Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2Imatinib의 전임상 평가는 SARS-CoV-2에 대한 항바이러스제로 사용을 지지하지 않습니다.Article Published on 2021-09-012022-09-11 Journal: Antiviral Research [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral activity antiviral drug antivirals clinical trial clinical trials Concentration coronavirus COVID-19 described drugs effective evaluated Hematological malignancies Human airway epithelium Imatinib impair inactive indicated initiated Kinase inhibitor kinase inhibitors lung masitinib pathogenic coronaviruses plasma Preclinical reconstructed Safe SARS-CoV-2 SARS-CoV-2 replication Support therapy TKI TKIs Treatment tyrosine tyrosine kinase inhibitor VeroE6 cells [DOI] 10.1016/j.antiviral.2021.105137 PMC 바로가기 [Article Type] Article
The serological prevalence of SARS‐CoV‐2 infection in patients with chronic myeloid leukemia is similar to that in the general population만성 골수성 백혈병 환자에서 SARS-CoV-2 감염의 혈청학적 유병률은 일반 인구와 유사합니다.Research Article Published on 2021-08-312022-09-12 Journal: Cancer Medicine [Category] MERS, SARS, 진단, [키워드] adverse outcome Antibody Response antibody response against association Asymptomatic chronic myeloid leukemia CML conducted consecutive patient Course COVID‐19 COVID‐19 disease Evidence FIVE General population generally mild hematologic Hematological malignancy IgG/IgM antibody increased risk Italian regions Italy leukemia male mild symptoms Molecular diagnosis mortality rate National pandemic Patient positive Preclinical Prevalence protective role reported Result SARS‐CoV‐2 SARS‐CoV‐2 infection serological Serological tests tested TKI TKIs Treatment tyrosine kinase inhibitor [DOI] 10.1002/cam4.4179 PMC 바로가기 [Article Type] Research Article
Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease SettingsNeurology Published on 2021-08-172022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] Adults auditory Baseline assessment cell line cell lines Chloroquine clinical trials Compound conditions COVID-19 COVID-19 therapeutics database drug Effects effort elderly patients etiology evaluate Factor FDA-approved drug genetic polymorphisms hallmark hearing loss identify in silico in vitro in vivo induce Inflammation lack Lopinavir-ritonavir mammalian Medicines novel novel ototoxins offer ototoxic ototoxicity over pandemic Patient potentiation Preclinical Screening setting Side-effect similarity subset synergy Therapeutic treatment Therapies therapy treat treating COVID-19 Validity variety zebrafish [DOI] 10.3389/fneur.2021.725566 PMC 바로가기 [Article Type] Neurology
Editorial: Post-Exposure Prophylactic Neutralizing Monoclonal Antibodies to SARS-CoV-2 for Individuals at High Risk for COVID-19사설: COVID-19 고위험군 개인을 위한 SARS-CoV-2에 대한 노출 후 예방 중화 단일클론 항체Editorial Published on 2021-08-162022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 변종, 진단, [키워드] accelerated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approval approvals approved authorization bamlanivimab Casirivimab children clinical development Clinical studies clinical study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression diagnostic drug editorial Effectiveness Emergency Emergency use Emergency use authorization etesevimab EUA exposure to FDA food high risk Imdevimab individual initial Mild mild to moderate Moderate COVID-19 monoclonal antibody monotherapy Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody Older pandemic Preclinical Prevent progression Prophylactic REGEN-COV Regulatory Regulatory Authorities respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 therapeutic therapy treat US Food and Drug Administration Vaccine variants of SARS-CoV-2 [DOI] 10.12659/MSM.934393 PMC 바로가기 [Article Type] Editorial
Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2Review Published on 2021-07-312022-11-01 Journal: Foods [Category] COVID-19, [키워드] 3CL pro ACE2 acute respiratory syndrome addition amino acid residue angiotensin-converting enzyme 2 Anti-inflammatory anticancer antioxidant Antiviral antiviral properties binding affinity Characteristics Chemical chemical constituents clinical Clinical applications component coronavirus COVID-19 demonstrated derivative dietary supplement distribution Diversity drug-likeness effective Efficacy Helicase herpes simplex high affinity HIV HSV-1 Human immunodeficiency virus Hydrogen bond immunomodulatory influenza viruses measure metabolism modulating molecular docking Molecular docking study over Papain-like protease parameters pathogenic Pathways Potential Preclinical produced property Propolis protease RBD RdRP respiratory tract RNA-dependent RNA polymerase S-protein SARS-CoV-2 SARS-CoV-2 proteins shown Support target proteins the receptor-binding domain the spike protein therapeutic these compounds Toxicity viral entry virus viruses [DOI] 10.3390/foods10081776 PMC 바로가기 [Article Type] Review
