Gender-based violence during COVID-19 among adolescent girls and young women in Nairobi, Kenya: a mixed-methods prospective study over 18 monthsOriginal Research Published on 2022-02-242022-10-28 Journal: BMJ Global Health [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] Adolescent age association child health Cohort condition COVID-19 COVID-19 pandemic Endemic Factor Follow-up form Gender group discussion Impact Intimate partner violence Kenya pandemic persistence Prevalence Prospective Study public health Qualitative Quantitative reflect Result Stress stressors Support trajectory underlying condition women Youth [DOI] 10.1136/bmjgh-2021-007807 PMC 바로가기 [Article Type] Original Research
Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene moduleE484K 탈출 돌연변이를 갖는 SARS-COV-2 변이체로 감염된 COVID-19 환자의 면역 전 사체 분석은 별개의 유전자 모듈을 식별합니다.Article Published on 2022-02-182022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료법, [키워드] ACE2 receptor activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Alpha variant Analysis antibodies Beta binding Cohort Computational biology and bioinformatics conserved convalescence coronavirus Course COVID-19 disease COVID-19 pandemic COVID-19 pathology COVID-19 patient disease disease severity Diseases E484K elicit elicited escape mutation expressed Gamma Gene Expression genomic homozygous hospitalized patient hospitalized patients identify immune immune response immune responses immune signature infected with SARS-CoV-2 investigated Medical research molecular monocyte Monocytes Mutation Neanderthal Neutralizing activity no difference no differences OAS1 offer outcome Patient reduced reflect reported respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Transcriptome transcriptomes Treatment variant Viral viral infection viral infections while [DOI] 10.1038/s41598-022-06752-0 PMC 바로가기 [Article Type] Article
Young people’s experiences of COVID-19 messaging at the start of the UK lockdown: lessons for positive engagement and information sharingResearch Published on 2022-02-182022-10-28 Journal: BMC Public Health [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] adhere Adolescence Analysis conducted COVID-19 COVID-19 epidemic COVID-19 infection Critical develop Edinburgh emotional Government Government messaging group group discussion help information initial involved likelihood lockdown media National pandemic positive Qualitative recommendation reduce reflect Research response Result School social distancing Stage university University College London young people [DOI] 10.1186/s12889-022-12755-3 PMC 바로가기 [Article Type] Research
Association of cardiometabolic microRNAs with COVID-19 severity and mortalityCOVID-19 중증도 및 사망률과 심혈관 대사성 microRNA의 연관성Fast-Track Original Article Published on 2022-02-102022-09-10 Journal: Cardiovascular Research [Category] 바이오마커, [키워드] acute phase acute phase response age association Biomarkers Blood BMI candidate Candidates cardiometabolic Cell cell activation Chain Reaction circulating miRNA circulating miRNAs Cohort combinations coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 severity D-dimer determine differentially expressed endothelial healthy control healthy controls hepatocyte ICU intensive care lead liver longitudinal samples marker microRNA MicroRNAs Mild miR-122 miRNA miRNAs moderate Mortality Multiorgan myeloperoxidase Myocyte neutrophil neutrophil count neutrophil counts neutrophil degranulation outcome parameter patients performed plasma Platelet polymerase chain polymerase chain reaction positive predictor Protein proteomics proteomics data Quantitative reduced reflect reverse transcription reverse transcription quantitative polymerase chain reaction RNA-Seq SARS-CoV-2 selected severity tissue tissue injury Trajectories troponin with COVID-19 [DOI] 10.1093/cvr/cvab338 PMC 바로가기 [Article Type] Fast-Track Original Article
Prevalence of Antibodies to SARS-CoV-2 Following Natural Infection and Vaccination in Irish Hospital Healthcare Workers: Changing Epidemiology as the Pandemic ProgressesMedicine Published on 2022-02-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI adjusted relative risk anti-S anti-spike antibodies antibodies aRR assistant black Breakthrough infection calculated carried changes in Changing Characteristics close contact Contact COVID-19 COVID-19 seroprevalence determinants effort HCW healthcare healthcare worker healthcare worker (HCW) hospital hospital seroprevalence SARS-CoV-2 Host increase in Infection Infection prevention Ireland magnitude measure mitigate multivariable natural occurred pandemic participated Patient percentage positive progression questionnaire reflect regression analysis Result risk risk factor SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 antibody testing SARS-CoV-2 seroprevalence Sequencing serological response serology testing Seroprevalence significantly vaccination WGS whole genome with COVID-19 [DOI] 10.3389/fmed.2021.758118 PMC 바로가기 [Article Type] Medicine
