Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study코로나바이러스 질병-2019에 대한 치료용 혈장 교환은 사이토카인 방출 증후군을 유발했습니다. 후향적 성향 일치 대조 연구Research Article Published on 2021-01-072022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] 1:1 95% CI Analysis analyzed assigned both groups Cohort Control controls coronavirus coronavirus disease coronavirus disease-2019 COVID-19 Critical CRS cytokine cytokine release Cytokine release syndrome Cytokines discharge disease severity duration of hospitalization evaluate Forced groups hospital hospitalized patient in both group log rank male males median age moderate Mortality non-randomized objective outcome pathogenic pathophysiology Patient plasma plasma exchange polymerase chain reaction Polymerase chain reaction testing Primary outcome progression PSM reduced Result retrospective secondary Secondary outcomes selected severity significantly standard care Standard of care supportive care survival Symptom syndrome the patient Therapeutic plasma exchange TPE treated Treatment triggered Viral viral clearance was done was used with COVID-19 [DOI] 10.1371/journal.pone.0244853 PMC 바로가기 [Article Type] Research Article
Comparison of antiviral effect for mild-to-moderate COVID-19 cases between lopinavir/ritonavir versus hydroxychloroquine: A nationwide propensity score-matched cohort study로피나비르/리토나비르 대 히드록시클로로퀸 간의 경증 내지 중등도 COVID-19 사례에 대한 항바이러스 효과 비교: 전국적인 성향 점수 일치 코호트 연구Comparative Study Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] age Analysis Antiviral effect benefit case-control study cohort study conducted control group control groups controls COVID-19 COVID-19 case determine HCQ Health Insurance Hydroxychloroquine insurance IQR Lopinavir Lopinavir/ritonavir malignancy median Mild-to-moderate Multivariate analysis National Health Insurance not significantly different old age Patient patients with COVID-19 Pneumonia prolonged viral shedding propensity score matching PSM retrospective risk factor Ritonavir SARS-CoV-2 service standard care statistically significant steroid steroid use three groups treatment groups Viral viral clearance viral shedding [DOI] 10.1016/j.ijid.2020.10.062 PMC 바로가기 [Article Type] Comparative Study
The use of methylprednisolone in COVID-19 patients: A propensity score matched retrospective cohort studyResearch Article Published on 2020-12-312022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] baseline characteristics clinically conducted coronavirus disease COVID-19 COVID-19 patient Critically ill Effects Efficacy and safety evaluate hospital Hospital stay Hospitalized IMPROVE Methylprednisolone Mild Mortality nasopharyngeal swab test outcomes Patient patients patients with COVID-19 positive Primary outcome prognosis of patient propensity score matching PSM receive receiving recruited Result retrospective cohort study SARS-CoV-2 nucleic acid secondary outcome statistically significant difference treated Treatment turn two groups use of corticosteroid was used with COVID-19 [DOI] 10.1371/journal.pone.0244128 PMC 바로가기 [Article Type] Research Article
Management protocol for emergency aneurysm craniotomy clipping in non-major COVID-19 epidemic areas in Beijing, ChinaResearch Published on 2020-12-222022-10-31 Journal: Chinese Neurosurgical Journal [Category] COVID-19, [키워드] 95% CI Admission adverse event Analysis Aneurysm Aneurysmal subarachnoid hemorrhage Beijing China COVID-19 COVID-19 cases COVID-19 epidemic Craniotomy clipping demographic Epidemic epidemic of COVID-19 evaluated false-negative rate Hospitalized incidence individual Intervention management management protocol medical service no statistical difference Non-major epidemic areas nucleic acid Operating room outcome parameter Patient performed postoperative Prognosis prognosis of patient prognostic propensity score matching protocol protocols PSM required Result retrospective scale screened subarachnoid hemorrhage two groups Undetermined Wuhan, China [DOI] 10.1186/s41016-020-00217-x PMC 바로가기 [Article Type] Research
In silico studies evidenced the role of structurally diverse plant secondary metabolites in reducing SARS-CoV-2 pathogenesisIn silico 연구는 SARS-CoV-2 발병기전을 감소시키는 구조적으로 다양한 식물 2차 대사산물의 역할을 입증했습니다.Article Published on 2020-11-252022-08-31 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] active site anthocyanidins anti-SARS-CoV-2 binding Bioavailability Computational biology and bioinformatics COVID-19 Data analysis Drug discovery drug-likeness enzyme Enzymes evidenced flavonoids flavonol glycoside host cell in vitro in vivo Interaction Ligand lower binding energy molecular docking natural Occurrence plant plants platform present protease Protein provide PSM Receptor binding domain recorded reducing Replication researcher Result RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 pathogenesis Secondary Metabolite secondary metabolites selected Serine silico study small molecule Small molecules target proteins transformation transmembrane serine protease unique Viral viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase viral spike viral spike protein [DOI] 10.1038/s41598-020-77602-0 PMC 바로가기 [Article Type] Article
Impact of Wuhan lockdown on the indications of cesarean delivery and newborn weights during the epidemic period of COVID-19Research Article Published on 2020-08-132022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis changes in chi-square test Chinese control group COVID-19 distress fetal Government hospital Impact indication information lockdown management Newborn objective observation Pregnancy pregnant women Prevent propensity score matching PSM rank sum test reducing Result Retrospective study selected significantly significantly more spread of COVID-19 statistically significant the epidemic two group was performed Wuhan [DOI] 10.1371/journal.pone.0237420 PMC 바로가기 [Article Type] Research Article
COVID-19-Related Fear and Health-Related Safety Behavior in Oncological PatientsPsychology Published on 2020-08-052022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] adherent Anxiety Behavior Cancer cancer diagnosis cancer patient change comparable coping COVID-19 COVID-19 pandemic distress elevated explained fear GAD-7 Germany group Health status healthy control healthy controls IMPROVE information Intervention mental health objective oncology participant participated Patient Prevent propensity score matching PSM Psychological R 2 reported Result Safety SARS-CoV-2 significantly Still treated washing hand [DOI] 10.3389/fpsyg.2020.01984 PMC 바로가기 [Article Type] Psychology
Effect of hypertension on outcomes of adult inpatients with COVID-19 in Wuhan, China: a propensity score–matching analysisResearch Published on 2020-07-062022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] 95% CI Analysis applied chronic Comorbidity COVID-19 COVID-19 patient critically ill patients D-dimer D-dimer level death died discharge Effect enrolled hazard ratio Hospitalized hypertension Increased increased mortality increased risk Inpatient Laboratory lymphocyte Mortality N/L neutrophil non-survivor outcome outcomes participant Patient patients with COVID-19 patients’ mortality previous study Propensity score–matching analysis proportion PSM question radiological Result risk severe COVID-19 shown survived survivor with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s12931-020-01435-8 PMC 바로가기 [Article Type] Research