Effectiveness of anakinra for tocilizumab-refractory severe COVID-19: A single-centre retrospective comparative study토실리주맙-불응성 중증 COVID-19에 대한 아나킨라의 효과: 단일 센터 후향적 비교 연구Comparative Study Published on 2021-04-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] 1:1 age Anakinra baseline Clinical improvement clinical status cohort of patient Comorbidities Control control group COVID-19 COVID-19 disease Cytokine release syndrome determine elapsed Follow-up fraction immunomodulation in-hospital mortality rate initiation of treatment males outcome oxygen oxygen saturation Patient patients with COVID-19 Pneumonia Primary outcome prognosis of patient prospective cohort pulse oximetry receiving retrospective SARS-COV-2 infection selected severe COVID-19 SpO2/FiO2 subgroup of patient therapy thought Tocilizumab treated Treatment [DOI] 10.1016/j.ijid.2021.02.041 PMC 바로가기 [Article Type] Comparative Study
Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in ChinaObservational Study Published on 2021-03-072022-10-05 Journal: World journal of gastroenterology [Category] 임상, [키워드] 95% confidence interval alanine aminotransferase Antibiotics Aspartate aminotransferase China Clinical features collected Comorbidities consecutive patient coronavirus disease COVID-19 COVID-19 patients Critical D-dimer disease severity drug drugs effective elevated Factors Female patients IMPROVE increased mortality increased the risk independent risk factor indicated Injury Intensive intravenous Laboratory parameters Liver injury Lymphocyte count measure medications mortality risk occurred Patient Prevent Prognosis prognosis of patient Progressive retrospective cohort study risk risk factor Risk factors Serum ferritin severe COVID-19 subsequent Tongji Hospital total bilirubin treat was performed Wuhan, China [DOI] 10.3748/wjg.v27.i9.835 PMC 바로가기 [Article Type] Observational Study
Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units페리틴은 폐 침범의 심각성과 관련이 있지만 COVID-19 환자의 더 나쁜 예후와는 관련이 없습니다: 2개의 이탈리아 COVID-19 유닛의 데이터Clinical Trial Published on 2021-03-012022-08-13 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 95% CI Abruzzo Admission age and gender Biomarker Care clinical clinical decision Clinical sign Clinical signs complex Computed tomography conducted coronavirus coronavirus 2019 disease Course covariate covariates COVID-19 CT scan death Deceased demonstrated discharged disease disease severity enrolled evaluated feature female ferritin ferritin level ferritin levels help heterogeneous hospital hospitalized patient hospitalized patients identify investigated Italian Italy Logistic regression analysis lung abnormalities lung abnormality lung involvement lymph node enlargement males median age mediastinal lymph node mediastinal lymph node enlargement no differences occurred outcome outcomes pathophysiology Patient patients patients with COVID-19 Prognosis prognosis of patient pulmonary involvement pulmonary lobe pulmonary lobes regression analysis retrospective SARS-CoV-2 SARS-COV-2 infection septal thickening serological severe pulmonary involvement severity Therapeutic approach therapeutic approaches unit worse prognosis [DOI] 10.1038/s41598-021-83831-8 PMC 바로가기 [Article Type] Clinical Trial
Prediction of COVID-19 severity using laboratory findings on admission: informative values, thresholds, ML model performance입원 시 실험실 결과를 사용한 COVID-19 심각도 예측: 유익한 값, 임계값, ML 모델 성능Article Published on 2021-02-262022-08-31 Journal: BMJ Open [Category] MERS, 바이오마커, [키워드] 95% CI activated activated partial thromboplastin time admitted to ICU Alanine alanine aminotransferase Algorithm aPTT aspartate Aspartate aminotransferase AUC Bilirubin Biochemistry bioinformatics Biomarker Biotechnology biotechnology & C reactive protein Clinical use comparable consecutive patient COVID-19 COVID-19 severity creatine creatine kinase CRP cut-off cut-off threshold D-dimer dataset Deterioration disease severity disproportion Dubai Features ferritin fibrinogen Free ICU identify Infectious diseases information information technology intensive care intensive care unit Laboratory Laboratory test Laboratory tests Lactate lactate dehydrogenase lymphocyte Lymphocyte count ML model non-severe cases online tool partial thromboplastin time Patient PCR predict prediction Predictive Prognosis prognosis of patient respiratory respiratory infections returned risk Stratification study cohort subjects threshold threshold value thresholds THROMBOPLASTIN total bilirubin troponin with COVID-19 worsening [DOI] 10.1136/bmjopen-2020-044500 PMC 바로가기 [Article Type] Article
Development and validation of a prognostic model based on comorbidities to predict COVID-19 severity: a population-based studyCovid-19 Published on 2021-02-082022-10-30 Journal: International Journal of Epidemiology [Category] COVID-19, SARS, [키워드] 95%CI Admission admission to ICU age Asthma calibration cardiovascular disease Chronic kidney disease chronic obstructive classification clinician Comorbidity confidence interval COVID-19 COVID-19 patients death demonstrated development diabetes died disease severity Electronic health record estimate evaluated facilitate Gender Haematological cancer health authorities help high-risk patient Hospitalization hypertension ICU incidence Infection intensive care Liver disease Mortality obesity Patient patients patients with COVID-19 polymerase chain predict Prediction model Probability prognosis of patient prognostic model progression pulmonary disease receiver operating characteristics Regression model required Result retrospective cohort study reverse transcription risk ROC RT-PCR severity Sex Spain variable were used with COVID-19 [DOI] 10.1093/ije/dyaa209 PMC 바로가기 [Article Type] Covid-19
