Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic ReviewCOVID-19에 대한 항체 기반 치료제의 면역 탈출 변이체 분석: 체계적인 검토Review Published on 2021-12-212022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] accelerated Amino acid CCP convalescent plasma COVID-19 Deletion E484K escape fitness Frequency genomic Immune escape immune evasion implication monoclonal antibodies monoclonal antibody Mutation N-terminal domain Neutralizing neutralizing antibody non-responder plasma public health Receptor-binding domain residue residues responders review SARS-CoV-2 SARS-CoV-2 evolution selective Spike protein the receptor-binding domain the spike protein Therapeutics Treatment variants viral clearance while [DOI] 10.3390/ijms23010029 PMC 바로가기 [Article Type] Review
Striking lineage diversity of severe acute respiratory syndrome coronavirus 2 from non-human sourcesResearch Paper Published on 2021-12-162022-10-28 Journal: One Health [Category] COVID-19, [키워드] acute respiratory syndrome Alpha variant Analysis animals bat Characteristics Cluster Clusters containment strategies coronavirus Delta Environment Felis FIVE Genetic Genome genomic highest hosts humans infecting investigated Lineage lineages majority Neovison Odocoileus pangolin pathogen Phylogenetic tree SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome sequences Spread strain Surveillance the SARS-CoV-2 transmission route variants of concern viral genome virus [DOI] 10.1016/j.onehlt.2021.100363 PMC 바로가기 [Article Type] Research Paper
Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America유럽과 미국에서 백신 내성 돌연변이를 드러내는 SARS-CoV-2 진화 메커니즘Article Published on 2021-12-162022-09-11 Journal: The journal of physical chemistry letters [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] America antibody binding domain can not complementary disrupt domain drugs Europe favor Frequency mechanism Mutation mutations N501Y natural selection neutralize occurred Occurrence omicron pathway Protein recent reduced SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes trajectory Transmission vaccination rate vaccination rates Vaccine Viral viral evolution viral infectivity virus [DOI] 10.1021/acs.jpclett.1c03380 PMC 바로가기 [Article Type] Article
Role of Q675H Mutation in Improving SARS-CoV-2 Spike Interaction with the Furin Binding PocketArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Analysis arginine residue binding pocket circulating clades conformations ENhance Evolution evolutionary relationship expressed furin furin cleavage furin cleavage site greater highlight human host Improving Interaction investigated involved Italy Lineage molecular molecular dynamics mutant Mutation new SARS-CoV-2 performed Phylogenesis Phylogenetic pocket polar predicted Prevalence proteolytic Q675H spike mutation role SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage shown spike spike mutation Spike protein viral entry viral fitness Viral protein VoC VOCs [DOI] 10.3390/v13122511 PMC 바로가기 [Article Type] Article
Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2Research Article Published on 2021-11-162022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adaptive mutations Amino acid antibody escape Antibody neutralization characterization characterized clade Cluster conformation coronavirus decrease deletions early stage European Genetic Genotype homoplasy HR2 in vitro information investigated lack Mutation Nasopharyngeal swab neutralization pandemic postfusion predict reduce reduced rigidity SARS-CoV-2 SARS-CoV-2 evolution sequence sera significantly higher Single nucleotide polymorphism spike spike mutation the S protein the spike protein thermal stability transmission cluster vaccinated individual variant variants viral fitness Viral RNA [DOI] 10.1128/mBio.02315-21 PMC 바로가기 [Article Type] Research Article
Exposing structural variations in SARS-CoV-2 evolutionSARS-CoV-2 진화의 구조적 변이 노출Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution [DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article
Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaptionSARS-CoV-2 스파이크 단백질의 돌연변이 Y453F는 숙주 적응을 위해 밍크 ACE2 수용체와의 상호 작용을 향상시킵니다Research Article Published on 2021-11-082022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, [키워드] ACE2 ACE2 receptor Active surveillance adaptive addition Amino acid amino acid change Analysis binding circulation Cluster convalescent sera convalescent serum COVID-19 patient COVID-19 patients demonstrated develop domain employee ENhance Evolution exhibited functional Genetic variant Host human ACE2 human ACE2 receptor humans identify infected with SARS-CoV-2 initial Interaction less MONITOR Mutation Netherland Netherlands ortholog outbreak Outbreaks position Prevent RBD domain receptor reservoirs risk SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 RBD sequence similarity Spike protein steric Structural analysis suggested susceptible susceptible hosts the RBD the spike protein therapeutic strategy Transmission transmitted Vaccine development Viral viral RBD virus widespread Y453F zoonotic [DOI] 10.1371/journal.ppat.1010053 PMC 바로가기 [Article Type] Research Article
Understanding the Secret of SARS-CoV-2 Variants of Concern/Interest and Immune EscapeSARS-CoV-2 변종 우려/관심 및 면역 탈출의 비밀 이해Immunology Published on 2021-11-052022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 antibody B.1.1.7 B.1.351 B.1.617.2 B.1.621 caused Characteristics convalescent sera coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 epidemic Effect Epidemic escape evaluated global pandemic global public health Immune escape Mortality Mutation Neutralizing neutralizing antibody P.1 pathogenic reported Research respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus stages therapy Transmission understanding Vaccination strategy Vaccine variants variants of concern variants of interest virus infectivity [DOI] 10.3389/fimmu.2021.744242 PMC 바로가기 [Article Type] Immunology
Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccinationSARS-CoV-2 mRNA 백신 접종 후 항체 의존성 강화에 대한 조기 통찰력Article Published on 2021-11-022022-09-11 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 변종, 진단, 치료법, [키워드] antibodies antibody antibody response against Antibody-dependent enhancement approach B-cell CD8 COVID-19 current induce infection rates memory mRNA vaccination neutralization Neutralizing antibodies novel vaccines nucleocapsid protein ORF1 ORF1ab reduced risk SARS-CoV-2 SARS-CoV-2 evolution Spike protein spike protein of SARS-CoV-2 Spike proteins T-cell immunity the spike protein Vaccine Vaccines variant [DOI] 10.1080/21645515.2021.1969855 PMC 바로가기 [Article Type] Article
SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection동물에서의 SARS-CoV-2 진화는 신속한 변이체 선택을 위한 메커니즘을 제안합니다423 Published on 2021-10-292022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] accelerate accumulating amplified animal Animal host animal hosts animal model animals arising cats Cell culture change changes in companion animals Contact contact with COVID-19 patients Cross-species transmission deer dominant variant Evolution ferret ferrets fixation Frequency functional Genes Genome hamster hamsters highlight Host host adaptation hosts Households Human human-to-animal transmission humans in vitro in vivo Infection inoculation Lineage Live virus mammalian mechanism mink molecular nonsynonymous nucleocapsid observation ORF8 patients phenotype plasticity Reinfection repeated residue residues reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variant SARS-CoV-2 variants sequence sequenced Significance species spillover stock Substitution substitutions switching Transmission USA-WA1/2020 variant Vero Vero Cell Viral viral evolution viral lineages viral variant Viral variants virus viruses widespread wild animal wild animals wild-type with COVID-19 [DOI] 10.1073/pnas.2105253118 PMC 바로가기 [Article Type] 423