International Nonproprietary Names (INN) for novel vaccine substances: A matter of safety새로운 백신 물질에 대한 INN(International Nonproprietary Names): 안전성 문제Review Published on 2022-01-032022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] applicability assigned Biological Biological Standardization Committee COVID-19 COVID-19 pandemic criteria ENhance exchange expert explain facilitate Health Organization inactivated information ingredient International Nonproprietary Names live-attenuated vaccine live-attenuated vaccines mRNA vaccines name novel Novel vaccine substances novel vaccines nucleic acid nucleic acids patient safety pharmacovigilance recipients Recombinant protein recombinant proteins Safe SARS-CoV-2 SARS-CoV-2 vaccine the WHO Traditional unique Vaccine Vaccines Viral vector vaccines virus variant virus variants WHO World Health Organization [DOI] 10.1016/j.vaccine.2021.11.054 PMC 바로가기 [Article Type] Review
A two-dose optimum for recombinant S1 protein-based COVID-19 vaccination재조합 S1 단백질 기반 COVID-19 백신 접종을 위한 최적의 2회 용량Article Published on 2022-01-012022-09-12 Journal: Virology [Category] SARS, 진단, [키워드] addition adjuvant binding antibody Candidates combating coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine described dose Dose optimum IgG immunization Immunoglobulin MPL Neutralizing antibody response Protein protein vaccine public health emergency re-emerging disease Recombinant protein responses robust Safe Saponin subunit Subunit vaccine suggested the antibody response vaccination Vaccine virus-neutralizing antibody weakened [DOI] 10.1016/j.virol.2021.11.011 PMC 바로가기 [Article Type] Article
SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patientsSARS-CoV-2 재조합 단백질은 COVID-19 회복기 환자의 샘플에서 뚜렷한 세포 및 체액 면역 반응 프로필을 자극합니다Original Article Published on 2021-11-232022-09-10 Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen antigens blood sample Blood samples CD3+ cellular Cellular immune response cellular immune responses cellular immunity chemiluminescence Contact contact with convalescent convalescent individual convalescent individuals coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent patient Determination domain Donor ELISA ELISAs examined groups humoral humoral immune response Humoral response IFN-γ IgG antibodies IgG antibody Immune profile immune response immune responses Immunity individual individuals investigated Lymphocytes membrane nucleocapsid overlapping Patient peptide peptide pool peptide pools peptides pool profile Proteins RBD Receptor-binding domain Recombinant protein recombinant proteins regions respiratory S1/S2 SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 spike sequence serum serum IgG antibodies serum IgG antibody severe acute respiratory syndrome Coronavirus shown stimulate Stimulation T cell T cells T lymphocyte T lymphocytes volunteers [DOI] 10.6061/clinics/2021/e3548 PMC 바로가기 [Article Type] Original Article
Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern불활성화 백신 2회 투여 후 재조합 단백질 소단위 백신 부스터는 항-RBD 반응을 극적으로 향상시키고 SARS-CoV-2 및 우려 변이체에 대한 역가를 중화Letter to the Editor Published on 2021-11-232022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 진단, [키워드] anti-RBD Biological techniques booster concern immunology Inactivated vaccine Neutralizing titer Recombinant protein response SARS-CoV-2 subunit Vaccine [DOI] 10.1038/s41422-021-00590-x PMC 바로가기 [Article Type] Letter to the Editor
Site-Specific Glycosylation Patterns of the SARS-CoV-2 Spike Protein Derived From Recombinant Protein and Viral WA1 and D614G StrainsChemistry Published on 2021-11-192022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 receptor Analysis analyzed Cell cell substrate characterized complex core Critical D614G D614G variant defined domain downstream Eclipse Efficiency glycan glycan shield glycans glycosylated glycosylation glycosylation pattern HEK293 high-mannose Host Host–pathogen interaction hydrophilic in viral Infection Interaction less Local microheterogeneity monomer Mutation N-glycan N-glycosylation N-glycosylation site O-glycosylation Orbitrap pattern predicted produced Protein RBD recent recombinant Recombinant protein reported reveal S1 and S2 S1 domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike Spike protein Spike proteins strain substrate the SARS-CoV-2 Vero Vero cells Vero E6 virus WA1 WA1 strain [DOI] 10.3389/fchem.2021.767448 PMC 바로가기 [Article Type] Chemistry
Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffiiCommunication Published on 2021-11-152022-10-27 Journal: Biotechnology and bioengineering [Category] COVID-19, [키워드] Antigen approach candidate Cell clinical trial COVID‐19 COVID‐19 Elimination genetic engineering Health Host methanol microbial microbial engineering other variant Pichia pastoris platform prevention Protein Protein subunit RBD receptor‐binding domain Recombinant protein removal reported SARS‐CoV‐2 secreted secreted protein Spike protein Stress Subunit vaccine the RBD protein transfer Vaccine vaccine antigen vaccine candidate vaccine candidates Vaccines yeast [DOI] 10.1002/bit.27979 PMC 바로가기 [Article Type] Communication
SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin SystemsSARS-CoV-2는 보체 및 키닌 시스템의 활성화를 통해 COVID-19 병리를 악화시킵니다Immunology Published on 2021-11-052022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] activate Activation acute respiratory syndrome best binding blockade bradykinin C1q classical pathway complement complement system contribute COVID-19 Efficiency ELISA ENCODE generate Genome globular head Human plasma include inflammatory pathway Kallikrein Kallikrein-kinin system Kinin kinin-kallikrein system membrane molecular weight multi-organ failure normal human plasma nucleocapsid peptide peptides platform post COVID “long-haulers” Protein receptor Recombinant protein respiratory SARS-CoV-2 Severe acute respiratory syndrome solid phase SPR structural protein structural proteins surface plasmon resonance System the SARS-CoV-2 therapeutic Treatment treatment of COVID-19 Trigger triggers turn Vasoactive Viral viral particle [DOI] 10.3389/fimmu.2021.767347 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 variants and effectiveness of vaccines: a review of current evidenceSARS-CoV-2 변이체 및 백신의 효과: 현재 증거 검토Review Published on 2021-11-042022-09-11 Journal: Epidemiology and Infection [Category] MERS, SARS, 변종, 진단, [키워드] Adenovirus administration Alpha B.1.617.2 binding circulating variant contagious Delta dominant Effectiveness Epsilon Evidence human ACE2 receptor Immune escape increase morbidity Mortality mRNA Mutagenesis natural infection Neutralizing activity pandemic Protein provoke public health Recombinant protein Reinfection SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus severe acute respiratory syndrome coronavirus 2 significantly spike mutations Transmissibility vaccination Vaccine Vaccines variant variants variants of concern variants of interest variants of SARS-CoV-2 VoC VOCs [DOI] 10.1017/S0950268821002430 PMC 바로가기 [Article Type] Review
Combination of conserved recombinant proteins (NP & 3M2e) formulated with Alum protected BALB/c mice against influenza A/PR8/H1N1 virus challengeArticle Published on 2021-11-012023-06-23 Journal: Biotechnology letters [Category] 신종인플루엔자, [키워드] Influenza virus M2e NP Recombinant protein Universal vaccine [DOI] 10.1007/s10529-021-03174-2
BPIFB4 Circulating Levels and Its Prognostic Relevance in COVID-19BPIFB4 순환 수준 및 COVID-19에서의 예후 관련성THE JOURNAL OF GERONTOLOGY: Biological Sciences Published on 2021-10-162022-09-10 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 바이오마커, 변종, [키워드] aging animal models BPIFB4 CD69 cell lines characterized circulating Comorbidities Comorbidity contrary correlated COVID-19 COVID-19 patient COVID-19 patients cytotoxicity deleterious inflammation demonstrated develop disease severity downregulation early stage early stages enrichment event Evidence Genotype Haplotype healthy healthy control homeostatic homozygous IL-18 IL-1B Immunity function immunomodulatory in vitro individual infected cells Inflammation Inflammatory response inflammatory stimuli involved less Level Longevity lysate lysates MCP-1 minor allele minor alleles Missense mononuclear cell mononuclear cells Mortality open Peripheral blood plasma plasma concentration polymorphism Prognostic value progression of disease Protective Protein rapid increase Recombinant protein reduction Relevance risk of COVID-19 SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells selected senescence shown significantly significantly higher single-nucleotide single-nucleotide polymorphism susceptible T cell T cells target cell TCD4 TCD8 therapeutic therapeutic use variant virus infection [DOI] 10.1093/gerona/glab208 PMC 바로가기 [Article Type] THE JOURNAL OF GERONTOLOGY: Biological Sciences