Safety, mucosal and systemic immunopotency of an aerosolized adenovirus-vectored vaccine against SARS-CoV-2 in rhesus macaques붉은털 원숭이의 SARS-CoV-2에 대한 에어로졸화된 아데노바이러스 벡터 백신의 안전성, 점막 및 전신 면역 효능Coronaviruses Published on 2022-01-292022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Ad5-nCoV Adenovirus Adenovirus-vectored vaccine aerosol Clinical pathology COVID-19 effective elicited examined immune responses Immunity immunogenicity immunoglobulin A indicated Infection inhalation initial mucosal mucosal immune mucosal immunity nCoV NHP Non-invasive organ organs pathology provide Replication respiratory Respiratory system responses against rhesus macaque rhesus macaques Safe Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine Spike protein subsequent Toxicity transmission of SARS-CoV-2 Vaccination strategy variants vectored vaccine [DOI] 10.1080/22221751.2022.2030199 PMC 바로가기 [Article Type] Coronaviruses
Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaquesCOVID-19 관련 폐 및 간 손상의 단백질체 및 포스포단백질체 프로파일링: 붉은털 원숭이를 기반으로 한 보고서Letter Published on 2022-01-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 진단, [키워드] bioinformatics Experimental organisms Infection Infectious diseases liver lung rhesus macaque [DOI] 10.1038/s41392-022-00882-7 PMC 바로가기 [Article Type] Letter
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs새로운 STING 효능제가 첨가된 범-사베코바이러스 백신은 마우스, 토끼 및 NHP에서 강력하고 내구성 있는 중화 항체 및 T 세포 반응을 이끌어냅니다.Article Published on 2022-01-192022-09-11 Journal: Cell Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] alum Cellular immune response CoVs Diseases elicit elicited exhibited Final hACE2 highlight highly pathogenic humoral immune responses immunization immunized immunology initial Innate immunity lower airway macaque mice Molecular biology NAb NAbs neutralizing antibody NHP NHPs nine outbreak produced RBD-Fc reduced responses against rhesus macaque rhesus macaques sarbecovirus SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARSr-CoVs significantly single dose STING T cell T cell response T cell responses upper and lower airways Vaccine Vaccines variant Viral Viral load [DOI] 10.1038/s41422-022-00612-2 PMC 바로가기 [Article Type] Article
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2 감염 중 면역 역학의 연령 관련 차이Research Article Published on 2022-01-172022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] advanced age age aging Analysis animal animals Antiviral Bronchoalveolar lavage fluid Cellular immune response cellular immune responses clinical observations Clinical signs cohorts cytokine cytokine level cytokine levels difference disease eight evaluated exhibited flow cytometry immune Immune homeostasis immune response immune responses immunohistochemistry impair Increased inflammation-associated gene inflammation-associated genes Inflammatory Innate immune defense innate immune defenses inoculated lipid mediator Local macaque mediator multiplex Older outcomes pro-inflammatory response pulmonary infiltrates responses return rhesus rhesus macaque rhesus macaques risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 single-cell Single-cell transcriptomics sustained T-cell Response T-cell responses Thoracic transcriptomics various tissues Viral viral RNA quantification virus replication [DOI] 10.26508/lsa.202101314 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaquesSARS-CoV-2 백신은 유아 붉은털 원숭이에서 지속적인 면역 반응을 이끌어냅니다.Article Published on 2022-01-132022-09-12 Journal: Science Immunology [Category] MERS, SARS, 진단, [키워드] ACE2 Adults adverse effects antibody binding blocking activity cellular response Cellular responses COVID-19 decrease domain eight elicit elicited group Health IFN-γ IgG IL-17 immune function immune response immune responses Immunity immunized immunogenic immunogenicity Impact Inclusion Infant Infants intramuscularly limit Lipid nanoparticle Lipid nanoparticles magnitude memory B cell memory B cells mitigate Moderna mRNA-1273 vaccine mRNA neutralizing antibody titers novel vaccines peaking pediatric prefusion Prevent proof proof of concept Protein purified RBD rhesus macaque S protein S-2P S1 and S2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe complication severe complications squalene T cell T cell response the SARS-CoV-2 TLR7 TLR7/8 TNF-α Transmission transmission of SARS-CoV-2 two groups Vaccine [DOI] 10.1126/sciimmunol.abj3684 PMC 바로가기 [Article Type] Article
Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates비인간 영장류에서 COVID-19에 대한 재조합 식물 유래 바이러스 유사 입자 백신 후보의 비보조제 및 애주번트 제형이 제공하는 안전성, 면역원성 및 보호Article Published on 2022-01-052022-09-12 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), MERS, SARS, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome adjuvant adjuvants administration animal Antiviral AS03 BALF booster Bronchoalveolar lavage fluid CD4 T cells Cell-mediated immune responses chemotactic factor clinical trials coronavirus coronavirus disease COVID-19 CoVLP CoVLP vaccine CpG CpG1018 demonstrated dose effective vaccine Efficacy Evidence expression humoral IL-4 Immune cell immunization immunized Infection Influenza Intramuscular injection intranasal Lower lung nasal swab Non-humane primates ocular pandemic pathologic plaque-forming unit priming Proinflammatory cytokine Protein vaccines provided reduced responses rhesus macaque Safety SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-infected cell selected significantly single dose stimulated System vaccine candidate Vaccine development vaccine-associated enhanced disease viral replication virus-like particle vaccine virus-like particles VLP [DOI] 10.1038/s41423-021-00809-2 PMC 바로가기 [Article Type] Article
A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primatesResearch article Published on 2022-01-012022-10-05 Journal: Vaccine [Category] 비임상, [키워드] alleles Antigen approach BALB/c binding CD4+ CD4+ T cell CD8+ T cell cellular immunity conserved costly Coverage COVID-19 described Diseases DNA vaccine Electroporation elicit elicited ENCODE epitope Epitope-based vaccine Epitopes Evidence facilitate generate HIV HIV vaccine HLA class II HLA-DR immune response immunization immunized immunodominant immunogen in vivo Increasing induce less MHC mice multiple epitopes Multiple HLA-binding epitopes neutralizing antibody over patients peptides platform Populational vaccine response Result rhesus macaque rhesus macaques shown T cell T cell epitope T cell response transgenic Vaccine Vaccines viral disease viral infections [DOI] 10.1016/j.vaccine.2021.11.076 [Article Type] Research article
Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus MacaquesImmunology Published on 2021-12-242022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] anatomical anatomical compartment anti-spike monoclonal antibody antibodies antibody probes COVID-19 CR3022 demonstrated development fluorescent Frequency identify in vivo infected cell lung macaque macaques nonhuman primates Novel coronavirus pathology Pneumonia probe question Replication respiratory symptom rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection spatiotemporal tissue block track viral spread virus [DOI] 10.3389/fimmu.2021.810047 PMC 바로가기 [Article Type] Immunology
Preclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2Article Published on 2021-12-202022-10-04 Journal: NPJ Vaccines [Category] 비임상, [키워드] acute respiratory syndrome administration Applying binding cellular response clinical trial comparable coronavirus demonstrated DNA plasmid DNA vaccine DNA vaccines dominant IgG immune responses immunogenic Intradermal intramuscular intranasal lung Lung infection mice neutralizing antibody New Plasmid platform Preclinical protective effect rhesus macaque rhesus macaques robust Safe SARS-CoV-2 Spike protein tested Th1 the SARS-CoV-2 the vaccine Vaccine vaccine platform viral pathogens viral replication [DOI] 10.1038/s41541-021-00419-z PMC 바로가기 [Article Type] Article
Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patientsAzvudine은 COVID-19 환자 치료에 효과적인 흉선 유도 항 SARS-CoV-2 약물입니다.Article Published on 2021-12-062022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 치료법, 치료제, [키워드] (RdRp) active form agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Azvudine cells chest X-ray clinical trial compassionate use coronavirus COVID-19 COVID-19 patients cured Dizziness Drug development effective followed by Ground-glass opacities ground-glass opacity HCoV HCoV-OC43 HIV-1 hospital discharge rate Immunity Infectious diseases Inflammation inhibit inhibited lymphocyte mononuclear cell mononuclear cells monophosphate nausea Negative conversion nucleoside oral administration organ damage patients PBMC Peripheral blood Peripheral blood mononuclear cells phase profiles promoted promotion Randomized RATs RdRP reduced rhesus macaque rhesus macaques Ribonucleic acid RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selective Sequencing Side-effect single-arm suggested thymus treating treating COVID-19 patient Trial triphosphate Viral Viral load viral ribonucleic acid virus viruses [DOI] 10.1038/s41392-021-00835-6 PMC 바로가기 [Article Type] Article