NAD(H)-loaded nanoparticles for efficient sepsis therapy via modulating immune and vascular homeostasis Research Published on 2022-06-062022-10-05 Journal: Nature nanotechnology [Category] 바이오마커, [키워드] addition Apoptosis approach Bacteremia Cell cells cellular death demonstrated help homoeostasis immune immunomodulator Infection Inflammation key factor life-threatening maintain modulating multidrug-resistant multiorgan injury NAD+ NADH organ dysfunction outcome Pathogenesis prevented Pseudomonas aeruginosa pyroptosis reduced responsible Sepsis suppressed the United State therapeutic efficacy therapy translational Transport treat Vascular function vascular homeostasis [DOI] 10.1038/s41565-022-01137-w [Article Type] Research
Inflammasome activation in infected macrophages drives COVID-19 pathology감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다Article Published on 2022-06-012022-09-12 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA [DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1SARS-CoV-2 비구조 단백질 6은 ATP6AP1을 표적으로 하여 NLRP3 의존성 발열을 유발합니다Article Published on 2022-06-012022-09-11 Journal: Cell Death and Differentiation [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] abrogated activated Activation acute respiratory syndrome coronavirus Analysis Asymptomatic COVID-19 ATP6AP1 ATPase autophagic flux binding caspase-1 coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated epithelial cells exhibited impair induce Infection Inflammasome inflammasome activation inflammasomes inflammatory cell Inflammatory cell death inhibit inhibited interleukin L37F live SARS-CoV-2 lung epithelial cell Lung epithelial cells lung tissues lysosome acidification maturation metformin Mutation NLRP3 non-structural protein NSP6 overexpression Patient pharmacological Polydatin proton pump pyroptosis receptor signaling reduced respiratory SARS-CoV-2 serological markers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 suggested Support Transcriptome transcriptome analysis Trigger triggered upstream vacuolar variant viral pathogenicity weakened [DOI] 10.1038/s41418-021-00916-7 PMC 바로가기 [Article Type] Article
Pyroptosis and Its Role in SARS-CoV-2 InfectionPyroptosis와 SARS-CoV-2 감염에서의 역할Review Published on 2022-05-232022-09-12 Journal: Cells [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Caspases cleaved contribute COVID-19 pathology described disease downstream event excessive inflammation gasdermins GSDMD Health humans Inflammasome Inflammatory cell death inhibitor interleukin-1β molecular NLRP3 NLRP3 inflammasome pathway pyroptosis role SARS-CoV-2 [DOI] 10.3390/cells11101717 PMC 바로가기 [Article Type] Review
Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity가용성 P2X7 수용체는 COVID-19 환자의 혈장에서 상승하고 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Activation acute respiratory distress Bacterial Biomarker C-reactive protein concentration cause cell death characterized Concentration COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 severity cytokine danger signal death experimental evidence extracellular ATP hypoxia IL-1 receptor antagonist IL-18 IL-1β IL-6 increase in induce inflammasome activation Inflammation Inflammatory response lung mononuclear cell NLRP3 NLRP3 inflammasome P2X7 Peripheral blood pharmacological target plasma Pneumonia positively correlated pro-inflammatory cytokines purinergic receptors pyroptosis receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual supernatant syndrome triggered triggering viral infections with COVID-19 [DOI] 10.3389/fimmu.2022.894470 PMC 바로가기 [Article Type] Article
Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cellsArticle Published on 2022-05-162023-06-15 Journal: Molecular Cell [Category] COVID19(2023년), MERS, SARS, [키워드] 3CL proteases epithelial cells gasdermins NLRP1 inflammasome pyroptosis SARS-CoV-2 [DOI] 10.1016/j.molcel.2022.04.033 PMC 바로가기 [Article Type] Article
Pyroptosis targeting via mitochondria: An educated guess to innovate COVID-19 therapiesArticle Published on 2022-05-012023-07-06 Journal: British Journal of Pharmacology [Category] COVID19(2023년), [키워드] mitochondria and pharmacology pyroptosis SARS-CoV-2 [DOI] 10.1111/bph.15670 PMC 바로가기
Aspulvins A-H, Aspulvinone Analogues with SARS-CoV-2 M pro Inhibitory and Anti-inflammatory Activities from an Endophytic Cladosporium spAspulvins A-H, SARS-CoV-2 M pro 억제 및 항염증 활성을 갖는 Aspulvinone 유사체 내생성 Cladosporium sp에서Review Published on 2022-04-222022-09-11 Journal: Journal of natural products [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation activity acute respiratory syndrome acute respiratory syndrome coronavirus analogue analogues Analysis anti-inflammatory activity candidate Candidates Casp caused Cladosporium cleavage Compound compounds conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cultures determine IL-1β Infection inflammatory reaction inflammatory reactions inhibit SARS-CoV-2 inhibiting inhibitory activity isolate Lactate lactate dehydrogenase LDH M pro maturation NLRP3 NLRP3 inflammasome occurred protease pyroptosis reduce SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Structure structures Treatment [DOI] 10.1021/acs.jnatprod.1c01003 PMC 바로가기 [Article Type] Review
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation Research Published on 2022-04-062022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 치료기술, 치료법, 치료제, [키워드] abort activate activated Activation acute respiratory distress AIM2 Autopsy blood monocyte caspase-1 cause Cell contribute COVID-19 pathogenesis Culture death endothelial cells epithelial gasdermin D infected cell infected with SARS-CoV-2 Infection Infectious virus Inflammasome inflammasomes Inflammation Inflammatory Inflammatory cell death invasive lung Macrophage monocyte Monocytes NLRP3 patients with COVID-19 plasma promote pyroptosis receptors recipient replicate SARS-CoV-2 SARS-COV-2 infection severe COVID-19 supernatant systemic inflammation tissue-resident macrophages Trigger undergo Vaccine virus [DOI] 10.1038/s41586-022-04702-4 [Article Type] Research
STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도Article Published on 2022-03-252022-09-11 Journal: Cell Death & Disease [Category] SARS, 치료법, [키워드] Activation acute lung inflammation acute respiratory distress AIM2 airway amplification amplifying Apoptosis apoptosis induction ARDS CASP8 caspase-3 cell death cGAS cleavage complex contribute Cytokines cytoplasm DDX41 dinucleotide Disruption DNA DNase I double-stranded dsDNA ENhance epithelial extracellular DNA followed by gasdermin D IFN IFN-I IFNAR1 IL-1β IL-6 immune response immune responses induce Infection inflammasomes Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response interferon IRF3 low dose lung Lung inflammation mice MLKL necroptosis NET NETosis neutrophilic neutrophilic response NF-kB NF-kB pathway NLRP3 NLRP3 inflammasome nucleotide pathway Phosphorylation priming pro-inflammatory cytokine pro-inflammatory cytokines pyroptosis receptor RIPK3 SARS-COV-2 infection severe ARDS signaling pathway silica smoke stimulator STING subsequent suggested syndrome TBK1 therapeutic strategy TLR9 TNFR1 TNFα Treatment triggered Tumor tumors Type I IFN type I IFN response type I interferon upregulation viral infection ZBP1 [DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article