Safety and immunogenicity of a recombinant tandem-repeat dimeric RBD-based protein subunit vaccine (ZF2001) against COVID-19 in adults: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials성인에서 COVID-19에 대한 재조합 직렬 반복 이량체 RBD 기반 단백질 서브유닛 백신(ZF2001)의 안전성 및 면역원성: 2건의 무작위 배정, 이중 맹검, 위약 대조, 1상 및 2상 시험Clinical Trial Published on 2021-08-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상, 진단, [키워드] 95% CI Abstract Academy adverse event age allergy antibodies Antigen appear assigned Beijing biopharmaceutical center China Chinese Chongqing Contact Control COVID-19 COVID-19 cases COVID-19 vaccine determine development dimeric dose double-blind drug Efficacy eligible enrolled enrolment FIVE Follow-up geometric mean titre GMT group help immunogenic immunogenicity data intention-to-treat intramuscularly Laboratory magnitude Major material mechanism Mild moderate neutralising antibody Occurrence participant Participants per-protocol Phase 1 phase 1 trial phase 2 trial phase 3 trial Placebo placebo group placebo-controlled prevention Primary outcome priority Program protein subunit vaccine randomised Randomly RBD RBD-based protein subunit receive Registered reported Safety SARS-CoV SARS-CoV-2 SARS-COV-2 infection Science second dose Serious Adverse Event Serious Adverse Events seroconversion rate Seven Spike protein Spread Support technology the placebo group the receptor-binding domain the SARS-CoV-2 the vaccine translation Trial trials university hospital vaccination Vaccine vaccine group Vaccines was done ZF2001 [DOI] 10.1016/S1473-3099(21)00127-4 PMC 바로가기 [Article Type] Clinical Trial
[COVID-19 outbreak investigation in a geriatric palliative hospital][노인요양병원 코로나19 발생 조사]Article Published on 2021-08-012022-09-11 Journal: Zeitschrift Fur Gerontologie Und Geriatrie [Category] SARS, 치료기술, [키워드] 95 % CI Asymptomatic close contact Compliance Contact contact with coronavirus counteract COVID COVID-19 COVID-19 outbreak described disease outbreak dropped effective English equipment Factor Geriatrics hcp Health Health personnel Health policy healthcare personnel hospital hygiene Infection less Masks material measure median Nosocomial infection Nosocomial infections occupancy rate outbreak Outbreak investigation Palliative care Patient patients patients died PCR positive PCR-positive Personal protective equipment positive positive patient positive patients potential risk preventive intervention preventive interventions priority Protective remained risk factor Risk factors strict hygiene measures Tage vaccination vulnerability [DOI] 10.1007/s00391-021-01930-7 PMC 바로가기 [Article Type] Article
Impact on polytrauma patient prehospital care during the first wave of the COVID-19 pandemic: a cross-sectional studyOriginal Article Published on 2021-07-302022-11-01 Journal: European Journal of Trauma and Emergency Surgery [Category] COVID-19, MERS, SARS, [키워드] Activation affected Analysis assigned burns Care caused Characteristics clinical variable code conducted COVID-19 COVID-19 pandemic cross-sectional decrease determine Emergency epidemiological First wave Hospital mortality Impact increase in Injury Logistic regression Nonparametric tests objective pandemic pathology Patient patients Polytrauma prehospital presenting priority remained representing respond Result SARS-CoV-2 severity study period Support System Timely life-saving interventions treated [DOI] 10.1007/s00068-021-01748-3 PMC 바로가기 [Article Type] Original Article
Introducing and Implementing HIV Self-Testing in Côte d’Ivoire, Mali, and Senegal: What Can We Learn From ATLAS Project Activity Reports in the Context of the COVID-19 Crisis?Public Health Published on 2021-07-202022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, SARS, [키워드] activities activity average Côte d'Ivoire Can changes in collected Contact Context country COVID-19 COVID-19 pandemic decrease distribution drug emergency response Evolution focus group Health HIV HIV self-testing hygiene impacted implementation Implementing include increase in information initial investigated key populations less Mali management Measures men peer Population populations priority promote Quantitative reducing report Resilience secondary Senegal Sex Variation West Africa [DOI] 10.3389/fpubh.2021.653565 PMC 바로가기 [Article Type] Public Health
Non-communicable Disease Surveillance in Malaysia: An Overview of Existing Systems and Priorities Going ForwardPublic Health Published on 2021-07-062022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] activity analyzed conducted country COVID-19 pandemic Forward framework health system health systems highlight include lack Malaysia member mental health monitoring Mortality National nine Non-communicable disease outcome Policy priority public health reduction robust state Surveillance System targets the WHO WHO World Health Organization [DOI] 10.3389/fpubh.2021.698741 PMC 바로가기 [Article Type] Public Health
