Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spikeArticle Published on 2022-10-062022-11-16 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] analyses Analysis antigenic variation complex COVID-19 Critical Deletion exacerbated fine-tune flexible functional Health Host Immunity mechanism membrane fusion Modification modulate Mutation N-terminal domain NTD omicron polymorphism receptor engagement remained responsible reveal Sarbecoviruses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant spike spike glycoprotein spike stability variant variants Variation Viral transmission virus entry [DOI] 10.15252/embr.202154322 PMC 바로가기
Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational StudyArticle Published on 2022-10-022022-11-16 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 gene acute respiratory syndrome allele Angiotensin receptors angiotensin-converting enzyme-2 candidate caused coronavirus correlation COVID-19 COVID-19 disease COVID-19 pandemic disease evaluate gene polymorphism genetic susceptibility Hospitalization host cell host receptor identify increased risk intensive care Patient polymorphism Prospective recent risk Risk factors rs2285666 rs4646156 SARS-CoV-2 SARS-COV-2 infection severe disease course severity severity of COVID-19 single nucleotide Single nucleotide polymorphism statistically significant target cells the SARS-CoV-2 virus triggered variant virus [DOI] 10.3390/ijerph191912622 PMC 바로가기
Friend or foe: RIG- I like receptors and diseasesArticle Published on 2022-10-012022-11-15 Journal: Autoimmunity reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation anti-tumor immunity antibody Antiviral antiviral immune response Autoimmune diseases autoinflammatory disease Autoinflammatory diseases Bacterial infections cascade disease Diseases Friend genes encoding Guidance Host IFNs immunomodulatory therapy include involved malaria MDA5 mechanism mechanisms microRNA miRNAs Mutation polymorphism post-translational modification proinflammatory cytokines Proteins recent finding receptor Regulatory RIG-I RLR RLRs RLRs. RNA virus SARS-CoV-2 Signaling single-nucleotide SNPs transcriptional type I interferon [DOI] 10.1016/j.autrev.2022.103161 PMC 바로가기
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기
APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus GenomeArticle Published on 2022-09-132023-06-12 Journal: The Journal of Infectious Diseases [Category] B형 간염, [키워드] Africa APOBEC3C editing Hepatitis B virus nucleotide context patients polymorphism [DOI] 10.1093/infdis/jiac003
COVID-19 infection and transmission includes complex sequence diversityArticle Published on 2022-09-082022-11-15 Journal: PLoS Genetics [Category] SARS, 변종, 진단, [키워드] allele approach biallelic complex consensus sequence COVID-19 infection COVID-19 pandemic Delta Donor Evolution heterogeneity heterogeneous include Infection infections investigator Lineage majority microbial nucleotide change Occurrence omicron pandemic pathogen Patient polymorphism recipients reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 sequence sequence sequence variation Sequencing significantly SNP tested Transmission Transmission dynamics transmitted variant variants variants of concern viral genome whole genome [DOI] 10.1371/journal.pgen.1010200 PMC 바로가기
Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19Article Published on 2022-09-072022-11-15 Journal: Viruses [Category] SARS, 치료기술, 치료제, [키워드] ACE2 receptor anti-SARS-CoV-2 antibody cellular protease COVID-19 COVID-19 disease disease dominant exonuclease Genetic genetic susceptibility Genotype Haplotype high risk individual Infection lactic acid dehydrogenase LDH Patient patients with COVID-19 polymorphism Polymorphisms Protective risk risk of COVID-19 RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serine TaqMan assays target cells the SARS-CoV-2 TMPRSS2 transmembrane transmembrane serine protease-2 (TMPRSS2). with COVID-19 [DOI] 10.3390/v14091976 PMC 바로가기
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, BrazilArticle Published on 2022-09-052022-11-16 Journal: BioMed Research International [Category] SARS, 변종, 유전자 메커니즘, [키워드] activated allele association Asymptomatic Brazil CARD8 center clinical clinical evolution Clinical management clinical manifestations contributing to COVID-19 COVID-19 severity death disease disease severity Factors Genetic Genetic variant Genotype group Haplotype Host host cells Inflammasome Inpatient investigated knowledge logistic regression models mechanism moderate NLRP3 NLRP3 inflammasome outcomes Patient performed polymorphism Polymorphisms profile protection Real-time PCR recruited Rio de Janeiro risk risk factor SARS-COV-2 infection SARS-CoV-2-infected individual scale severe symptom severity Significant single-nucleotide SNP SNPs Symptom the WHO two group two groups variants virus was determined WHO with mild disease [DOI] 10.1155/2022/9082455 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortalityResearch article Published on 2022-09-012022-10-05 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, [키워드] 25-hydroxyvitamin D acute respiratory syndrome adaptive amplification Analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 mortality creatinine Critical cytoplasm dead dead patient erythrocyte sedimentation rate ESR evaluate Factors Genetic Genotype genotyped Host IFITM3 Impact increased mortality indicated innate immune response Interferon-induced transmembrane protein 3 liver enzymes membrane minor allele frequency Mortality multivariate logistic regression Mutation parameters Patient PCR polymorphism positive profiles required Result SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 significantly more suggested transmembrane protein uric acid viral cell [DOI] 10.1016/j.cyto.2022.155957 [Article Type] Research article