Qualitative and Quantitative Analysis of Ukrainian Iris Species: A Fresh Look on Their Antioxidant Content and Biological ActivitiesArticle Published on 2020-10-082022-10-30 Journal: Molecules [Category] Coronavirus, MERS, [키워드] Iris rhizomes 229E activity Analysis analyzed anti-allergic Anti-inflammatory anti-inflammatory activity antioxidant Biological caffeic acid Cancer cells Compound compounds content coronavirus 229E cytotoxic cytotoxic effect demonstrated evaluated examined exhibited expression Fresh gallic acid group highest HPLC-ABTS HPLC-DAD human neutrophils IRIS Iris sibirica limit marker methanol Nrf2 Phenolic compounds Qualitative quantification Quantitative standard reference UPLC–MS/MS [DOI] 10.3390/molecules25194588 PMC 바로가기 [Article Type] Article
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarateArticle Published on 2020-10-022022-10-04 Journal: Nature Communications [Category] MERS, SARS, 신약개발, 진단, 치료제, [키워드] addition agonist agonists airway anti-inflammatory activity antioxidant Antiviral antiviral activity approved biopsy cell lines cellular clinically consequence coronavirus 2 COVID-19 COVID-19 pathology COVID-19 patients cytopathogenic effect decrease disease effective fumarate Gene Expression Herpe host inflammatory response immunology induce Infection Inflammatory responses inhibit inhibitory effect limit mechanism Microbiology Nrf2 pathogenic pathogenic virus pathogenic viruses pathway pro-inflammatory response Replication required respiratory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection suppressed type I interferon vaccinia virus virus replication Zika virus [DOI] 10.1038/s41467-020-18764-3 PMC 바로가기 [Article Type] Article
Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection SeverityHypothesis Published on 2020-07-242022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE2 ACE2 receptors activate Activation acute respiratory syndrome age angiotensin-converting enzyme 2 antioxidant Antiviral Cell conditions coronavirus COVID-19 decrease disease pathogenesis downregulating EGCG ENhance expression Factor flavonoid flavonoids Genes high affinity Hypothesis immune response increase infections Inflammation inflammatory process Innate immunity modulate modulated Nrf2 obesity oxidative stress pathway Prevent prevention priming PROTECT Proteins receptor reduce reducing respiratory epithelial cells respiratory viral infections ROS SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severity spike glycoprotein thymoquinone transcription factor viral entry viral infection viral life cycle Vitamin D3 [DOI] 10.3390/antiox9080659 PMC 바로가기 [Article Type] Hypothesis
Nrf2 Activator PB125 ® as a Potential Therapeutic Agent against COVID-19Article Published on 2020-06-122022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] “cytokine storm” HDAC5 ACE2 activate Activation activator Adhesion Molecule affecting age agent ALI Antiviral assays Cell cellular chronic inflammation coronavirus COVID-19 CXCL10 cytokine Cytokine storm Cytokines Decline decrease Diseases downregulate downregulation E-selectin endothelial cells Evidence examined expression gene expression level GeneChip Genes genes encoding HepG2 cells host cells ICAM-1 IL-6 Immunity include Inflammation intensity involved LIF mechanism Microarray mRNA expression NFE2L2 Nrf2 oxidative Potential regulate Replication RNA-Seq SARS-CoV-2 SARS-CoV-2 entry significantly surface receptor susceptibility susceptible the spike protein TMPRSS2 TNF-α transcription factor type 2 diabetes VCAM-1 viral infections [DOI] 10.3390/antiox9060518 PMC 바로가기 [Article Type] Article
Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating FactorsReview Published on 2020-06-102022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] accompanied activated Activation adopted Affect AMPK B cells Biomarker Cancer cardiovascular disease change chronic Chronic low-grade inflammation Combination Community complex Context COVID-19 COX2 demonstrated diabetes diet dietary dietary habit Diseases dose driven by Epidemics Factor fasting fatty acids fiber FoxO Health healthcare help hospitals Human IKK IMPROVE individual individual level Inflammation Inflammatory intervention study IκB MAPK marker Metabolic diseases metabolic disorder MMP9 modulate molecular molecular mechanism Multiple neurodegenerative Nrf2 nuclear pathway Patient polyphenols Polyunsaturated protein kinases public health real-life risk simulation reduced reducing Resilience risk School significantly STAT3 Transcription [DOI] 10.3390/ijerph17114135 PMC 바로가기 [Article Type] Review
Redox-Modulating Agents in the Treatment of Viral InfectionsReview Published on 2020-06-082023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] antioxidants COVID-19 Influenza Nrf2 redox state reduced glutathione (GSH) viral infections [DOI] 10.3390/ijms21114084 PMC 바로가기 [Article Type] Review
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19Review Published on 2020-05-062022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activity acute respiratory syndrome affected antioxidant articles caused China Clinical management Clinical studies clinically Complication Controlled clinical trial coronavirus COVID-19 disease Effect effective experimental model expression homeostasis IL-1β IL-6 Inflammation Inflammatory diseases Keap1/Nrf2/ARE pathway management mechanism of action modulation molecular mechanism NF-κB Nrf2 organ organ damage outbreak oxidative stress ozone therapy 1 pathway peer-reviewed physiological Potential Research SARS-CoV-2 shown Support systemic therapy tissue damage viral infection viral infections [DOI] 10.3390/antiox9050389 PMC 바로가기 [Article Type] Review
Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier FunctionOriginal Research Published on 2019-11-212024-09-02 Journal: Frontiers in Pharmacology [Category] 대상포진, [키워드] Huang-lian-Jie-du Decoction Inflammation Mucosal protection NF-κB Nrf2 oxidative stress ulcerative colitis [DOI] 10.3389/fphar.2019.01354 PMC 바로가기 [Article Type] Original Research
Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and PathogenesisReview Published on 2019-09-192023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] hepatitis C virus Hepatits B virus liver regeneration Nrf2 reactive oxygen species [DOI] 10.3390/ijms20184659 PMC 바로가기 [Article Type] Review
Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposureOriginal Research Published on 2017-09-212023-06-03 Journal: Cancer Medicine [Category] B형 간염, [키워드] aflatoxin B1 Hepatitis B virus Hepatocellular carcinoma Nrf2 p62 [DOI] 10.1002/cam4.1176 PMC 바로가기 [Article Type] Original Research