PD-L1 – Page 5 – Communicable Diseases Research

LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications

Immunology

Published on 2021-09-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Successful Treatment of Advanced Intrahepatic Cholangiocarcinoma With a High Tumor Mutational Burden and PD-L1 Expression by PD-1 Blockade Combined With Tyrosine Kinase Inhibitors: A Case Report

Article

Published on 2021-09-172023-06-03
Journal: Frontiers in Immunology [Category] B형 간염, Fulltext,

[키워드] conversion therapy Immunotherapy intrahepatic cholangiocarcinoma PD-L1 TMB
[DOI] 10.3389/fimmu.2021.744571 PMC 바로가기

Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns

중요한 COVID-19는 뚜렷한 백혈구 표현형 및 전사체 패턴과 관련이 있습니다

Article

Published on 2021-09-012022-09-11
Journal: Journal of internal medicine [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] (PD-1 activated adaptive Admission affecting Alpha analysed B cells B-cell Bacterial sepsis Blood calprotectin CD25 CD4 CD8 T cells characterized classical monocytes cohort study collected comparable controls COVID-19 COVID-19 patient COVID-19 severity Critical disease disease severity Exhaustion exhibited expression flow cytometry groups healthy control healthy controls HLA-DR Hospitalization immune function immune functions Immune phenotype Immune profile immune response Immunity innate and adaptive immunity leukocyte marker monocyte Monocytes mononuclear cell mononuclear cells naïve Non-classical monocytes pathway Patient PBMCs PD-1 PD-L1 peripheral Peripheral blood Peripheral blood mononuclear cells phenotype plasma Prognostic markers Protein receptor reduced RNA sequencing SARS-CoV-2 Sepsis severity T cell T cells T-cell therapeutic target therapeutic targets these cell These cells transcript Transcriptome transcriptomic transcriptomics WHO guideline with COVID-19
[DOI] 10.1111/joim.13310 PMC 바로가기 [Article Type] Article

Case Report: Complete Response of Primary Massive Hepatocellular Carcinoma to Anti-Programmed Death Ligand-1 Antibody Following Progression on Anti-Programmed Death-1 Antibody

Article

Published on 2021-08-242023-06-03
Journal: Frontiers in Immunology [Category] B형 간염, Fulltext,

[키워드] atezolizumab HCC Immunotherapy PD-1 PD-L1 Pembrolizumab
[DOI] 10.3389/fimmu.2021.712351 PMC 바로가기

Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

염증의 내인성 조절은 무증상 또는 무증상 SARS-CoV-2 감염이 있는 임산부의 특징입니다.

Article

Published on 2021-07-292022-09-10
Journal: Nature Communications [Category] SARS, 바이오마커,

[키워드] Activation Affect alteration anti-inflammatory cytokine anti-inflammatory cytokines antiviral immune response antiviral immune responses Asymptomatic Blood cells cell proliferation cytokine cytokine production Cytokines cytometry analysis D-dimer damages develop differentiation during pregnancy endogenous help heterogenous IL-10 IL-17 IL-6 Immune cell immune responses immunological change immunological changes increase in Inflammation Inflammatory interleukin lymphopenia marker mild SARS-CoV-2 infection mother neutrophil Neutrophils PD-L1 Peripheral blood plasma Plasma levels Pregnancy pregnant women preserved pro-inflammatory cytokines remain unchanged reported SARS-COV-2 infection Therapeutic strategies therapeutic strategy therapeutic target Translational immunology viral infection virus White blood cells
[DOI] 10.1038/s41467-021-24940-w PMC 바로가기 [Article Type] Article

Genomic profiling of solid tumors harboring BRD4-NUT and response to immune checkpoint inhibitors

Original Research

Published on 2021-07-292024-09-04
Journal: Translational Oncology [Category] 대상포진,

[키워드] BRD4 BRD4-NUT Checkpoint inhibitor NUT carcinoma NUT midline carcinoma PD-L1
[DOI] 10.1016/j.tranon.2021.101184 PMC 바로가기 [Article Type] Original Research

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

Research Article

Published on 2021-06-282022-10-28
Journal: PLoS ONE [Category] COVID-19,

Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype

심각한 COVID-19 회복은 골수 세포 면역 조절 표현형의 적시 획득과 관련이 있습니다

Immunology

Published on 2021-06-232022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] Aberrant inflammatory responses acquisition Activation Admission age and sex alteration Analysis basophil basophils best CD14 CD163 CD80 CD86 Cell circulating contribute COVID-19 COVID-19 outbreak cytokine Cytokine storm demonstrated dendritic cell described detectable discharge evaluated expansion expression flow cytometry HCs healthy control healthy controls healthy subjects ICU ICU Patients IFN-γ IL-10 IL-12p40 IL1RA immune-regulation increased expression Inflammatory responses innate immune system Innate immunity intensive care intensive care unit admission M2-like differentiation management marker mDCs mediators monocyte Monocytes myeloid myeloid cell pandemic pathogenic mechanism Patient patients patients with COVID-19 PD-L1 pDCs phenotype plasma positively correlated Prognosis reduced reduction Regulatory respiratory insufficiency SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe disease significantly significantly higher Slan specific antibodies stratified subset Support therapeutic agent therapeutic agents therapeutic interventions Treatment Viral Viral load
[DOI] 10.3389/fimmu.2021.691725 PMC 바로가기 [Article Type] Immunology

Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer

Article

Published on 2021-06-212022-10-04
Journal: Cell Death & Disease [Category] 바이오마커,

COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytes

COVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다

Research Article

Published on 2021-06-182022-09-10
Journal: JCI Insight [Category] MERS, 바이오마커,

[키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream
[DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article