COVID-19 vaccination in pregnant and lactating diabetic women임산부와 수유부 당뇨병 여성의 코로나19 예방접종Article Published on 2021-06-302022-09-11 Journal: Nutrition, metabolism, and cardiovascular diseases [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Admission adverse outcomes affected association baby BMI body mass body mass index breastmilk circulation clinical trial clinical trials Comorbidity complications Course COVD-19 COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines diabete diabetes Diabetes Mellitus Diabetes mellitus type 1 Diabetes mellitus type 2 Diabetic direct association during pregnancy Efficacy excluded fetal fetus Gestational diabetes glycol high risk IgG immunization Infection Infection prevention information intensive care intensive care unit lactating lactating women mother Neonatal Neonate Neonates Newborn obese obese patient obesity outcome passive immunization Pregnancy pregnant pregnant women preterm delivery priority PROTECT protective antibodies Protective antibody receive reported respiratory SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 transplacental passage vaccination Vaccine Vaccines with COVID-19 women worse prognosis [DOI] 10.1016/j.numecd.2021.04.012 PMC 바로가기 [Article Type] Article
Children and Adolescent Mental Health in a Time of COVID-19: A Forgotten PriorityViewpoint Published on 2021-06-292022-10-27 Journal: Annals of Global Health [Category] Coronavirus, MERS, SARS, [키워드] Adolescent affected Anxiety Care children Community consequence COVID-19 death Depression early diagnosis Effect Evidence highlight impacted Intervention lockdowns Measures mental health mental health condition mental health conditions pandemic physically priority Psychological receive restrict shown significantly Support time Treatment [DOI] 10.5334/aogh.3330 PMC 바로가기 [Article Type] Viewpoint
COVID-19 Preparedness and Response: Validation of a Rapid Assessment Tool to Evaluate Priorities of Health Workers at the Grassroots LevelPublic Health Published on 2021-06-292022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] assessment blind Community conducted COVID-19 COVID-19 outbreak cross-sectional demonstrated disease effective evaluate evaluated Government groups Health health worker health workers healthcare highest implementation initial International iteration Level limitation Local measure medical student National priority professional public health public health measures Rapid recommendation response setting priority Support validation Validity Vietnam worker [DOI] 10.3389/fpubh.2021.562600 PMC 바로가기 [Article Type] Public Health
Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead OptimizationCovid-19 치료를위한 일부 NSAID의 잠재력에 대한 계산 통찰력 : 우선 순위 세트 및 리드 최적화Article Published on 2021-06-212022-08-31 Journal: Molecules [Category] MERS, SARS, 신약개발, 치료제, [키워드] addition antagonist anti-inflammatory activity anti-inflammatory effect auranofin candidate carried caused Compound compounds conducted COVID-19 cytokine DFT calculations docking drug Drug repurposing effective evaluated expected FDA-approved drug FDA-approved drugs functional Health help indomethacin Inflammation Inflammatory cytokine Inflammatory cytokine storm inhibiting inhibitor inhibitors insight lead lung damage M pro molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations NSAID NSAIDS optimization pandemic parameter Potential priority protease provide provoking responsible resulting Safe SAR SARS-CoV-2 SARS-CoV-2 main protease screened severity sulfinpyrazone target receptor tested therapeutic treating Treatment treatment for COVID-19 [DOI] 10.3390/molecules26123772 PMC 바로가기 [Article Type] Article
Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trialCOVID-19의 외래 환자 치료로서 하이드록시클로로퀸의 효능 및 안전성 평가: 무작위 대조 시험Randomized Controlled Trial Published on 2021-06-182022-09-11 Journal: CMAJ open [Category] SARS, 임상, 치료제, [키워드] 95% confidence interval Assessing assigned Chain Reaction Community Composite conducted Contact contact with Controlled trial COVID-19 COVID-19 pandemic death determine determined by did not reduce direct contact disposition effect of treatment Efficacy and safety eligible enrolment Evidence expected First wave Follow-up hazard ratio Hospitalization hospitalizations hospitalized patient hospitalized patients Hydroxychloroquine hydroxychloroquine group hydroxychloroquine treatment identification individual Invasive mechanical ventilation matching placebo mechanical ventilation Mortality outcome outcomes Outpatient outpatients participant Participants patients PCR test Placebo placebo group polymerase chain polymerase chain reaction positive RT-PCR Prevent prevented Primary outcome priority raised Randomized controlled trial Randomly reduced resulting reverse transcription reverse transcription polymerase chain reaction Ribonucleic acid RT-PCR Safety SARS-COV-2 infection secondary Secondary outcomes Serious Adverse Event Serious Adverse Events severe COVID-19 study drug survived symptom duration symptom onset the placebo group therapy Treatment Trial viral ribonucleic acid with COVID-19 [DOI] 10.9778/cmajo.20210069 PMC 바로가기 [Article Type] Randomized Controlled Trial