Effect of antitumor therapy on cancer patients infected by SARS‐CoV‐2: A systematic review and meta‐analysisOriginal Research Published on 2021-02-062022-10-31 Journal: Cancer Medicine [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% CIs 95% confidence interval acute respiratory syndrome antitumor therapy Cancer cancer patient Chemotherapy Chinese CNKI Cochrane Library conducted coronavirus COVID‐19 COVID‐19 patients COVID‐19 death develop Effect evaluated event Evidence high mortality high risk incidence Infrastructure medRxiv meta‐analysis Mortality no significant difference pandemic Patient Prognosis prognosis of patient random effect receive Result SARS‐CoV‐2 severe group severe symptom significant difference survival group symptom onset systematic literature search systematic review therapy Treatment [DOI] 10.1002/cam4.3754 PMC 바로가기 [Article Type] Original Research
Impact of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on COVID-19 in a western population. CARDIOVID registryObservational Study Published on 2021-02-012022-10-05 Journal: Revista española de cardiología (English ed.) [Category] 임상, [키워드] 95%CI ACEi acute cardiovascular event adjusted Admission Affect angiotensin angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors Antagonistas del receptor de la angiotensina II ARB clinical implication coronavirus COVID-19 COVID-19 patients diagnosed with COVID-19 Diagnosis disease English enzyme evaluate global pandemic Government had no Health heart failure Hospitalization ICU admission Impact Infection Inhibidores de la enzima de conversión de la angiotensina. intensive care Mortality multivariate logistic regression Neutral Observational cohort study outcome Pandemia Patient patients with COVID-19 positive Prognosis prognosis of patient propensity score matching receptor recommendation remained retrospective Spanish subgroup analysis total population Treatment with COVID-19 World Health Organization [DOI] 10.1016/j.rec.2020.05.018 PMC 바로가기 [Article Type] Observational Study
Machine learning model for predicting severity prognosis in patients infected with COVID-19: Study protocol from COVID-AI BrasilRegistered Report Protocol Published on 2021-02-012022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Algorithm alternative hypothesis AUC beta coronavirus Chest computed tomography Chest CT China Clinical sign collected Course COVID-19 COVID-19 infection develop development discomfort dysfunction epidemiological epidemiological data epidemiological history evaluate exclusion criteria expected Factor hospital Hypotension identify include Inclusion individual infected with COVID-19 Length machine Metrics multicenter New coronavirus outcome outcomes Patient patients performed positive predict Prognosis prognosis of patient prognostic Prognostic factors protocol radiological respiratory retrospective RNA SARS-CoV-2 secondary secondary outcome severity single-stranded Symptom syndrome the disease time Vasopressor Wuhan [DOI] 10.1371/journal.pone.0245384 PMC 바로가기 [Article Type] Registered Report Protocol
The Novel Perspectives Opened by ST2 in the Pandemic: A Review of Its Role in the Diagnosis and Prognosis of Patients with Heart Failure and COVID-19Review Published on 2021-01-262022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Biomarker cardiovascular comorbidity clinical manifestation connection coronavirus disease Course COVID-19 detectable early diagnosis Effects Evidence Evolution failure fibrosis heart heart failure incidence independent Inflammation isoform Local marker Mortality Multiple Myocardial myocardial injury novel Opened outcome pathway Patient patients with COVID-19 Perspective Prognosis prognosis of patient Prognostic factor public health systems review risk stratification role serum severity ST2 suggested suppression systemic inflammation transmembrane [DOI] 10.3390/diagnostics11020175 PMC 바로가기 [Article Type] Review
The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patientsArticle Published on 2021-01-192022-10-04 Journal: Scientific Reports [Category] MERS, 치료기술, 치료법, [키워드] addition advanced age age AUC Biomarkers can be used Clinical outcome COVID-19 COVID-19 patient COVID-19 patients Critically ill patient Cutoff D-dimer D-dimer level D-dimer levels D-dimer value death died Diseases Dyspnea evaluate examined Factor Factors Gender hospital Impact lab male Mild mortality risk outcome Patient Peripheral blood poor prognosis Probability Prognosis prognosis of patient prognosis of patients ROC analysis significantly higher surviving patient Symptoms underlying disease with COVID-19 Wuhan, China [DOI] 10.1038/s41598-021-81300-w PMC 바로가기 [Article Type] Article