Liposome encapsulated clodronate mediated elimination of pathogenic macrophages and microglia: A promising pharmacological regime to defuse cytokine storm in COVID-19Review article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, 치료제, [키워드] activated macrophage Activation administration adverse effect alleviate Brain Clinical management Clodronate COVID-19 COVID-19 vaccine COVID-19 vaccines Cytokine storm death depleting discharge dysregulation encapsulation event Factor Host immune response immunogenic reaction immunological induce Inflammation life-threatening Liposomal clodronate Liposome Macrophage microglia microglial microglial cell Mortality multiorgan failure new SARS-CoV-2 offer pathogenic phagocytic cell pharmacological positive proinflammatory public health reactive reported resulting SARS-CoV-2 infected individuals SARS-COV-2 infection therapeutic strategy variant while [DOI] 10.1016/j.medidd.2022.100136 [Article Type] Review article
Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central ChinaArticle Published on 2022-08-312023-05-31 Journal: Microbiology Spectrum [Category] 신종인플루엔자, 조류인플루엔자, [키워드] Avian influenza virus pathogenic Reassortment Viral surveillance wild birds [DOI] 10.1128/spectrum.01652-22 PMC 바로가기
A Multitrait Locus Regulates Sarbecovirus PathogenesisArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis approach CCR9 chromosome 9 collaborative cross conserved coronavirus coronavirus disease Coronavirus infection cross CXCR6 disease facilitate Follow-up Genes Genetic genetic determinant genetic mapping Genetic variation GWAS help highly pathogenic Host host response host susceptibility humans identify implementation Infection Infectious disease influence loci locus mice Mortality mouse model outcome outcomes Pathogenesis pathogenic Precision predict Protective regulate sarbecovirus Sarbecoviruses sarbecoviruses. SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 infections severe disease severity strain susceptibility susceptibility allele variety Viral diseases Virus Disease [DOI] 10.1128/mbio.01454-22 PMC 바로가기
Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 ProteaseArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] SARS, 변종, 치료기술, [키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1 [DOI] 10.1128/mbio.01376-22 PMC 바로가기
Novel insight on marker genes and pathogenic peripheral neutrophil subtypes in acute pancreatitisArticle Published on 2022-08-222022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] Activation acute pancreatitis addition Analysis analyzed bioinformatic analysis Biomarkers Combination coronavirus disease COVID-19 COVID-19 patients Critical expression data facilitate functional gene gastrointestinal disease Gene Expression investigated Local machine-learning marker gene mechanism morbidity neutrophil novel pathogenic pathway patients Peripheral blood peripheral blood cell predictor prognostic Research S100A12 S100A6 S100A9 Sequencing sequencing data single-cell single-cell sequencing subtype WGCNA [DOI] 10.3389/fimmu.2022.964622 PMC 바로가기
Anti-neuronal antibodies against brainstem antigens are associated with COVID-19Article Published on 2022-08-112022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Affect AIFM1 antibody Antigen appear assisted ventilation Autoimmunity Brainstem Control controls Course COVID-19 patient COVID-19 patients DAB1 determine diagnostic Disabled Economy elevated Encephalitis epitope Epitopes finding foundation funding Germany Greifswald group help homolog hypothesised IgG IgG and IgM IgG level IgM implicated in both groups initiative intensive care Invasion long-COVID marker Medicine Microarray Mild Occurrence pathogenic pathway Patient peptide epitope predicted responsible SARS-CoV-2 serum severe disease severely ill patient significantly state Support SURF1 the disease therapeutic understanding university unlikely with COVID-19 [DOI] 10.1016/j.ebiom.2022.104211 [Article Type] Article
Cardiovascular markers and COVID-19Research article Published on 2022-08-022022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 바이오마커, 진단, [키워드] Acute cardiac injury Acute myocardial infarction adverse outcome arrhythmia Biomarker BNP BNP /NT-proBNP cardiovascular cardiovascular complication Cardiovascular markers contributing to COVID-19 Data analysis Evolution heart failure heterogeneous highlight include marker mechanism Mortality myocardial damage myocarditis Pathogenesis pathogenic Patient proportion risk severe disease Troponin and d-dimer Variability Venous Thromboembolism viral disease [DOI] 10.1016/j.matpr.2022.07.388 [Article Type] Research article
Heterogeneity in IgG-CD16 signaling in infectious disease outcomesArticle Published on 2022-08-012022-11-15 Journal: Immunological reviews [Category] 진단, [키워드] acute infections allele binding contribute coronavirus disease COVID-19 dengue disease disease downstream driven by effector functions. expression Fc afucosylation form functions glycosylation heterogeneity IgG IgG antibody IgG1 IgG1 antibodies immune complex Immune homeostasis Infection Infectious disease Inflammation Inflammatory response inflammatory signaling ligands mechanism modulate outcome Pathogenesis pathogenic required Signaling viral infection while [DOI] 10.1111/imr.13109 PMC 바로가기
Characterizing the microbiota of instrumentation in ophthalmology clinics during and beyond the COVID-19 pandemicCOVID-19 대유행 기간 동안 및 이후에 안과 진료소에서 기구의 미생물군 특성화Article Published on 2022-08-012022-09-12 Journal: Graefe's Archive for Clinical and Experimental Oph [Category] MERS, SARS, 진단, [키워드] 95% confidence interval Adenovirus Bacteria Bacterial calculated clinical implication clinics collected Corynebacterium COVID-19 COVID-19 pandemic Culture Descriptive statistics growth healthcare implicated Increased Infection Instrumentation luteus media Microbiome microbiota Micrococcus molecular MOST negative control no significant difference Nosocomial infection Novel coronavirus pandemic pathogen pathogenic Pathogens Patient PCR polymerase chain positive potential transmission Propionibacterium Retina risk Sample SARS-CoV-2 Spread Standard Staphylococcus tested threshold Transmission was performed were used [DOI] 10.1007/s00417-022-05639-0 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article