Molecular Mechanism of Action of Repurposed Drugs and Traditional Chinese Medicine Used for the Treatment of Patients Infected With COVID-19: A Systematic Scoping ReviewPharmacology Published on 2021-02-122022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Action active sites alternative medicine analyzed article attenuate binding Chinese Chloroquine clinical trial Combination complementary COVID-19 COVID-19 disease database drug effective drugs enzyme Favipiravir Government inclusion criteria Inflammation information inhibit Jin Medicine molecular molecular mechanism oseltamivir outbreak pandemic pathway Patient proliferation Remdesivir Repurposed drug Repurposed drugs Research review Ritonavir SARS-CoV-2 TCM the SARS-CoV-2 virus Traditional treat Treatment triggering Vaccine [DOI] 10.3389/fphar.2020.585331 PMC 바로가기 [Article Type] Pharmacology
Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach고 처리량 컴퓨터 스크리닝 및 구조 역학 접근을 통한 SARS-COV2의 NSP15에 대한 약물 설계Article Published on 2021-02-052022-09-11 Journal: European journal of pharmacology [Category] SARS, 신약개발, 치료제, [키워드] (lopinavir (ritonavir) addition approach best binding binding affinity butanamide complement Compound computational analysis contribute COVID-19 Critical dataset dihydrofuran-2(3H)-one drug drug candidate effective endonuclease ethyl explicit Favipiravir feature generate High Throughput Screening host immune system identify Interference lead Lopinavir molecular dynamics molecular dynamics simulations Nsp15 oseltamivir outbreak pandemic pharmacophore potential therapeutic target Protein pyrazine Replication Ritonavir rule SARS-CoV2 screened selected selective small molecule therapeutic training set Treatment unique virulence was selected [DOI] 10.1016/j.ejphar.2020.173779 PMC 바로가기 [Article Type] Article
All-cause mortality among patients treated with repurposed antivirals and antibiotics for COVID-19 in Mexico City: A real-world observational studyOriginal Article Published on 2021-02-042022-10-31 Journal: EXCLI Journal [Category] COVID-19, [키워드] acyclovir age all-cause mortality amantadine Antibiotics Antiviral antivirals benefit COVID-19 Critical death eliminated estimating equations evaluate General population group Hospitalized increased mortality increased risk laboratory-confirmed limit men Mexico City modify Mortality mortality risk multivariable n=36 occurred oseltamivir Patient patients patients evaluated patients treated performed pharmacoepidemiology positive RT-PCR Pregnancy propensity score matching protective factor receiving retrospective cohort study Rimantadine risk risk factor SARS-CoV-2 sub-cohort survival treated zanamivir [DOI] 10.17179/excli2021-3413 PMC 바로가기 [Article Type] Original Article
Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A VirusArticle Published on 2021-02-032022-10-28 Journal: Viruses [Category] COVID-19, 신종인플루엔자, [키워드] acute infections addition Antiviral antiviral response ATPase block broad-spectrum common cold coronavirus coronavirus coronavirus OC43 COVID-19 vaccine derivatives disease effective Effective vaccines H1N1 Host Human immortalized include induce Infection influenza A virus Influenza virus inhibit inhibitor inhibitory innate immune Innate immunity Major mice mouse OC43 oseltamivir primary human cells Remdesivir Replication respiratory respiratory syncytial virus respiratory virus ribavirin RSV SARS-CoV-2 significantly thapsigargin treat vaccination virus [DOI] 10.3390/v13020234 PMC 바로가기 [Article Type] Article
Perceptions of Romanian Physicians on Lockdowns for COVID-19 PreventionArticle Published on 2021-01-182022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] acute respiratory syndrome approach catch change clinical picture contrary convalescent plasma coronavirus COVID-19 COVID-19 patients COVID-19 vaccine diagnostic disease effective Efficiency Healthcare systems Hydroxychloroquine initial Intention involved limit literature review lockdown measure Measures MOST oseltamivir pandemic Perception physician physicians’ perception prevention Protective questionnaire Registered rejection remained Romania SARS-CoV-2 SARS-CoV-2 treatment significantly Spread survey the disease therapeutic option thought Tocilizumab Treatment triggering Vaccine [DOI] 10.3390/healthcare9010095 PMC 바로가기 [Article Type] Article
