Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
p53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다
Research Article
[키워드] activated
Activation
alternative NF-κB pathway
Analysis
ANAPC1
c-Rel
cancer cell
Cancer cells
CD40
CD40 ligand
CD40L
CDK4
CDK6
Cell
cell cycle
cell senescence
cellular senescence
ChIP
chromatin immunoprecipitation
chronic
chronic lymphocytic leukemia
classical
complexes
Crosstalk
de-repression
defined
Degradation
DEK
dependent on
Effect
effector
effectors
expression
EZH2
fibroblasts
Hematological malignancies
Hematological malignancy
IKK
IKKα
induce
inhibit
investigated
IκB
IκBα
knockdown
leads
Loss
Lymphocytic leukemia
mechanism
microarray analysis
microenvironment
NEMO
NF-κB
NF-κB inducing kinase
NF-κB pathway
NF-κB2
NIK
or canonical
oxygen
p100
p21WAF1
p52
p53
pathway
patients
phenotype
Phosphorylation
polycomb protein
promote
protein stability
provide
PSMA5
quantitative PCR
RacGAP1
reactive oxygen species
reactive oxygen specy
regulate
Regulation
regulatory subunit
RELA
RelB
repression
retinoblastoma
retinoblastoma protein
ROS
SASP
senescence
senescent
siRNA
solid tumors
stability
stimulated
subset
subunit
subunits
suppress
suppression
target gene
Target genes
the cell
Tumor
tumor suppressor
tumorigenesis
tumors
tumour suppressor
turn
western blot
Western blot analyses
Western blot analysis
wild type
[DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article