Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article
A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)SARS-CoV-2(COVID-19)에 감염되어 침습적 기계 환기 없이 병원에 입원한 환자에서 이카티반트의 효능과 안전성을 평가하기 위한 다기관, 공개 라벨, 무작위, 개념 증명 II상 임상 시험: 연구 프로토콜(ICAT-COVID)Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 ACE2 acute respiratory distress acute respiratory distress syndrome Antigen ARDS attacks bradykinin caused Clinical efficacy clinical status clinical trial ClinicalTrials Comorbidity control group COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Cytokine storm death Diagnosis discharge discharged doses effective Effectiveness Efficacy Efficacy and safety eligible Endothelial cell endothelial cells EudraCT Evidence evidence of expected experimental group global pandemic Healthcare system Healthcare systems hospital Hospitalized Icatibant include infected with SARS-CoV-2 Inflammatory response inhibiting invasive mechanical Invasive mechanical ventilation Mortality multicenter Open-label outcome Patient patients hospitalized Pneumonia Primary outcomes protease pulmonary infiltrates Radiographic randomization Randomized receive receptor receptor antagonist respiratory distress Respiratory distress syndrome RT-PCR Safe Sample size SARS SARS-CoV-2 secondary Secondary outcomes Spain Standard of care Study protocol subcutaneously Symptoms syndrome the SARS-CoV-2 the WHO thought treat Treatment viral infection with COVID-19 working hypothesis [DOI] 10.1186/s13063-022-06219-7 PMC 바로가기 [Article Type] Article
A targetable ‘rogue’ neutrophil-subset, [CD11b+DEspR+] immunotype, is associated with severity and mortality in acute respiratory distress syndrome (ARDS) and COVID-19-ARDS표적화 가능한 '불량' 호중구 하위 집합인 [CD11b+DEspR+] 면역형은 급성 호흡 곤란 증후군(ARDS) 및 COVID-19-ARDS의 중증도 및 사망률과 관련이 있습니다Article Published on 2022-04-042022-09-11 Journal: Scientific Reports [Category] 바이오마커, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome antibody Apoptosis ARDS arise assays association blocked Critical death detect dual dysregulated Endothelin Ex vivo expressing humanized identify IgG4 immunotype induce induction of apoptosis inhibitor inhibitors insufficiency internalization kill Ligand lung tissue MOF monocyte Monocytes Mortality NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps neutrophil function Neutrophils pathogenic Pathogens Patient peptide pleiotropic progression receptor respiratory distress Respiratory distress syndrome rhesus scRNA-seq severity syndrome Therapeutic approach tissue injury [DOI] 10.1038/s41598-022-09343-1 PMC 바로가기 [Article Type] Article
Overview of clinical outcome and therapeutic effectiveness of Favipiravir in patients with COVID-19 admitted to intensive care unit, Riyadh, Saudi Arabia사우디아라비아 리야드의 중환자실에 입원한 COVID-19 환자에 대한 Favipiravir의 임상 결과 및 치료 효과 개요Article Published on 2022-04-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 임상, 진단, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome age analyzed antivirals approved ARDS BMI body mass body mass index Chloroquine Clinical outcome collected Comorbidities Comorbidity complications conducted control group Corticosteroid cough COVID-19 COVID-19 patient COVID-19 vaccine Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine Cytokine storm diabetes Diabetes Mellitus effective Effectiveness Efficacy Efficacy and safety enrolled enzyme Favipiravir Fever FIVE FVP group had no heart disease hospital hypertension ICU ICUs IMPROVE inhibit intensive care intensive care unit intensive care units ischemic heart disease Kingdom majority male management medications not effective other treatment other treatments overall mortality P-value pandemic Patient patients with COVID-19 Potential treatment Randomized Research respiratory distress Respiratory distress syndrome retrospective cohort study RNA RNA polymerase Saudi Arabia severe acute respiratory distress syndrome severe symptoms Shortness of breath statistically significant Symptom syndrome the cytokine storm the disease the mean therapeutic therapeutic efficacy therapy Tocilizumab two groups Viral viral infection viral infections viral replication with COVID-19 [DOI] 10.1016/j.jiph.2022.01.013 PMC 바로가기 [Article Type] Article
Inhaled Placental Mesenchymal Stromal Cell Secretome from Two- and Three-Dimensional Cell Cultures Promotes Survival and Regeneration in Acute Lung Injury Model in Mice2차원 및 3차원 세포 배양에서 흡입된 태반 중간엽 간질 세포 Secretome은 마우스의 급성 폐 손상 모델에서 생존 및 재생을 촉진합니다Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adult stem cells ALI model ARDS Cell cell spheroids cell-free therapy content coronavirus COVID-19 COVID-19 pandemic cultivation damaged death effective Effectiveness exhibited Extracellular Extracellular vesicles FIBRIN fibroblast healthcare histological immunomodulating in some Inflammatory Inflammatory diseases inhalation Inhaled investigated lung Lung inflammation Lung injury lung surfactant lung tissue Lungs management Measures mice Model morbidity and mortality Mortality Patient placental potential therapy problem proteomic regeneration regenerative respiratory distress Respiratory distress syndrome restored SARS-CoV-2 Secretome severe acute respiratory syndrome Coronavirus severe pneumonia stromal cell surfactant survival syndrome Taking therapeutic tissue regeneration [DOI] 10.3390/ijms23073417 PMC 바로가기 [Article Type] Article