Co-infection of COVID-19 and influenza A in a hemodialysis patient: a case reportCase Report Published on 2021-01-132022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome Admission Bacterial Case report caused Chest Clinical symptoms Clostridioide Co-infection Community concerning consolidation Contact coronavirus Coronavirus disease 2019 cough COVID-19 COVID-19 outbreak demonstrated dialysis diarrhea disease droplet elevated End-stage renal disease ESRD explain Fever flu flu-like symptoms Gastrointestinal green diarrhea healthcare facility Hemodialysis high risk High-risk patients Influenza influenza A influenza viruses initial Isolation Like Local Medicine Mild Nasopharyngeal swab nausea Novel coronavirus oseltamivir pandemic pathogen Patient Pneumonia polymerase chain positive Rapid RT-PCR SARS-CoV-2 Shortness of breath sick Spread supportive care thought tomography transmitted Travel virus vomiting WBC White blood cell WHO World Health Organization worsening worsening cough Wuhan, China [DOI] 10.1186/s12879-020-05723-y PMC 바로가기 [Article Type] Case Report
A retrospective comparison of drugs against COVID-19Comparative Study Published on 2020-12-142022-10-04 Journal: Virus research [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제, [키워드] analyzed Antibody detection Arbidol combination therapy coronavirus disease 19 Corticosteroid Corticosteroids COVID-19 drug Drug repurposing Effect exhibited four group General population groups Hospital stay Hydroxychloroquine hydroxychloroquine group IgG level IgM indicated Lopinavir/ritonavir management monotherapy oseltamivir outcome pandemic patients treated reduced retrospective SARS-COV-2 infection serological significantly significantly higher significantly shorter threat [DOI] 10.1016/j.virusres.2020.198262 PMC 바로가기 [Article Type] Comparative Study
The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational studyObservational Study Published on 2020-12-012022-10-05 Journal: Daru : journal of Faculty of Pharmacy, Tehran Univ [Category] 임상, [키워드] Abstract average both group C-reactive protein (CRP changed clinically Combination combination regimen combination therapy Coronavirus disease 2019 COVID-19 determine disease effective therapy Efficacy Evidence Follow-up hospital Hydroxychloroquine indicated Inpatient Iran laboratory parameter laboratory-confirmed lack Length Length of stay in hospitals (ALOS). low-dose prednisolone Novel coronavirus oseltamivir outcome oxygen saturation pandemic Patient patients pharmacological Platelet Pneumonia positive Prednisolone receiving regimen retrospective Serum level significant difference SpO2 suffering Tehran temperature the patient therapeutic strategy therapy for COVID-19 two groups were recorded with COVID-19 [DOI] 10.1007/s40199-020-00353-w PMC 바로가기 [Article Type] Observational Study
A comparative analysis for anti-viral drugs: Their efficiency against SARS-CoV-2Review Published on 2020-11-302022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 치료제, [키워드] addition Analysis analyzed anti-inflammatory agent Anti-viral anti-viral drug Brazil candidate China Chloroquine Combination confirmed case confirmed COVID-19 case coronavirus Corticosteroids country COVID-19 Critical Cytokine storm death deaths drug drug candidate Effects Efficiency Favipiravir Germany Hydroxychloroquine inhibit Italy Lung injury mechanism of action organ dysfunction oseltamivir pandemic Patient patients Prevent Remdesevir Remdesivir reported Russia SARS-CoV-2 scientist South Korea Spain Spread synergistic Treatment treatments of COVID-19 Turkey umifenovir USA Vaccine [DOI] 10.1016/j.intimp.2020.107232 PMC 바로가기 [Article Type] Review
Point-of-care molecular testing and antiviral treatment of influenza in residents of homeless shelters in Seattle, WA: study protocol for a stepped-wedge cluster-randomized controlled trial워싱턴주 시애틀의 노숙자 보호소 거주자를 대상으로 한 현장 진료 분자 검사 및 인플루엔자 항바이러스 치료: 계단식 쐐기형 클러스터 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2020-11-232022-09-10 Journal: Trials [Category] SARS, 임상, 치료제, [키워드] acute respiratory illness Administered age Analysis Antiviral treatment ARI baloxavir Comorbidities Complete control arm Controlled trial defined demographics eligible Enrollment evaluate health problem homeless shelter Homeless shelters implementation incidence individual Influenza information Intervention intervention arm molecular nine oseltamivir participant point-of-care positive primary endpoint public health questionnaire Randomized reduce respiratory respiratory symptom Seattle severity Site Spread Study protocol supplementary material Surveillance symptom duration symptom onset Symptoms tested timepoint Trial Trial registration University of Washington Washington worsening cough [DOI] 10.1186/s13063-020-04871-5 PMC 바로가기 [Article Type] Study Protocol