Open reading frame – Page 5 – Communicable Diseases Research

Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting

프로그래밍 된 -1 리보솜 프레임 시프 팅을 목표로하여 SARS-COV-2 복제의 제한

407

Published on 2021-06-292022-08-13
Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS,

Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters

COVID-19 패밀리 클러스터로부터 분리 된 SARS-COV-2의 분자 역학

Research

Published on 2021-06-012022-09-01
Journal: BMC Medical Genomics [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] Amino acid Analysis change clade Cluster Clusters collected Combination COVID-19 COVID-19 severity D614G D614G mutation dataset Deceased disease epidemiological data Epidemiology Families family Family cluster Frame Genome highlight Illumina Miseq Indonesia Infection involved Multiple spike protein mutations Mutation mutations next-generation sequencer nucleic acid Open reading frame ORF outcomes Patient patients patients with COVID-19 Phylogenetic analysis Protein Q677H regions Result resulting SARS-CoV-2 SARS-CoV-2 transmission sequence sequences SNP Spike protein supplementary material survived transmission of SARS-CoV-2 virus virus sample virus samples viruses was performed Whole genome sequencing
[DOI] 10.1186/s12920-021-00990-3 PMC 바로가기 [Article Type] Research

Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein–Protein Docking, Molecular Dynamics, and MM-GBSA Calculations

Article

Published on 2021-05-272022-10-29
Journal: Journal of Chemical Information and Modeling [Category] COVID-19, MERS, SARS,

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

SARS-CoV-2에 의한 인터페론 길항작용: 역유전학을 이용한 기능적 연구

Article

Published on 2021-05-012022-09-11
Journal: The Lancet. Microbe [Category] Fulltext, SARS, 변종, 치료제,

[키워드] Activation acute respiratory syndrome adaptive Amino acid amino acid substitution amino acid substitutions amino acids analysed Analysis antagonistic backbone Bildung Calu Calu-3 cell calu-3 cells camostat camostat mesilate Cell cell entry cell line cellular entry receptor changes COVID-19 cytokine domain ENCODE Epidemic evaluate evaluated expressed fitness Frame functional gene induction Genes Genetic genetic engineering genetics homologous homology host cell host cells interfere interferon interferon antagonism interferon treatment interferon-stimulated gene interferon-stimulated genes investigated IRF3 less luciferase Mutagenesis mutant MX1 nuclear translocation Open reading frame ORF6 phenotype phenotypic Protein Replication residue residues RT-PCR SARS-CoV SARS-CoV-2 SARS-CoV-2 protein sensitivity Severe acute respiratory syndrome strain Strains suppressed TMPRSS2 transcription factor transmission efficiency Treatment type I interferon Vero E6 Vero E6 cell VERO E6 cells virus wild-type
[DOI] 10.1016/S2666-5247(21)00027-6 PMC 바로가기 [Article Type] Article

Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity

초기 유행병 동안 SARS-CoV-2 감염의 게놈 역학 및 질병 중증도와의 연관성

Research

Published on 2021-04-262022-09-10
Journal: JAMA Network Open [Category] MERS, SARS, 변종,

[키워드] 95% CI Admission age Alter Analysis association circulation clade clades Cleveland clinic clinical outcomes clinical risk Community complex creatinine cross-sectional cross-sectional study D614G Data analysis demonstrated died disease disease severity explain finding followed by Frame Frequency Genotype group help Hospitalization Hospitalized ICU ICU admission Identified Importance Increased increased survival infected with SARS-CoV-2 Infection Influenza initial initiative intensive care intensive care unit Kruskal-Wallis Laboratory male measure median Mortality mortality rates multivariable analysis objective occurred Odds ratio Open reading frame ORF ORF8 other variants outcome outcomes overall mortality pandemic progresses participant Patient patient survival patients with SARS-CoV-2 Point reduction in Relevance required Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants setting several variants significantly specimen specimens spike strain Strains Stratification the patient understanding unique variant variants Viral viral genome viral genome analysis Viral genome sequencing virus was performed Wave white
[DOI] 10.1001/jamanetworkopen.2021.7746 PMC 바로가기 [Article Type] Research

Analysis of IgM, IgA, and IgG isotype antibodies Directed against SARS-CoV-2 spike glycoprotein and ORF8 in the course of COVID-19

