Intranasal vaccination of hamsters with a Newcastle disease virus vector expressing the S1 subunit protects animals against SARS-CoV-2 diseaseS1 소단위를 발현하는 뉴캐슬병 바이러스 벡터를 사용한 햄스터의 비강내 예방접종은 SARS-CoV-2 질병으로부터 동물을 보호합니다Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administer administration animals breath claimed coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical effective Efficacy elicited expressing hamster hamsters human clinical trial humoral immune responses immune responses long term lung damage mice Neutralizing antibodies newcastle disease virus pandemic phase prevented PROTECT Protective recent recorded recorded history reduced respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 disease severe acute respiratory syndrome Coronavirus short term significantly the disease the S1 subunit vaccination Vaccine vaccine candidate variant vectored vaccine Viral Viral load while [DOI] 10.1038/s41598-022-13560-z PMC 바로가기 [Article Type] Article
Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infectionMVA 기반 백신의 비강내 접종은 IgA를 유도하고 SARS-CoV-2 감염으로부터 hACE2 마우스의 호흡기를 보호합니다Article Published on 2022-06-142022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome administration Antigen Beta Blood CD3 CD8 coronavirus coronavirus 2 coronavirus vaccine COVID-19 COVID-19 pandemic current effective expressing firefly luciferase hACE2 IFN-γ IgA IgG immune responses Immunity immunized Immunoglobulin immunoglobulin A Immunoglobulin G induce Infection Infectious virus intramuscular intramuscular vaccination intramuscularly intranasal intranasally K18-hACE2 less luciferase Luminescence lung Lungs mice modified vaccinia virus morbidity mucosal mucosal immunity nasal turbinate nasal turbinates neutralized Neutralizing antibodies neutralizing antibody omicron Prevent prevented priming PROTECT protective immune response pseudovirus pseudoviruses raise remained respiratory respiratory immunity respiratory tract S protein S proteins SARS-CoV-2 SARS-COV-2 infection serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity T cells the S protein Transmission upper respiratory tract vaccination Vaccine vaccinia virus variants Viral while Wuhan [DOI] 10.1073/pnas.2202069119 PMC 바로가기 [Article Type] Article
Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vesselsArticle Published on 2022-06-132022-10-04 Journal: Cellular and Molecular Life Sciences [Category] COVID19(2023년), SARS, 신약개발, [키워드] ACE2 acute phase Analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels [DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2전신 중화 항체와 국소 면역 반응은 SARS-CoV-2의 통제에 중요합니다Article Published on 2022-06-102022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration approved Brain cell-mediated immune response complex Control Correlate of protection COVID-19 COVID-19 vaccines Critical dissemination DNA Efficacy elicited heterologous vaccine humoral humoral responses immune response immunization immunogenic intramuscular intranasal Local lung mucosal mucosal immunity nanovaccine Neutralizing Parenteral Plasmid prevented Protective reduced response SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S serum systemic T-cell immune response transgenic mice used to evaluate Vaccine viral burden viral replication [DOI] 10.3390/v14061262 PMC 바로가기 [Article Type] Article
Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus [DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells당뇨병 환경은 인간 신장 오르가노이드 및 환자 세포에서 SARS-CoV-2 감염에 대한 ACE2 발현 및 세포 감수성을 증가시킵니다Article Published on 2022-06-072022-09-11 Journal: Cell Metabolism [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression aerobic aerobic glycolysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsy Cell cells cellular condition COVID-19 COVID-19 pathogenesis Critical develop diabete diabetes diabetes 2 Diabetic diabetic kidney diabetic patient diabetic patients dichloroacetate door energy metabolism enzyme exhibited Glycolysis hallmark human kidney human kidney organoids. increase individual inhibitor Intervention kidney Kidney disease kidney organoid kidney organoids metabolism mitochondrial Organoid organoids Patient prevented programming reduced resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 susceptibility Viral detection Viral load [DOI] 10.1016/j.cmet.2022.04.009 PMC 바로가기 [Article Type] Article
NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis Research Published on 2022-06-062022-10-05 Journal: Nature nanotechnology [Category] 바이오마커, [키워드] addition Apoptosis approach Bacteremia Cell cells cellular death demonstrated help homoeostasis immune immunomodulator Infection Inflammation key factor life-threatening maintain modulating multidrug-resistant multiorgan injury NAD+ NADH organ dysfunction outcome Pathogenesis prevented Pseudomonas aeruginosa pyroptosis reduced responsible Sepsis suppressed the United State therapeutic efficacy therapy translational Transport treat Vascular function vascular homeostasis [DOI] 10.1038/s41565-022-01137-w [Article Type] Research
Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulationArticle Published on 2022-06-012022-10-04 Journal: Photochemical & photobiological sciences : Official journal of the European [Category] COVID19(2023년), SARS, 신약개발, [키워드] amplification amplitude antimicrobial Antimicrobial photodynamic disinfection approved clinical sample Clinical use collected Concentration condition coronavirus disease COVID-19 COVID-19 patients cytotoxicity early stage exhibiting form global effort HEK293T cells infect Infection lentiviral luciferase reporter gene medical need Medicines Methylene Methylene blue nasal pandemic PDI photodisinfection photodynamic inactivation prevented pseudotyped Pseudotyped lentiviral vector reduce SARS-CoV-2 severity the disease the S protein Transmission Treatment urgency Viral load [DOI] 10.1007/s43630-022-00202-6 PMC 바로가기 [Article Type] Article
Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaquesResearch article Published on 2022-05-252022-10-05 Journal: iScience [Category] 비임상, [키워드] blunting cells clinical trials decrease explain FIVE Hospitalization hospitalized patient increases in Infection innate immune response intensity lung lung damage lung viral load Lungs mathematical modeling Molecular modeling nasal nasal passage nasal passages occur Pneumonia prevented raise reducing reduction in Remdesivir rhesus macaque rhesus macaques SARS- CoV-2 SARS-CoV-2 shedding relative therapy Viral load viral loads Virology [DOI] 10.1016/j.isci.2022.104448 [Article Type] Research article