Delta neutrophil index and C-reactive protein: a potential diagnostic marker of multisystem inflammatory syndrome in children (MIS-C) with COVID-19델타 호중구 지수 및 C 반응성 단백질: COVID-19가 있는 어린이(MIS-C)의 다기관 염증 증후군의 잠재적 진단 마커Observational Study Published on 2022-02-012022-09-11 Journal: European journal of pediatrics [Category] MERS, 바이오마커, 임상, [키워드] 113 patient 113 patients Absolute lymphocyte count absolute neutrophil count albumin ALC Analysis ANC C-reactive protein can be used children circulating clinician control group correlation COVID COVID-19 CRP cutoff value Delta Delta neutrophil index determine Diagnosis diagnostic Diagnostic marker DNI elevated evaluate evaluated fraction granulocyte Granulocytes healthy controls Hemogram hyperinflammation immature Infection Inflammation Inflammatory Laboratory life-threatening lymphocyte marker Mild MIS MIS-C moderate multisystem inflammatory syndrome in children Negative predictive value neutrophil observational study Patient Platelet Platelet count platelet counts Positive predictive value Predictive value reflect retrospective sedimentation sensitivity serum severity sodium specificity statistically significant syndrome were recorded with COVID-19 [DOI] 10.1007/s00431-021-04281-y PMC 바로가기 [Article Type] Observational Study
Neurological emergency at the COVID-19 pandemic: report from a referral hospital in Eastern Piedmont, ItalyCovid-19 Published on 2022-01-182022-10-30 Journal: Neurological Sciences [Category] Coronavirus, COVID19(2023년), SARS, [키워드] Acute neurology Admission affected analyzed applied changes in condition contrary COVID COVID-19 decrease Department described Diagnosis Emergency evaluated hospital interval Italy management Mild neurological Neurological diseases NEUROLOGY no difference pandemic Patient Piedmont proportion public health reduction reflect remained reperfusion Result significantly stroke stroke unit therapy Treatment unit variable while [DOI] 10.1007/s10072-022-05895-2 PMC 바로가기 [Article Type] Covid-19
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune ResponseCOVID-19 환자의 혈장에서 회수된 엑소좀은 SARS-CoV-2 스파이크 유래 단편을 노출시키고 적응 면역 반응에 기여합니다Immunology Published on 2022-01-172022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute phase acute respiratory syndrome antigen-presenting cells (APCs) beta-coronavirus caused CD4 chronic inflammation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients Exosome Exosomes Extracellular extracellular vesicle fragment globe immune activation immune response immune system immunomodulatory molecules Infectious disease Patient performed plasma Protein proteome recovered reflect response SARS-CoV-2 soluble mediators in immunity spike-derived peptide Spread T-cell responses the disease vector Vesicle viral infection [DOI] 10.3389/fimmu.2021.785941 PMC 바로가기 [Article Type] Immunology
Heptad stereotypy, S/Q layering, and remote origin of the SARS-CoV-2 fusion coreResearch Article Published on 2022-01-152022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] amino acid substitution Analysis cells coiled-coil 6-helix bundle fusion core COVID-19 Critical Ebola ENhance Evolution Features H-bonding help heptad repeat heptad stereotypy highest HIV Hong Kong hotspot HRs inhibitors Local occur pathogen Pathogenesis reflect regions related viruses respiratory pathogen RSV SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 origin SARS-CoV-2 spike protein serine-rich Spread the SARS-CoV-2 the SARS-CoV-2 virus the spike protein therapeutic virus [DOI] 10.1093/ve/veab097 PMC 바로가기 [Article Type] Research Article
The Impact of COVID-19 on the Delivery of Systemic Anti-Cancer Treatment at Guy’s Cancer CentreArticle Published on 2022-01-062022-10-31 Journal: Cancers [Category] COVID-19, [키워드] anti-cancer treatment can be used Cancer cancer patient cancer treatment Chemotherapy clinician Cohort collected comparable COVID-19 COVID-19 infection COVID-19 pandemic death rate decrease delivery demographics disease expected First wave help Immunotherapy Impact increase in increased risk infections Mortality oncology outcome pandemic Patient patients Prevalence real-world data receiving reduction in reflect SACT SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection Severe COVID-19 Infection significant effect significant increase significantly simple solid tumour subsequent Symptom systemic Systemic anti-cancer treatment Treatment vulnerable patients worsening [DOI] 10.3390/cancers14020266 PMC 바로가기 [Article Type] Article