COVID-19 과정에서 SARS-CoV-2 스파이크 당단백질 및 ORF8에 대한 IgM, IgA 및 IgG 이소타입 항체 분석

Article

Published on 2021-04-262022-09-01
Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgM antibodies antibody cross-reactivity Antigen best clinical parameter Clinical parameters Combination coronavirus Course COVID-19 cross-reaction cross-reactions CRP diagnostic ELISA Evidence evidence of Frame identify IgA IgG IgG isotype antibodies IgG isotype antibody IgM IgM antibodies IL-6 immune response Immunity immunoassay immunoassays immunoblot Immunoblot analysis immunoglobulins infected patients Infection Inflammation information kidney LDH Liver injury no correlation Open reading frame ORF8 parameter positive patients presence of antibody Protein question Reactions reliability respiratory SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 patients SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike glycoprotein sensitivity serological serum immunoglobulin serum immunoglobulins serum sample serum samples specificity spike glycoprotein tested the disease viral infection
[DOI] 10.1038/s41598-021-88356-8 PMC 바로가기 [Article Type] Article

Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data

Method

Published on 2021-04-012022-10-31
Journal: Genome research [Category] COVID-19, SARS,

Evaluation of SARS-CoV-2 in Tears of Patients with Moderate to Severe COVID-19

중등도에서 중증 COVID-19 환자의 눈물에서 SARS-CoV-2 평가

Article

Published on 2021-04-012022-09-11
Journal: Ophthalmology [Category] SARS, 치료기술,

[키워드] 48 hour 48 hours amplification curve Analysis Chain Reaction collected Comorbidities conjunctival Conjunctival swab coronavirus disease Coronavirus disease 2019 COVID-19 cross-sectional study Ct value Ct values cycle threshold E gene enrolled eye Frame gold gold standard group laboratory confirmation manifestation median value moderate moderate disease moderate to severe nasopharyngeal Nasopharyngeal swab ocular Open reading frame outcome Patient patients patients with moderate polymerase chain polymerase chain reaction positive positive result positive RT-PCR profiles real-time RT-PCR reverse-transcriptase polymerase chain reaction RNA-dependent RNA polymerase RT-PCR analysis RT-PCR assay Sample SARS-CoV-2 SARS-CoV-2 RNA severe coronavirus disease severe COVID-19 severe disease significantly higher specimen statistically significant Swab Symptomatology systemic symptoms Tear tears threshold transported Viral load Viral transmission viral transport media was determined
[DOI] 10.1016/j.ophtha.2020.08.029 PMC 바로가기 [Article Type] Article

Analysis of SARS-CoV-2 mutations in Mexico, Belize, and isolated regions of Guatemala and its implication in the diagnosis

멕시코, 벨리즈 및 과테말라의 고립 지역에서 SARS-CoV-2 돌연변이 분석 및 진단에 미치는 영향

Article

Published on 2021-04-012022-09-11
Journal: Journal of medical virology [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected aligned Amino acid amino acid substitution Analysis analyzed Belize CDC circulating Clustal Omega Complete coronavirus D614G Diagnosis diagnosis of COVID-19 diagnosis of SARS-CoV-2 ExPASY for inclusion Genetic Genetic variation genomic sequence GISAID database greater host genome identify increase in Missense Mutation mutations NC_045512.2 Open reading frame open reading frames ORF8 polyprotein positive primer Primers Region reported SARS Coronavirus SARS-CoV-2 SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 mutation sequence sequences Seven severe acute respiratory syndrome Coronavirus South specificity Spike protein Spread spread to Substitution substitutions synonymous translated UCSF Chimera United State United States variant virulence virulent virus Wuhan Wuhan, China
[DOI] 10.1002/jmv.26591 PMC 바로가기 [Article Type] Article

1 H, 13 C, and 15 N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein)

Article

Published on 2021-03-262022-10-27
Journal: Biomolecular Nmr Assignments [Category] COVID-19,

[키워드] 5′ untranslated region backbone biochemical C-terminus caused cleaved complexes coronavirus 2 COVID-19 COVID-19 pandemic domain drug target element ENCODE facilitate full-length SARS-CoV-2 Health Host immune function Interaction Lung disease N-terminal domain New drug targets NMR NMR spectroscopy non-structural protein non-structural proteins nsp1 Open reading frame ORF1a ORF1b ORFs overlapping physiological function polyprotein Protein Proteins Research respiratory RNA SARS-CoV-2 SARS-CoV-2 genome secondary structure Support suppresse the SARS-CoV-2 genome translation Treatment UTR Viral RNA virulence
[DOI] 10.1007/s12104-021-10019-6 PMC 바로가기 [Article Type] Article