Common host variation drives malaria parasite fitness in healthy human red cells일반적인 숙주 변이가 건강한 인간 적혈구에서 말라리아 기생충의 적합성을 증가시킨다.Article Published on 2021-09-232024-08-08 Journal: eLife [Category] 말라리아, [키워드] Human malaria natural variation P. falciparum parasite fitness Plasmodium falciparum red blood cells [DOI] 10.7554/eLife.69808 PMC 바로가기
Targeting Host Glycolysis as a Strategy for Antimalarial Development말라리아 치료제 개발을 위한 전략으로서 숙주 해당작용 표적화Original Research Published on 2021-09-162024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antimalarial Enolase erythrocyte Glycolysis malaria oxidative stress Plasmodium red blood cells [DOI] 10.3389/fcimb.2021.730413 PMC 바로가기 [Article Type] Original Research
Multi-Organ Histopathological Changes in a Mouse Hepatitis Virus Model of COVID-19Article Published on 2021-08-272022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] alveolar animal model Asymptomatic Blood blood vessels Brain bronchiolar capillary cause Cell change changes characterized cortical COVID-19 COVID-19 pandemic Cytokine storm death distal edema epithelial hemorrhage Hemorrhagic Hepatitis Human humans hyaline membrane formation infect Infection infiltration inoculated interstitial interstitial tissue intra-alveolar liver macrophages mechanism mice Mild Model moderate mononuclear cell mouse mouse hepatitis virus-1 multiorgan histopathology Necrosis necrotic necrotic debris Neuron nuclei organ system oxidative stress pathophysiologic peribronchiolar perivascular Pneumonia precipitated red blood cells renal reported representing Respiratory illness responsible Safe SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection Septic shock severe lung inflammation severe symptom therapeutic interventions thrombosis thrombotic event Tubular Necrosis uninfected vascular congestion vascular defect vessels virus was used weight loss widespread [DOI] 10.3390/v13091703 PMC 바로가기 [Article Type] Article
Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cellsarticle Published on 2021-05-312024-09-01 Journal: Cellular and Molecular Life Sciences [Category] 말라리아, [키워드] Annexin V host-parasite interactions malaria phosphatidylserine exposure Plasmodium falciparum red blood cells [Article Type] article
A Lab‐On‐chip Tool for Rapid, Quantitative, and Stage‐selective Diagnosis of Malaria말라리아의 신속하고 정량적이며 단계 선택적 진단을 위한 Lab-On-chip 도구Article Published on 2021-05-132024-08-08 Journal: Advanced Science [Category] 말라리아, [키워드] diagnostic tests hemozoin nanocrystals impedimetric detection lab‐on‐chip magnetic sorting malaria red blood cells [DOI] 10.1002/advs.202004101 PMC 바로가기
Application of frozen and stored glutaraldehyde-fixed turkey red blood cells for hemagglutination and hemagglutination inhibition assays for the detection and identification of influenza virusesArticle Published on 2021-03-012023-06-23 Journal: Journal of virological methods [Category] 신종인플루엔자, [키워드] glutaraldehyde hemagglutination Hemagglutination inhibition Influenza red blood cells [DOI] 10.1016/j.jviromet.2020.114046
Morphologic Changes in Circulating Blood Cells of COVID-19 PatientsInfectious Disease Published on 2021-02-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abnormality activated addition age Anemia Appropriate average basophilic Blood Blood cells CBC change changes in chromatin Complete complete blood count coronavirus disease COVID-19 COVID-19 patients cytoplasm described diagnosis of COVID-19 electronic medical records females help hematologic identify lymphopenia majority male management monocyte morphologic changes morphological feature morphology neutrophil neutrophilic Neutrophils nuclear objective pandemic parameter Patient Peripheral blood peripheral blood cell peripheral blood finding peripheral smear Platelet positive Quantitative red blood cell red blood cells Result retrieved Seven the patient White blood cells [DOI] 10.7759/cureus.13416 PMC 바로가기 [Article Type] Infectious Disease
Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients인간 적혈구 전구 세포가 SARS-CoV-2에 직접 감염됨: 중증 COVID-19 환자의 적혈구 생성에 대한 시사점Report Published on 2021-02-052022-09-10 Journal: Stem Cell Reports [Category] MERS, SARS, 치료기술, 치료제, [키워드] ACE2 ACE2 expression Anemia Bone marrow cause CD34 Cell cells circulating circulation clinical symptom Clinical symptoms colonies colony contribute COVID-19 COVID-19 patient COVID19 defined erythroid erythropoiesis expansion hemoglobin highest Human human hematopoietic stem/progenitor cells hypoxia impairing increase in induce infect Infection initial intensive care local inflammation nucleated red cells progenitor progenitor cell red blood cell red blood cells reduced SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patient severe COVID-19 patients Severe patient Spread Stress target cell the patient these cell These cells tissues TMPRSS2 virus [DOI] 10.1016/j.stemcr.2021.02.001 PMC 바로가기 [Article Type] Report
Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling MethodPharmacology Published on 2021-01-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] accumulated analyzed AUC biodistribution Blood Brain Clinical studies collected Concentration conducted Course cynomolgus macaque cynomolgus macaques decrease demonstrated descending described Determining distribution dosing regimen elimination rate constant euthanized evaluate faster fat group HCQ Hydroxychloroquine kidney liver lung lung tissue macaque modeling pharmacokinetic PK parameter plasma Population Population pharmacokinetics protein precipitation Quantitative receive red blood cells Result single dose spleen suggested time-dependent tissue tissues translation treatment regimen Urine Volume was determined [DOI] 10.3389/fphar.2020.602880 PMC 바로가기 [Article Type] Pharmacology
The role of haematological parameters in patients with COVID-19 and influenza virus infectionCOVID-19 및 인플루엔자 바이러스 감염 환자에서 혈액학적 매개변수의 역할Original Paper Published on 2020-11-052022-09-12 Journal: Epidemiology and Infection [Category] SARS, 진단, [키워드] basophils Biomarker can be used coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cut-off value Delta neutrophil index DNI eosinophil eosinophils evaluated Follow-up group haematological parameter Haemoglobin healthy healthy control healthy controls highest Infection Inflammatory Influenza Influenza virus laboratory data leucocytes Lower lymphocyte Lymphocytes neutrophil Neutrophil-to-lymphocyte ratio Neutrophils NLR Novel coronavirus Patient patients with COVID-19 Platelet platelet-to-lymphocyte ratio Platelets predict red blood cell red blood cells SARS-CoV-2 sensitivity Severe patient severe patients severity severity of COVID-19 specificity the disease Treatment Wuhan, China [DOI] 10.1017/S095026882000271X PMC 바로가기 [Article Type] Original Paper