Are We Paving the Way to Dig Out of the “Pandemic Hole”? A Narrative Review on SARS-CoV-2 Vaccination: From Animal Models to Human Immunization우리는 "팬데믹 홀"을 파헤치기 위한 길을 닦고 있습니까? SARS-CoV-2 백신 접종에 대한 내러티브 검토: 동물 모델에서 인간 예방 접종까지Review Published on 2021-07-302022-09-10 Journal: Medical Sciences [Category] 비임상, 임상, [키워드] acute respiratory syndrome animal animal model animal models approach breath Clinical studies clinical study clinical trial clinical trials company contributed coronavirus coronavirus 2 COVID-19 develop effective vaccine extreme Government herd immunity high mortality rate Human human immunization humans immune responses Immunity immunization Inactivated Vaccines induce Infectious disease International mechanism Model morbidity and mortality narrative pandemic pathogen Preclinical preclinical studies preclinical study Prevent Protective provide Research respiratory review robust Safe SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spectrum therapeutic intervention therapeutic interventions Vaccination strategies Vaccine Vaccines Viral Viral vector vaccines virus [DOI] 10.3390/medsci9030053 PMC 바로가기 [Article Type] Review
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics SummitArticle Published on 2021-07-152023-07-01 Journal: The Journal of Infectious Diseases [Category] SARS, [키워드] antiviral therapeutics emerging modalities Preclinical Proteases SARS-CoV-2 viral replication machinery [DOI] 10.1093/infdis/jiab305 PMC 바로가기
Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial Research Published on 2021-07-082022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, [키워드] Administered Algorithm Analysis baseline change Clinical data conducted confidence interval double-blind Efficacy fat FGF21 fibroblast fibrosis FIVE fraction fusion protein group groups growth factor hepatic fat IMPROVE majority NASH Patient patients Placebo placebo-controlled placebo-controlled study Preclinical Randomized receive reduced reported safety profile significantly statistically significant difference steatohepatitis stratified study drug subcutaneous injection TEAE the placebo group the United State treat Treatment treatment-emergent adverse event Trial [DOI] 10.1038/s41591-021-01425-3 [Article Type] Research
Making the COVID-19 Pandemic a Driver for Digital Health: Brazilian StrategiesViewpoint Published on 2021-06-292022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, [키워드] access applied assist Brazil Care caused clinical outcomes concerning Contact COVID-19 COVID-19 outbreak creating data Department Digital Digital health digital technology expected facilitated faster Giant Health health data health system hospital implementation informatics information Intention involved Making Medical informatics monitoring network Occurrence outbreak pandemic platform Preclinical Prevent problem professional public health reduction Safe SARS-CoV-2 Strategy SUS System the patient virus website [DOI] 10.2196/28643 PMC 바로가기 [Article Type] Viewpoint
Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and AuthorizationTozinameran (BNT162B2) 백신 : 전임상 연구에서 임상 시험 및 승인으로의 여정Review Published on 2021-06-072022-08-31 Journal: AAPS PharmSciTech [Category] MERS, SARS, 신약개발, 임상, 진단, [키워드] Administered administration adolescents adverse effects age antibody Antibody Response authorization bind BioNTech BNT162b1 BNT162b2 BNT162b2 vaccine BNT162b2 vaccines children clinical clinical trial clinical trials COVID-19 dosages Efficacy ENCODE EUA exhibited expected expression first dose host cells immune response Immunity individual Lipid nanoparticle Lipid nanoparticles mRNA Neutralizing antibodies of BNT162b2 Older operation participant Pfizer Pfizer-BioNTech Phase 1 phase 1 trials phase 1/2 trials Phase 2 phase 2 trials phase 2/ 3 trials phase 2/3 Phase 3 Phase 3 trials Preclinical preclinical studies preclinical trials pregnant pregnant women question real-world outcomes receive reported RNA robust S antigen Safety SARS-CoV-2 SARS-CoV-2 spike protein speed Spike protein Support the SARS-CoV-2 Tozinameran transfer Trial Vaccine [DOI] 10.1208/s12249-021-02058-y PMC 바로가기 [Article Type] Review