The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성Article Published on 2022-03-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses [DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article
Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients호중구 세포외 트랩의 혈장 표지자는 COVID-19 관련 ARDS 환자의 생존과 관련이 있지만 폐색전증과는 관련이 없습니다Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Admission Analysis ARDS Biomarker circulating Clinical outcome clinical outcomes collected Comparisons complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression develop Embolism evaluate Extracellular hospital hospitalized COVID-19 patient hospitalized COVID-19 patients Hypothesis immunothrombosis life-threatening lung damage Mann-Whitney test marker microthrombus moderate disease myeloperoxidase NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps non-survivor Non-survivors Occurrence Patient patients patients hospitalized plasma Plasma levels Prevent pulmonary Pulmonary embolism recent respiratory distress Respiratory distress syndrome responsible restriction severe COVID-19 patients severe disease severe patients survival survivor syndrome therapeutic target total DNA TRAP were assessed with COVID-19 worsening [DOI] 10.3389/fimmu.2022.851497 PMC 바로가기 [Article Type] Article
A Case Report for Using Methylprednisolone for Severe ARDS Caused by SARS-CoV-2 Delta Variant in a Pediatric Patient With Lennox-Gastaut SyndromeLennox-Gastaut 증후군이 있는 소아 환자에서 SARS-CoV-2 Delta 변이로 인한 중증 ARDS에 대한 Methylprednisolone 사용에 대한 증례 보고서Case Reports Published on 2022-03-142022-09-11 Journal: Journal of Korean medical science [Category] SARS, 변종, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered ARDS B.1.617.2 caused children Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease-19 Coronavirus disease-19 (COVID-19) COVID-19 Delta End-Expiratory Pressure Expiratory Pressure extubation Fever high fever high-dose methylprednisolone hospital increased risk intractable Lennox-Gastaut Syndrome Methylprednisolone neurologic observation Oxygenation pandemic Pediatric patient Pediatric patients Positive end-expiratory pressure report reported required respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 delta Seizure Seizures severe acute respiratory syndrome Coronavirus severe ARDS Severe case severe cases severe COVID-19 syndrome the SARS-CoV-2 Tidal volume Treatment variant Volume [DOI] 10.3346/jkms.2022.37.e82 PMC 바로가기 [Article Type] Case Reports
How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법Review Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation Acute kidney injury acute respiratory distress acute respiratory distress syndrome AMY-101 Angiogenesis apoptotic cells ARDS Biomarker bradykinin candidate drug candidate drugs cascade cascade system characterized chemokines Coagulation Coagulation system complement Complement inhibitor complement inhibitors Compound COVID-19 Crosstalk cytokine Cytokines damaged demonstrated dysregulation ecallantide eculizumab Evidence favor ground glass opacities heparin High dose high risk Icatibant IL-6 IL-6 levels in some incidence include Influenza influenza-like symptom Influenza-like symptoms inhibitor initiated Innate innate immune system intensive care treatment Kallikrein lanadelumab lead leukocytes life-threatening LMWH Lung injury mechanical ventilation mechanism moderate MOST oxygen oxygen saturation pandemic pathophysiology Patient patients Phase I plasma plasma proteins Platelets Potential predict Prevent Prognostic value pulmonary damage pulmonary inflammation receptor reduced Regulation respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 infected patient severity Support survival syndrome System systemic target the disease therapeutic option therapeutic options Thromboembolism thrombosis thrombotic Thrombotic complications translated Treatment treatment of COVID-19 Trial Usage Vascular ventilator virus [DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review
Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology featuresCOVID-19 치료용 면역조절제: 가능한 작용 기전 및 면역병리학적 특징Review Published on 2022-03-012022-09-11 Journal: Molecular and cellular biochemistry [Category] MERS, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme Anosmia antagonists applied ARDS blood vessel body aches cause clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 case COVID-19 patient COVID-19 patients COVID-19 treatment Critical critical patients cytokine Cytokine storm Cytokines demonstrated described drug drugs dry cough Endothelial cell endothelial cells excessive secretion feature Fever Health Organization immune system immunomodulatory immunopathology immunosuppressive agent Immunosuppressive agents incidence include Infection Inflammatory responses interleukin investigated lead Lungs mAbs mechanical ventilator mechanism mechanism of action medication membrane mitigate modulating monoclonal antibodies monoclonal antibody mortality rates new virus Novel coronavirus overproduction oxygen Oxygen therapy pandemic pathophysiology Patient patients penetrate Physicians pro-inflammatory factors receptor reduce mortality researchers respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway signaling pathways stimulate Support Symptom syndrome the disease therapeutic compound treat triggering virus World Health Organization Wuhan Wuhan, China [DOI] 10.1007/s11010-021-04325-9 PMC 바로가기 [Article Type] Review