Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease새로운 인간 USP2 억제제의 식별 및 SARS-CoV-2 파파인 유사(PLpro) 프로테아제를 억제함으로써 COVID-19 치료에서 추정되는 역할Article Published on 2020-12-012022-09-11 Journal: Computational biology and chemistry [Category] SARS, 신약개발, 치료제, [키워드] adopted analyzed antiviral target asparagine aspartate assays best binding binding site carboxyl catalytic Cell Compound Consensus conserved COVID-19 COVID-19 outbreak Deubiquitination followed by functional H-bond interaction histidine Human identification identify implication in-silico In-vitro inhibit inhibiting inhibitor inhibitors innate immune response lack lead leukemia MD simulations molecular docking molecular interaction Papain Papain-like protease PLPro protease Proteases protocol reported residue SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 papain-like protease (PLpro) selected tested Treatment Ubiquitin-specific protease 2 (USP2). urgency USP USP2 Virtual screening [DOI] 10.1016/j.compbiolchem.2020.107376 PMC 바로가기 [Article Type] Article
The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors코로나바이러스 세포 진입 및 복제에서 시스테인 펩티다제의 역할: 카텝신 억제제의 치료 가능성Review Published on 2020-11-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, [키워드] Activation antiviral drug cathepsin inhibitor Cathepsins cell entry cells chymotrypsin Coronaviral coronavirus CoV CoVs cysteine Diseases generate Host host cell humans inhibitor involved lysosomal nonstructural protein nonstructural proteins Nsps outcomes over Papain peptidase positive-sense prevalent processed replicase polyprotein replicase polyproteins Replication respiratory respiratory diseases RNA viruses severe respiratory diseases single-stranded spike glycoprotein spike glycoproteins Spike protein targets therapeutic potential treatment strategy utilization Viral Viral RNA viral RNA synthesis virus attenuation [DOI] 10.1371/journal.ppat.1009013 PMC 바로가기 [Article Type] Review
Optimized Ciclopirox-Based Eudragit RLPO Nail Lacquer: Effect of Endopeptidase Enzyme as Permeation Enhancer on Transungual Drug Delivery and Efficiency Against Onychomycosisarticle Published on 2018-04-302024-09-01 Journal: AAPS PharmSciTech [Category] 백선증, [키워드] ciclopirox confocal laser spectroscopy Nail lacquer Papain transungual delivery [Article Type] article