Synthetic α-Helical Peptides as Potential Inhibitors of the ACE2 SARS-CoV-2 InteractionArticle Published on 2022-09-052023-07-09 Journal: Chembiochem [Category] COVID19(2023년), [키워드] CD spectroscopy peptides protein-protein interactions SARS-CoV-2 secondary structures. [DOI] 10.1002/cbic.202200372 PMC 바로가기
Serum peptidome profiles immune response of COVID-19 Vaccine administrationArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] activated acute respiratory syndrome administration Analysis analyzed Antigen Biomarker C1q caused CD59 CD99 Cellular immune response clinical trials collected Complete CoronaVac coronavirus Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine Efficacy Evidence glycoprotein help hemoglobin humoral immune immune response immunization immunogenicity analysis individual information Laboratory linear Logistic regression MALDI-TOF membrane protein NAb neutralizing antibody pandemic participant peptide peptides Peptidome performed Platelet profile Protein provided random receiving receptor reported Research SARS-CoV-2 serum serum sample Significant statistical analysis subunits Support SVM vaccination Vaccine Vaccines [DOI] 10.3389/fimmu.2022.956369 PMC 바로가기
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus spike stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 AntigenSARS-CoV-2 항원의 민감한 파지 기반 효소 연결 화학발광 면역분석을 위한 SARS-CoV-2 스파이크 S1 단백질에 특이적으로 결합하는 파지 펩티드의 발견Article Published on 2022-08-232022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] albumin Amino acid amino acid sequence amplification antigen recognition binding site bovine bovine serum albumin chemiluminescence immunoassay conditions COVID-19 pandemic detect diagnose Dissociation constant Economy Effect exhibited expressing healthcare high affinity hydrogen hydrogen bond network hydrophobic immunoassay Interaction molecular docking N-terminal domain peptide peptides phage probe Protein pseudovirus S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S1 SARS-CoV-2 S1 protein selective sensitive sensitivity serum albumin specificity spike Spread supported target target protein the S1 subunit the SARS-CoV-2 transducing transmembrane protein [DOI] 10.1021/acs.analchem.2c01988 PMC 바로가기 [Article Type] Article
Identification of Potential ACE2-Derived Peptide Mimetics in SARS-CoV-2 Omicron Variant Therapeutics using Computational Approaches전산 접근법을 사용한 SARS-CoV-2 오미크론 변이 치료제의 잠재적 ACE2 유래 펩티드 모방체 식별Article Published on 2022-08-182022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, [키워드] accelerated ACE2 Amino acid amino acids Analysis angiotensin Angiotensin converting enzyme-2 binding binding affinity canonical COVID-19 pandemic dependent on effort event Health Health Organization human infection identification indicated infection rate inhibit inhibition Interaction molecular dynamics Molecular dynamics simulation Mutation omicron path peptide peptides Potential RBD RBDs receptor Receptor binding domain SARS-CoV-2 therapeutic Therapeutics variant variants viral infection VoC WHO World Health Organization [DOI] 10.1021/acs.jpclett.2c01155 PMC 바로가기 [Article Type] Article
A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry병렬 반응 모니터링 질량 분석을 사용한 SARS-CoV-2 펩타이드 검출을 위한 빠르고 민감한 절대 정량 분석Article Published on 2022-08-152022-09-11 Journal: Journal of proteomics [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] Absolute quantification Clinical diagnosis clinics COVID-19 Ct values Early detection enrichment heat heat-inactivated high resolution high viral load investigated mass mass spectrometry Nasopharyngeal swab nasopharyngeal swab sample Orbitrap pandemic Patient peptide peptides positive positive patient positive patients PRM Protein quantification required RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 peptide sensitivity speed Surveillance swab samples the disease Viral load Viral protein Viral proteins [DOI] 10.1016/j.jprot.2022.104664 PMC 바로가기 [Article Type] Article
Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Commercialized kits to assess T-cell responses against SARS-CoV-2 S peptides. A pilot study in health care workersSARS-CoV-2 S 펩타이드에 대한 T 세포 반응을 평가하기 위한 상용화된 키트. 의료 종사자를 대상으로 한 파일럿 연구Article Published on 2022-08-122022-09-11 Journal: Medicina clínica [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody test antibody tests Automation BNT162b2-mRNA-COVID-19-vaccine Cell mediated immunity CLIA complement Concordance correlation COVID-19 detect dose ELISA English Ensayos de liberación Interferon-gamma feasibility first vaccination group groups HCW Health care worker IFNγ immune response Immunosuppressed individual Infection Inmunidad Mediada por Células interferon Interferon-gamma-release-assays mRNA natural infection number of sample number of samples peptides pilot study positive Quantitative ranged risk S-protein SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 S SARS-CoV-2 vaccines Sensitivity and specificity Spanish susceptible T-cell Response T-cell responses vaccine dose Vacuna BNT162b2-mRNA-COVID-19. [DOI] 10.1016/j.medcli.2021.09.013 PMC 바로가기 [Article Type] Article
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19Research article Published on 2022-08-052022-10-05 Journal: EBioMedicine [Category] SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 BAL BAL fluid bind Biomarker Bronchoalveolar lavage Bronchoalveolar lavage fluid Coagulation system complexes contribute coronavirus COVID COVID-19 Critical dysregulation explain extracellular traps finding funding help hydrolytic activity Hypothesis increased vascular permeability inflammatory chemokines kallikrein-kinin Kallikrein-kinin system Kallikreins Kinins Leuven mechanically ventilated mechanically ventilated patient median myeloperoxidase NETs Neutrophil extracellular trap observation occur oedema Patient patients without COVID-19 peptide peptides plasma potential treatment option receptor Research SARS-CoV-2 severe COVID-19 severe pulmonary disease Support thromboembolic complication thromboembolic complications Thromboinflammation tissue [DOI] 10.1016/j.ebiom.2022.104195 [Article Type] Research article
MALDI-TOF Mass Spectrometric Detection of SARS-CoV-2 Using Cellulose Sulfate Ester Enrichment and Hot Acid Treatment셀룰로오스 황산염 에스테르 농축 및 고온 산 처리를 사용한 SARS-CoV-2의 MALDI-TOF 질량 분석 검출Article Published on 2022-08-052022-09-11 Journal: Journal of Proteome Research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acid acute respiratory syndrome acute respiratory syndrome coronavirus affinity Algorithm approach aspartate cause Cellulose cellulose sulfate enrichment characterized contributing to coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 diagnosis demonstrated detection enrichment ester flight functional groups hot acid aspartate-selective hydrolysis hydrolysis MALDI-TOF MS marker mass mass spectrometry N protein nasal swabs nucleocapsid pandemic parameter peptide peptides processed proteomics rapid COVID-19 detection. SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sewage sulfate variety virus virus samples virus variant virus variants [DOI] 10.1021/acs.jproteome.2c00238 PMC 바로가기 [Article Type] Article