A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin심층적인 막 재구성이 플라스모디움 팔시파룸 감염 적혈구의 과립린과 퍼포린에 의한 용해에 대한 취약성을 정의한다.Original Research Published on 2021-05-192024-08-08 Journal: Frontiers in immunology [Category] 말라리아, [키워드] blood-stage malaria cholesterol granulysin perforin phosphatidylserine (PS) plasma membrane pore forming proteins (PFPs) [DOI] 10.3389/fimmu.2021.643746 PMC 바로가기 [Article Type] Original Research
Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology
FIB-SEM as a Volume Electron Microscopy Approach to Study Cellular Architectures in SARS-CoV-2 and Other Viral Infections: A Practical Primer for a VirologistSARS-CoV-2 및 기타 바이러스 감염에서 세포 구조를 연구하기 위한 부피 전자 현미경 접근 방식으로서의 FIB-SEM: 바이러스 전문의를 위한 실용적인 입문서Review Published on 2021-04-022022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] architecture automated beam Cell cellular electron electron microscopy experiment FIB-SEM in vitro study increasingly interactions ion beam iterative less Microscopy Other plasma membrane positive primer quantitation reveal room temperature SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses scanning electron microscopy Segmentation specimen temperature ultrastructure unique vEM Viral virological synapse Virologist viruses Visualization Volume volumeEM [DOI] 10.3390/v13040611 PMC 바로가기 [Article Type] Review
Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus TrackingResearch Article Published on 2021-03-302022-10-29 Journal: mBio [Category] Coronavirus, [키워드] average caused caveolae Cell cell membrane clathrin Clathrin-mediated endocytosis complex coronavirus Course CoV CoV infection CoVs Dissection dynamic Endocytic pathway endocytosis endosome endosome trafficking Endosomes epidemic diarrhea Epidemics Evidence exhibiting expand Human Infection late endosome late endosomes mechanism Mediated occurred Pathways PEDV penetrate Penetrating plasma membrane porcine epidemic diarrhea coronavirus recruitment severe disease single-virus tracking Structure structures Transport undergo viral fusion viruses [DOI] 10.1128/mBio.00256-21 PMC 바로가기 [Article Type] Research Article
Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation패혈증 상태의 내피병증: 혈관 내 응고에 대한 기계적 통찰력Review Published on 2021-03-082022-09-11 Journal: Critical Care [Category] 임상, [키워드] activated Activation Anticoagulant Antithrombin Cell Coagulation coagulation factor Coagulation factors coagulation pathway conditions COVID-19 decrease Disseminated intravascular coagulation (DIC) domain Endothelial cell endothelial cells endotheliopathy example expression Extracellular histones function In vitro studies inhibitor intravascular coagulation Lipopolysaccharide (LPS) pathophysiology pathway Phosphatidylserine physiological plasma plasma membrane proof Protein protein C Proteins recombinant thrombomodulin resulting Sepsis septic supplementary material suppressed thrombomodulin thrombosis tissue Tissue Factor [DOI] 10.1186/s13054-021-03524-6 PMC 바로가기 [Article Type] Review
Elucidating the Antiviral Mechanism of Different MARCH FactorsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] antiretroviral Antiviral Cell comprehensive analysis E3 ubiquitin ligases envelope glycoproteins Factor glycoprotein HIV-1 homologues host restriction factors Human immunodeficiency virus Immunity Infection information intrinsic mechanism Murine leukemia virus plasma membrane Protein Proteins recent reducing restrict retrovirus retroviruses shown transmembrane protein virions viruses [DOI] 10.1128/mBio.03264-20 PMC 바로가기 [Article Type] Research Article
The H + -ATPase (V-ATPase): from proton pump to signaling complex in health and diseaseTheme Published on 2021-03-012022-10-28 Journal: American journal of physiology. Cell physiology [Category] COVID-19, MERS, SARS, [키워드] acidification activity addition Cancer Cell cell membranes cell type cell types cells cellular processes complex contributing to COVID-19 pandemic diabetes disease Diseases Endosomal acidification endosomal trafficking eukaryotic event Extracellular Factor function Health implication include increasingly Interaction interactions intracellular vesicle involved kidney male mucosa neurodegenerative occur olfactory organ system pathophysiological pathophysiology pH regulation physiological plasma membrane Protein proton gradient proton pumping ATPase Regulation reproductive Signaling transmembrane V-ATPase viral infection [DOI] 10.1152/ajpcell.00442.2020 PMC 바로가기 [Article Type] Theme
The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptorCoronaviruses Published on 2021-02-272022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 ACE2-expressing cell addition antagonized antiviral activity appear bind binding bovine Cell culture cell entry Coronavirus disease 2019 COVID-19 drug candidate effective experiment HCoV-229E HCoV-NL63 HCoV-OC43 heparan sulfate heparin host cell human coronavirus in vitro infect Interaction lack lactoferrin local concentration mechanism of action N-terminal pandemic plasma membrane Proteoglycan recent Remdesivir SARS-CoV-2 SARS-CoV-2 cell shown subsequent synergistic therapeutic interventions therapy viral replication viral spike protein [DOI] 10.1080/22221751.2021.1888660 PMC 바로가기 [Article Type] Coronaviruses
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptorIpomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다125 Published on 2021-02-152022-09-10 Journal: Journal of Cell Science [Category] MERS, 치료제, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses [DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entryArticle Published on 2021-02-112022-10-04 Journal: Nature Communications [Category] MERS, 진단, 치료제, [키워드] ACE2 Affect affecting angiotensin-converting enzyme 2 Cell cleavage site clone Coronaviruses CRISPR Critical disrupting endosomal entry pathway entry of SARS-CoV-2 expression Factor genome-wide CRISPR screen highlight Host identify insertion modulating multi-basic cleavage site plasma membrane public health reduced regulate residue Restriction factors S1/S2 S1/S2 boundary S1/S2 site SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein Spread subunit Transmission virus virus entry [DOI] 10.1038/s41467-021-21213-4 PMC 바로가기 [Article Type] Article