A year living with SARS-CoV-2: an epidemiological overview of viral lineage circulation by whole-genome sequencing in Barcelona city (Catalonia, Spain)SARS-CoV-2와 함께하는 1년: 바르셀로나 시(스페인 카탈로니아)에서 전체 게놈 시퀀싱을 통한 바이러스 계통 순환의 역학 개요Coronaviruses Published on 2022-01-042022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] age antigenic B.1.1 B.1.1.7 B.1.177 B.1.351 B.1.617.2 Barcelona Catalonia circulating circulation clinical setting Complete consensus sequence consensus sequences COVID-19 D614G mutation E484K epidemiological events Genetic genetic diversity genetic variability GISAID hospital Illumina immunological L452R Lineage lineages MiSeq Molecular epidemiology Multiple Mutation N-terminal domain P.1 pandemic predominant primary care protocol Randomly Receptor-binding domain respiratory respiratory sample S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 virus selected sequenced Spain T478K the receptor-binding domain the S protein vaccination variants viruses was performed were used WGS while whole-genome sequencing [DOI] 10.1080/22221751.2021.2011617 PMC 바로가기 [Article Type] Coronaviruses
Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses경증 COVID-19 환자의 바이러스 부하 해결은 선천 면역 반응 및 적응 면역 반응 모두와 관련이 있습니다Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] absence acute phase Adaptive immune response all the patients antibodies antibody Asymptomatic characterized circulating collected Comorbidities Comorbidity COVID-19 COVID-19 patient COVID-19 patients Cytokines detectable dysregulation Efficiency elevated Factor had no hospitalized COVID-19 patient Host IgG IL-1β IL-6 IL-7 IL-8 immune response implicated in viral increase in Inflammation Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators innate immune response interferon Kinetics marker mediators mild COVID-19 patient mild infection Mild symptom mild symptoms Most patient Most patients neutralize Neutralizing antibodies neutralizing antibody no increase over Patient PRNT Receptor-binding domain Resolution respiratory respiratory sample Respiratory samples Saliva saliva samples SARS-CoV-2 SARS-CoV-2 viral load Seroconversion serum serum samples severe COVID-19 strain swab samples Symptom T-cell activation the patient the receptor-binding domain These data TNF-α Viral Viral load Viral RNA viral RNA detection virus isolate Virus neutralization [DOI] 10.1016/j.jcv.2021.105060 PMC 바로가기 [Article Type] Article
COVID-19-associated subacute invasive pulmonary aspergillosisCOVID-19 관련 아급성 침습성 폐 아스페르길루스증Article Published on 2022-01-012022-09-12 Journal: Mycoses [Category] 진단, [키워드] age All the patient Aspergillus change collected complication of COVID-19 COVID-19 Culture described diabetes Diabetic differential diagnosis follow-up period form fungal Fungal infection hospital IgG indolent invasive Lung disease lung lesion Patient patients patients died PCR Pneumonia polymerase chain positive predominant respiratory sample serum severe COVID-19 illness steroid subacute invasive pulmonary aspergillosis. Symptom treated while [DOI] 10.1111/myc.13369 PMC 바로가기 [Article Type] Article
The evaluation of the utility of the GENECUBE HQ SARS-CoV-2 for anterior nasal samples and saliva samples with a new rapid examination protocol새로운 빠른 검사 프로토콜을 갖는 전방 비강 샘플 및 타액 샘플에 대한 Genecube HQ SARS-COV-2의 유용성 평가Comparative Study Published on 2021-12-312022-09-24 Journal: PLoS ONE [Category] 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjusted Chain Reaction Concordance Coronavirus-2 demonstrated evaluated molecular Nasal sample nasal samples Nasopharyngeal samples polymerase chain polymerase chain reaction positive preparation Previous studies previous study protocol provided purification real-time reverse transcriptase Real-time reverse transcriptase polymerase chain reaction respiratory respiratory sample Result reverse transcriptase RT-PCR Saliva saliva samples SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the preparation utility was performed [DOI] 10.1371/journal.pone.0262159 PMC 바로가기 [Article Type] Comparative Study
Prolonged viral shedding of SARS-CoV-2 and related factors in symptomatic COVID-19 patients: a prospective studyResearch Published on 2021-12-272022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95% CI Admission antibody antibody production average clinical information collected contribute COVID-19 COVID-19 patient COVID-19 patients declined enrolled Factor female female gender highest hospital Hospital admission identify IgM antibody initial median time multivariate Cox regression nasopharyngeal negativity Older Older age outbreak Patient population level progression Prolonged prolonged viral shedding Prospective Study quantified quantitative PCR remained respiratory sample Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load significant effect significantly significantly higher supplementary material symptom onset symptomatic symptomatic patient transcriptase viral kinetics Viral load viral shedding Wuhan, China [DOI] 10.1186/s12879-021-07002-w PMC 바로가기 [Article Type] Research
