viral infections [DOI] 10.1186/s12864-020-07359-3 PMC 바로가기 [Article Type] Research Article
rfaRm: An R client-side interface to facilitate the analysis of the Rfam database of RNA familiesResearch Article Published on 2021-01-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis database demonstrated elements example facilitate feature genomic information non-coding RNA R package Rfam RNA secondary structure sequence the SARS-CoV-2 genome [DOI] 10.1371/journal.pone.0245280 PMC 바로가기 [Article Type] Research Article
Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19Bioengineering and Biotechnology Published on 2021-01-152022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] activated acute respiratory distress Alpha Alter Analysis ARDS Betacoronavirus candidate caused cellular processes conserved COVID-19 COVID-19 cytokine storm cytokine Cytokine storm Cytokines disease DNA damage FIVE functions Gene Expression Genes Genetic humans identify in vitro in vivo infect inflammatory immune response lncRNA Long marker markers MERS-CoV new strain non-coding RNA NorAD outbreak overexpressed Regulation regulatory element RNA SARS-CoV SARS-CoV-2 storm syndrome targets the disease virus Wuhan, China [DOI] 10.3389/fbioe.2020.582953 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
RNAcentral 2021: secondary structure integration, improved sequence search and new member databasesAcademicSubjects/SCI00010 Published on 2021-01-082022-10-31 Journal: Nucleic Acids Research [Category] Coronavirus, [키워드] Community database faster include information miRbase ncRNA non-coding RNA organism provide resource Rfam RNA RNAs secondary structure sequence sequence similarity Subtypes [DOI] 10.1093/nar/gkaa921 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Novel modulators of p53-signaling encoded by unknown genes of emerging virusesResearch Article Published on 2021-01-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] approach binding Cancer Cell de novo DNA Ebola experiment function functional functions genomic Hypothesis hypothetical identify infections Influenza Interaction interfere long non-coding RNA mechanism molecular New non-coding RNA novel Open reading frame p53 predicted Protein resource RNA viruses RNAs Signaling Systems biology tested transcription factor viral nucleic acid Viral protein Viral proteins virus viruses Zika Zika virus ZIKV [DOI] 10.1371/journal.ppat.1009033 PMC 바로가기 [Article Type] Research Article
SARS-Cov-2 Interactome with Human Ghost Proteome: A Neglected World Encompassing a Wealth of Biological DataCommunication Published on 2020-12-192022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] addition Affinity purification alternative ORF alternative protein anti-viral response Biological cellular co-immunoprecipitation co-IP COVID-19 outbreak database DMPK Drug repurposing eukaryotic Evidence function functional Ghost ghost protein host cell Human identify initial innate immune response Interaction interactions interactome interactomics involved metabolism missing mRNA ncRNAs Neglected non-coding RNA OpenProt ORF Perspective pharmacokinetic physiological predicted Protein proteome proteomics responsible SARS-CoV-2 target the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic strategies therapeutic targets Therapies thought translated translation Viral protein Viral proteins [DOI] 10.3390/microorganisms8122036 PMC 바로가기 [Article Type] Communication