Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques면역 정보학 및 구조 기반 약물 발견 기술을 사용하여 잠재적 치료제를 위한 SARS-CoV2 뉴클레오캡시드 단백질 표적화Article Published on 2020-12-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, 치료제, [키워드] Analysis antigens approach B-cell B-cell epitope B-cell epitopes bioinformatics candidate complex coronavirus Coverage COVID-19 Critical docking Drug discovery epitope Epitope-based vaccine Epitopes help identify IFN-γ Immunity Immuno-informatics induce inhibitor leucocyte life cycle molecular dynamics Molecular dynamics simulation N protein N-protein N-terminal domain non-allergenic non-toxic nucleocapsid nucleocapsid protein Occurrence Protein ribonucleoprotein SARS-CoV2 SARS-CoV2 infection sequence Stage Structure T-cell epitope T-cell epitopes targeting the N protein therapeutic intervention therapeutic interventions therapeutic option therapeutic options Vaccine Viral viral genome viral life cycle zidovudine zidovudine triphosphate [DOI] 10.1016/j.biopha.2020.110914 PMC 바로가기 [Article Type] Article
Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2Article Published on 2020-11-302022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 3D structure activating approach B-cell binding complex Computational models Coronavirus disease 2019 COVID-19 cytokine disease docking effective epitope Free energy calculation high affinity highest Human immune system immune response immunogenic immunoinformatics in vivo initial linkers Molecular dynamics simulation Molecular modelling Multi-epitope vaccine non-allergenic non-toxic peptide Potential Precaution Prophylactic Protein vaccines Safe SARS-CoV-2 Side effects Spread structural proteins subunit suggested T-cell the vaccine Toll-like receptor 3 Vaccine viral infection virus [DOI] 10.1038/s41598-020-77547-4 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Inhibition by Sulfonated CompoundsCommunication Published on 2020-11-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 Antiviral attachment inhibitor binding Cell cellular entry Compound coronavirus demonstrated enzyme group heparan sulfates inhibition inhibitory activity Interaction investigated mechanism non-toxic Prevent receptor reduced SARS-CoV-2 SARS-CoV2 shown Spike protein sulfated sulfonated these compound Treatment vesicular stomatitis virus virucidal virus viruses [DOI] 10.3390/microorganisms8121894 PMC 바로가기 [Article Type] Communication
The Need for Ocular Protection for Health Care Workers During SARS-CoV-2 Outbreak and a Hypothesis for a Potential Personal Protective EquipmentSARS-CoV-2 발병 시 의료 종사자를 위한 안구 보호의 필요성 및 잠재적 개인 보호 장비에 대한 가설Public Health Published on 2020-11-122022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, [키워드] Academy anti-viral activity Appropriate Asymptomatic carriers broad spectrum caused Clinical practice clinics Concentration conformation Contact contact lens Contamination coronavirus Critical droplet effective entry receptor equipment eye surgery Goggles griffithsin Health care Health care worker health care workers health system health systems high risk high risk patients higher risk infected with SARS-CoV-2 inhibit interfere majority mandatory manifestation medical staffs moderate moderate to severe non-toxic ocular ocular protection ophthalmology organization organizations outbreak Patient patients Personal protective equipment Physical examination positive Potential Practitioner protection Protective reduce reported risk of infection SARS-CoV SARS-CoV-2 shown Side effects Spike protein Spike proteins surgery sustained releasing contact lens transmission of SARS-CoV-2 Viral Viral RNA viruses vision water WHO worker [DOI] 10.3389/fpubh.2020.599757 PMC 바로가기 [Article Type] Public Health