cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophagesResearch Article Published on 2021-08-042023-08-30 Journal: Gut Microbes [Category] E형 간염, [키워드] cGAS ISGs murine norovirus RIG-I STING [DOI] 10.1080/19490976.2021.1959839 PMC 바로가기 [Article Type] Research Article
FIP200 restricts RNA virus infection by facilitating RIG-I activationArticle Published on 2021-07-292022-10-31 Journal: Communications Biology [Category] Coronavirus, [키워드] Activation cascade caspase deficiency demonstrated domain expression facilitate facilitated Helicase host susceptibility induce Infection innate immune innate immune response interact Interaction knockout mice mechanism oligomerization pathway Protein recruitment reduced regulate Regulatory restrict RIG-I RIG-I-like receptors RNA RNA virus Signaling signaling molecule susceptible type I interferon Viral RNA Virus-host interactions [DOI] 10.1038/s42003-021-02450-1 PMC 바로가기 [Article Type] Article
SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate ImmunitySARS-COV-2 N 단백질은 타고난 면역을 억제하기 위해 TRIM25- 매개 RIG-I 활성화를 표적으로합니다.Article Published on 2021-07-232022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료법, [키워드] accessory proteins Activation Affect affecting antagonistic characterized clinical picture contributing to counteract COVID-19 Cytokines decrease demonstrated domain ENCODE exacerbated expressed feature host immune system IFN Infection Innate innate immune response Innate immunity Interaction involved Mask mechanism molecular mechanism molecular mechanisms N protein novel SARS-CoV-2 virus occurred Pathways Pattern recognition pattern recognition receptor pro-inflammatory cytokine pro-inflammatory cytokines Protein PRR Recognition reported RIG-I RIG-I activation SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 virus secretion signaling pathways suppresse target the N protein the SARS-CoV-2 TRIM25 Viral viral pathogenesis [DOI] 10.3390/v13081439 PMC 바로가기 [Article Type] Article
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced [DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology
A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-IImmunology Published on 2021-06-162022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute diarrhea acute respiratory syndrome Analysis binding activity caused claimed Comparative conducted coronavirus CoV CoV infection COVID-19 pandemic CoVs Degradation Delay epidemic diarrhea Host IBV IFN IFN response IFN-β independent Inducing infected cell Infectious Bronchitis Virus inhibiting Interaction interferon MERS-CoV Middle East nucleocapsid nucleocapsid protein offer Porcine deltacoronavirus Production Protein retinoic acid-inducible gene I (RIG-I) RIG-I RNA SARS-CoV SARS-CoV-2 Severity of disease subsequent suppress swine acute diarrhea syndrome coronavirus (SADS-CoV) syndrome the N protein therapy ubiquitination Viral protein viruses [DOI] 10.3389/fimmu.2021.688758 PMC 바로가기 [Article Type] Immunology
Type-I interferon signatures in SARS-CoV-2 infected Huh7 cellsArticle Published on 2021-05-182022-10-04 Journal: Cell Death Discovery [Category] 치료제, [키워드] acute respiratory syndrome Antiviral Antiviral strategies approach cause caused Cell Biology cellular coronavirus Coronavirus disease 2019 COVID-19 dysregulated health emergency Huh7 cell HUH7 cells IFIT1 IFN-I IFN-I response IFN-I signaling IFN-β immunology induce inhibit inhibited innate immune response interferon interferon response interferon-stimulated gene investigation MERS-CoV Microbiology observation pathogenesis of SARS-CoV-2 Perspective Protein proteomic recent finding reduce Regulation Regulatory RIG-I SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis senescent susceptibility susceptible therapeutic strategy These cells Treatment viral infection virus [DOI] 10.1038/s41420-021-00487-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1Immunology Published on 2021-05-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome causative pathogen caused complex Coronavirus-2 COVID-19 pandemic Degradation form Host IFN-I IFNβ Immunosuppression induce inhibit interferon-stimulated gene IRF3 M protein MDA5 mechanism membrane protein negative regulation pathogenicity Phosphorylation Production Protein reduced reported RIG-I SARS-CoV-2 suppress suppress the expression TBK1 the disease TRAF3 Type type I interferon ubiquitination [DOI] 10.3389/fimmu.2021.662989 PMC 바로가기 [Article Type] Immunology
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells Research Published on 2021-05-112022-10-05 Journal: Nature Immunology [Category] SARS, 바이오마커, [키워드] 3′ untranslated region abrogate Activation acute respiratory syndrome anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity ATPase C-terminal domain caused chronic obstructive coronavirus Coronavirus disease 2019 cytokine Defense domains early phase efficient expressed Genetic global pandemic Helicase human lung cell human lung cells immune response Interaction interferon lack lung cell mechanism mitochondrial nucleic acid Pathways Patient protein expression pulmonary disease recognize Replication restored RIG-I RNA genome RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication stimulate the SARS-CoV-2 Treatment Trigger upregulation viral genome viral infection viral particle viral spike protein virus [DOI] 10.1038/s41590-021-00942-0 [Article Type] Research
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infectionMETTL3은 SARS-CoV-2 감염 동안 바이러스 m6A RNA 변형 및 숙주 세포 선천성 면역 반응을 조절합니다Article Published on 2021-05-112022-09-11 Journal: Cell Reports [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenosine binding clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 treatment decrease disease downstream ENhance expression Gene Expression Host host cell host genes Host immune response host innate immunity increase Inflammation Inflammatory inflammatory gene inflammatory genes innate immune innate immune response Innate immunity m(6)A RNA modification. methyltransferase METTL3 Modification molecular mechanism Patient physiological reduced reduction in regulate RIG-I RNA RNA modification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe coronavirus disease signaling pathway the SARS-CoV-2 the SARS-CoV-2 virus Treatment viral genome Viral RNA widespread [DOI] 10.1016/j.celrep.2021.109091 PMC 바로가기 [Article Type] Article
SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3Research Paper Published on 2021-04-102022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, MERS, SARS, [키워드] 3C-like protease acute respiratory syndrome antiviral agent cells circulating coronavirus cytoplasm downstream expression highly pathogenic human coronaviruses IFN IFN antagonists IFN-β implication Infection IRF3 MAVS mechanism nsp5 nuclear translocation outcome phosphorylated Phosphorylation protease Protein reported retained RIG-I SARS-CoV SARS-CoV-2 SARS-CoV-2 main protease strain suggested suppresse suppression TBK1 Transcription type I interferon type I interferons variant [DOI] 10.7150/ijbs.59943 PMC 바로가기 [Article Type] Research Paper