The Performance of Two Rapid Antigen Tests During Population-Level Screening for SARS-CoV-2 InfectionMedicine Published on 2021-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95%CI Antigen antigen test assays Asymptomatic Clinical data collected Community conducted COVID-19 demographic diagnose DiaSorin Head-to-head comparison immunoassay individual infected individuals Infection IQR Laboratory less LIAISON males median age MOST Nasopharyngeal swab offer participant PCR performance performed point-of-care population surveillance positive Positive predictive value Prospective Study random Randomly Rapid recruited respiratory sample RT-PCR SARS-CoV-2 SARS-CoV-2 antigen Screening SD Biosensor selected sensitivity specificity Standard Q Surveillance symptomatic patient TaqPath Test threshold transported utility were excluded [DOI] 10.3389/fmed.2021.797109 PMC 바로가기 [Article Type] Medicine
People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burdenCOVID-19에 걸린 위독한 사람들은 사망을 예측하고 SARS-CoV-2 폐 바이러스 부담을 반영하는 말초 면역 프로필을 나타냅니다Article Published on 2021-12-212022-09-12 Journal: Cell Reports Medicine [Category] SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis association Blood contribute COVID-19 COVID-19 outcome Critically ill CXCL10 death gene modules higher risk immune cell state Immune profile immune state Inflammatory Inflammatory cytokines inflammatory monocytes interferon signaling Lower respiratory tract lung machine learning molecular feature monocyte Mortality myeloid cell outcomes peripheral Predictive respiratory sample SARS-CoV-2 severe COVID-19 single-cell Single-cell RNA sequencing single-cell RNA-seq subsequent transcriptional profile type I interferon upregulation viral burden with COVID-19 [DOI] 10.1016/j.xcrm.2021.100476 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in GermanyPublic Health Published on 2021-12-132022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, SARS, [키워드] Adults affected age Analysis attack rates capillary blood Care children clinical symptom collected contribute COVID-19 COVID-19 pandemic COVID-19 symptom Day day care center described epidemiological Germany Health status include index case information measure nose swab parent polymerase chain positive Prospective Protective real-time RT-PCR reported resolved respiratory sample retrospective reverse transcription Saliva SARS-CoV-2 SARS-COV-2 infection secondary infection rate shedding relative Stool Study design subsequent susceptibility Symptom symptom onset Symptoms tested Transmission Transmission dynamics viral clearance viral shedding Virological [DOI] 10.3389/fpubh.2021.773850 PMC 바로가기 [Article Type] Public Health
HSV-1 reactivation is associated with an increased risk of mortality and pneumonia in critically ill COVID-19 patientsObservational Study Published on 2021-12-062022-10-04 Journal: Critical Care [Category] 임상, [키워드] 95% CI association Bacteremia Blood collected data conducted COVID-19 COVID-19 patient Critically ill evaluate herpes simplex virus HSV HSV-1 increased mortality increased risk Infection infections intensive care investigated Mortality mortality risk factors multivariable occurred Patient patients Pneumonia respiratory sample Respiratory samples Result risk severe SARS-CoV-2 supplementary material [DOI] 10.1186/s13054-021-03843-8 PMC 바로가기 [Article Type] Observational Study
Performance and cost-effectiveness of a pooled testing strategy for SARS-CoV-2 using real-time polymerase chain reaction in Uganda우간다에서 실시간 중합효소 연쇄반응을 이용한 SARS-CoV-2 통합 테스트 전략의 성능 및 비용 효율성Article Published on 2021-12-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 approach Chain Reaction collected Coronavirus-2 COVID-19 Ct values cycle threshold diagnose diagnostic gold gold standard individual interquartile range LMIC median performance polymerase chain polymerase chain reaction pool pooled testing positive real-time polymerase chain reaction reduced remained respiratory sample RT-PCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus tested Uganda [DOI] 10.1016/j.ijid.2021.10.038 PMC 바로가기 [Article Type] Article