Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M Pro inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Research Note Published on 2020-11-112022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acceptor acute respiratory syndrome antiviral drugs approach binding site bond Chloroquine complex coronavirus Coronavirus-2 COVID-19 derivative derivatives evaluate Favipiravir feature hydrogen Hydroxychloroquine inhibition activity inhibitor inhibitors Interaction interactions monolaurin objective performed pharmacophore pharmacophore modelling Pro Remdesivir Result Ritonavir SARS-CoV-2 Tetrodotoxin Vanillin were used [DOI] 10.1186/s13104-020-05379-6 PMC 바로가기 [Article Type] Research Note
Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M Pro inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Research Note Published on 2020-11-112022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, SARS, [키워드] acceptor acute respiratory syndrome antiviral drugs approach binding site bond Chloroquine complex coronavirus Coronavirus-2 COVID-19 derivative derivatives evaluate Favipiravir feature hydrogen Hydroxychloroquine inhibition activity inhibitor inhibitors Interaction interactions monolaurin objective performed pharmacophore pharmacophore modelling Pro Remdesivir Result Ritonavir SARS-CoV-2 Tetrodotoxin Vanillin were used [DOI] 10.1186/s13104-020-05379-6 PMC 바로가기 [Article Type] Research Note
Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and ConsReview Article Published on 2020-10-102022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] acute respiratory syndrome addition Antiviral candidate caused Cinchona clinical trial Compound conducted coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patients Curcuma drug candidate Echinacea effective evaluate the effect experiments Factor Herbal immune regulation immunomodulator immunomodulators Impaired Infectious disease Medicine outcome pandemic Pathogenesis plants Prevent Pro recommendation reported review SARS-CoV-2 significantly the disease Traditional Treatment [DOI] 10.1155/2020/2560645 PMC 바로가기 [Article Type] Review Article
Pro- and Anti-Inflammatory Responses in Severe COVID-19-Induced Acute Respiratory Distress Syndrome—An Observational Pilot StudyImmunology Published on 2020-10-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome analyzed Anti-inflammatory anti-inflammatory cytokine antibody production Antibody Response ARDS B cell B cell response CD8+ CD8+ T cells cellular response characterized collected coronavirus 2 Coronavirus disease 2019 COVID-19 Cytokine analysis Cytokines decrease died elevated flow-cytometry growth growth differentiation factor 15 ICU ICU treatment IgM IL-10 IL-6 immune defense immune response Immunoglobulin Inflammation intensive care Interaction interleukin longitudinal Lymphocyte count Lymphocyte subsets lymphocytopenia mechanism naïve natural killer NK cell objective Patient Pro Protein RBD Receptor binding domain Resilience respiratory response Result Retrospective study routine clinical care SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe ARDS severity single-center slight increase spike suffered syndrome T helper cells tissue upregulated [DOI] 10.3389/fimmu.2020.581338 PMC 바로가기 [Article Type] Immunology
Severe Coronavirus disease 2019 pneumonia patients showed signs of aggravated renal impairmentResearch Article Published on 2020-08-252022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, MERS, SARS, [키워드] acid acute respiratory syndrome biological marker C‐reactive protein Clinical Center collected Concentration coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 patient COVID‐19 CREA creatinine erythrocyte sedimentation ESR female FIVE hs‐CRP identify indicated Infection Inflammatory response Kidney function male Mild Patient PCT Pneumonia Pro procalcitonin Protein public health renal impairment Result Sample SARS‐CoV‐2 sensitive indicator serum severe group Severe patient severe patients Shanghai significant difference tested UA urea Urine urine protein [DOI] 10.1002/jcla.23535 PMC 바로가기 [Article Type] Research Article
Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2Short Report Published on 2020-07-102022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] Analysis antigenicity B-cell epitope B-cell epitopes BepiPred binding bioinformatics Bioinformatics analysis Biotechnology candidate caused center characterized component computation database Discontinuous epitope Epitope-based vaccine exhibited feature genome sequence Gln HLA binding IEDB immune Infection MHC class MHC class I NCBI nucleocapsid protein outbreak pandemic peptide predict predicted Pro produced Protective protein sequence public health Rapid residue resource Result retrieved SARS-CoV-2 spike Spike protein surface T-cell epitope Thr Vaccine Vaccine development [DOI] 10.1186/s40249-020-00713-3 PMC 바로가기 [Article Type] Short Report
Employing bioactive compounds derived from Ipomoea obscura (L.) to evaluate potential inhibitor for SARS‐CoV‐2 main protease and ACE2 proteinResearch Article Published on 2020-07-062022-10-31 Journal: Food Frontiers [Category] COVID-19, [키워드] Ipomoea Obscura (L.) ACE2 ACE2 protein ADME Analysis angiotensin converting enzyme Antiviral effect Compound determine evaluate exhibit GC‐MS Genome host cell host cells inhibitor inhibitory activity involved Ipomoea molecular docking Molecular docking study Pro protease Replication Result SARS‐CoV‐2 SARS‐CoV‐2 suggested target protein target proteins viral genome viral replication [DOI] 10.1002/fft2.29 PMC 바로가기 [Article Type] Research Article
Pros and cons of the application of evolutionary theories to the evolution of SARS-CoV-2Special Report Published on 2020-04-172022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acute respiratory syndrome application caused Concerns confounding factor coronavirus Evolution evolution and origin Evolution of SARS-CoV-2 genetics hosts outbreak Pro raised Replication RNA RNA modification RNA virus RNA viruses SARS-CoV-2 Support the SARS-CoV-2 Validity [DOI] 10.2217/fvl-2020-0048 PMC 바로가기 [Article Type] Special Report